A novel pyrimidine based deep-red fluorogenic probe for detecting hydrogen peroxide in Parkinson's disease models

Parkinson’s disease (PD) is closely related to the oxidative stress induced by excess hydrogen peroxide (H2O2) in organisms. Developing an efficient method for noninvasive and real-time H2O2 detection is beneficial to investigate the role played by H2O2 in PD. In this work, a novel fluorogenic probe (CBH) for living organisms H2O2 detection has been designed, synthesized and characterized. The emission of CBH in PBS solution is very weak. However, when H2O2 was added, the fluorescence of CBH solution was sharply increased for 12-fold, accompanied by the emission peak blue-shifted from 600 to 530 nm. Moreover, the response of CBH to H2O2 is highly sensitive and selective and is not affected by various ROS/RNS, anions, cations, and amino acids. Based on the good performance of CBH for H2O2 detection, it has been successfully applied to visualizing the H2O2 concentration in living cells, Zebrafish and [Formula: see text]. elegans PD models.

Download Full-text

One-pot synthesis of a hydrogen peroxide-selective fluorogenic probe and its application in Parkinson's disease in vitro and vivo models

Materials Advances ◽

10.1039/d0ma00318b ◽

2020 ◽

Vol 1 (5) ◽

pp. 1448-1454 ◽

Cited By ~ 1

Author(s):

Yao Lu ◽

Bo Peng ◽

Xinghan Qiu ◽

Xin Li ◽

Zheng Li ◽

...

Keyword(s):

Parkinson’S Disease ◽

Hydrogen Peroxide ◽

Parkinson's Disease ◽

Multicomponent Reaction ◽

Living Cells ◽

Phosphate Ester ◽

One Pot ◽

Fluorogenic Probe ◽

Abnormal Level

An abnormal level of hydrogen peroxide in neurons is strongly implicated in the progression of Parkinson’s disease. A one-pot multicomponent reaction has been utilized to synthesise phosphate ester-based probe for imaging of H2O2 in living cells and Drosophila PD model.

Download Full-text

A mitochondria-targeted two-photon fluorogenic probe for the dual-imaging of viscosity and H2O2 levels in Parkinson's disease models

Journal of Materials Chemistry B ◽

10.1039/c9tb00576e ◽

2019 ◽

Vol 7 (27) ◽

pp. 4243-4251 ◽

Cited By ~ 15

Author(s):

Hao Li ◽

Chenqi Xin ◽

Gaobin Zhang ◽

Xisi Han ◽

Wenjing Qin ◽

...

Keyword(s):

Parkinson’S Disease ◽

Parkinson's Disease ◽

Disease Models ◽

Two Photon ◽

Fluorogenic Probe ◽

Dual Imaging

Novel two-photon fluorogenic probe could simultaneously monitor changes in the mitochondrial viscosity and H2O2 levels using two different channels.

Download Full-text

Deep-red fluorogenic probe for rapid detection of nitric oxide in Parkinson’s disease models

Sensors and Actuators B Chemical ◽

10.1016/j.snb.2018.12.071 ◽

2019 ◽

Vol 283 ◽

pp. 769-775 ◽

Cited By ~ 7

Author(s):

Mingrui Weng ◽

Xue Yang ◽

Yun Ni ◽

Chenchen Xu ◽

Hang Zhang ◽

...

Keyword(s):

Nitric Oxide ◽

Parkinson’S Disease ◽

Parkinson's Disease ◽

Rapid Detection ◽

Disease Models ◽

Fluorogenic Probe

Download Full-text

A fluorogenic probe based on chelation–hydrolysis-enhancement mechanism for visualizing Zn2+ in Parkinson's disease models

Journal of Materials Chemistry B ◽

10.1039/c8tb03343a ◽

2019 ◽

Vol 7 (14) ◽

pp. 2252-2260 ◽

Cited By ~ 10

Author(s):

Gaobin Zhang ◽

Yanfei Zhao ◽

Bo Peng ◽

Zheng Li ◽

Chenchen Xu ◽

...

Keyword(s):

Parkinson’S Disease ◽

Parkinson's Disease ◽

Real Time ◽

Biological Systems ◽

Disease Models ◽

Enhancement Mechanism ◽

Fluorogenic Probe ◽

Real Time Detection ◽

Role Of Zn

Developing efficient methods for real-time detection of Zn2+ level in biological systems is highly relevant to improve our understanding of the role of Zn2+ in the progression of Parkinson's disease (PD).

Download Full-text