scholarly journals Constitutive androstane receptor mediates PCB-induced disruption of retinoid homeostasis

2019 ◽  
Vol 381 ◽  
pp. 114731 ◽  
Author(s):  
Igor O. Shmarakov ◽  
Yun Jee Lee ◽  
Hongfeng Jiang ◽  
William S. Blaner
Keyword(s):  
Constitutive Androstane Receptor ◽  
Retinoid Homeostasis

Phenobarbital inhibits calpain activity and expression in mouse hepatoma cells

2016 ◽  
Vol 397 (1) ◽  
pp. 91-96 ◽  
Author(s):  
Nicola Groll ◽  
Ferdinand Kollotzek ◽  
Jens Goepfert ◽  
Thomas O. Joos ◽  
Michael Schwarz ◽  
...  
Keyword(s):  
Cell Proliferation ◽  
Transcriptional Regulation ◽  
Antiepileptic Drug ◽  
Signaling Pathway ◽  
Constitutive Androstane Receptor ◽  
Hepatoma Cells ◽  
Liver Cells ◽  
Mrna Levels ◽  
Calpain Activity ◽  
Mouse Hepatoma

Abstract The antiepileptic drug phenobarbital (PB) exerts hepatic effects related to cell proliferation and tumorigenesis which are closely linked to the Wnt/β-catenin signaling pathway. This pathway is, amongst others, regulated by calpain proteases. We now identified PB as an inhibitor of Wnt/β-catenin signaling in mouse hepatoma cells. Further analyses revealed that PB inhibits calpain activity, an effect which is at least in parts mediated by a transcriptional regulation of calpain mRNA levels and which is furthermore independent of the constitutive androstane receptor, the known mediator of most effects of PB in liver cells.

Regulatory Cross-Talk between Drug Metabolism and Lipid Homeostasis: Constitutive Androstane Receptor and Pregnane X Receptor Increase Insig-1 Expression

2008 ◽  
Vol 73 (4) ◽  
pp. 1282-1289 ◽  
Author(s):  
Adrian Roth ◽  
Renate Looser ◽  
Michel Kaufmann ◽  
Sharon M. Blättler ◽  
Franck Rencurel ◽  
...  
Keyword(s):  
Drug Metabolism ◽  
Cross Talk ◽  
Constitutive Androstane Receptor ◽  
Pregnane X Receptor ◽  
Lipid Homeostasis

scholarly journals Impact of LCA-Associated E14L LRAT Mutation on Protein Stability and Retinoid Homeostasis

Biochemistry ◽  
2017 ◽  
Vol 56 (34) ◽  
pp. 4489-4499 ◽  
Author(s):  
Sylwia Chelstowska ◽  
Made Airanthi K. Widjaja-Adhi ◽  
Josie A. Silvaroli ◽  
Marcin Golczak
Keyword(s):  
Protein Stability ◽  
Retinoid Homeostasis

scholarly journals Constitutive androstane receptor and pregnane X receptor cooperatively ameliorate DSS-induced colitis

2019 ◽  
Vol 51 (2) ◽  
pp. 226-235 ◽  
Author(s):  
Daisuke Uehara ◽  
Hiroki Tojima ◽  
Satoru Kakizaki ◽  
Yuichi Yamazaki ◽  
Norio Horiguchi ◽  
...  
Keyword(s):  
Constitutive Androstane Receptor ◽  
Pregnane X Receptor

scholarly journals MicroRNA-122 Down-Regulation Is Involved in Phenobarbital-Mediated Activation of the Constitutive Androstane Receptor

PLoS ONE ◽  
2012 ◽  
Vol 7 (7) ◽  
pp. e41291 ◽  
Author(s):  
Ryota Shizu ◽  
Sawako Shindo ◽  
Takemi Yoshida ◽  
Satoshi Numazawa
Keyword(s):  
Constitutive Androstane Receptor ◽  
Down Regulation
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