scholarly journals Volatile organic compounds (VOCs) for the non-invasive detection of pancreatic cancer from urine

Talanta ◽  
2021 ◽  
Vol 221 ◽  
pp. 121604
Author(s):  
Emma Daulton ◽  
Alfian N. Wicaksono ◽  
Akira Tiele ◽  
Hemant M. Kocher ◽  
Silvana Debernardi ◽  
...  
Keyword(s):  
Pancreatic Cancer ◽  
Volatile Organic Compounds ◽  
Organic Compounds ◽  
Non Invasive ◽  
Volatile Organic

scholarly journals P252 Urinary volatile organic compounds as a biomarker for pancreatic cancer

2021 ◽  
Author(s):  
James Baker ◽  
Prashant Aggarwal ◽  
Elinor Chapman ◽  
Eithne Costello-Goldring ◽  
Bill Greenhalf ◽  
...  
Keyword(s):  
Pancreatic Cancer ◽  
Volatile Organic Compounds ◽  
Organic Compounds ◽  
Volatile Organic

scholarly journals Non-Invasive Method to Detect Infection with Mycobacterium tuberculosis Complex in Wild Boar by Measurement of Volatile Organic Compounds Obtained from Feces with an Electronic Nose System

Sensors ◽  
2021 ◽  
Vol 21 (2) ◽  
pp. 584
Author(s):  
Kelvin de Jesús Beleño-Sáenz ◽  
Juan Martín Cáceres-Tarazona ◽  
Pauline Nol ◽  
Aylen Lisset Jaimes-Mogollón ◽  
Oscar Eduardo Gualdrón-Guerrero ◽  
...  
Keyword(s):  
Volatile Organic Compounds ◽  
Wild Boar ◽  
Organic Compounds ◽  
Electronic Nose ◽  
Bovine Tuberculosis ◽  
Human Beings ◽  
Non Invasive ◽  
Testing Phase ◽  
Volatile Organic ◽  
Electronic Nose System

More effective methods to detect bovine tuberculosis, caused by Mycobacterium bovis, in wildlife, is of paramount importance for preventing disease spread to other wild animals, livestock, and human beings. In this study, we analyzed the volatile organic compounds emitted by fecal samples collected from free-ranging wild boar captured in Doñana National Park, Spain, with an electronic nose system based on organically-functionalized gold nanoparticles. The animals were separated by the age group for performing the analysis. Adult (>24 months) and sub-adult (12–24 months) animals were anesthetized before sample collection, whereas the juvenile (<12 months) animals were manually restrained while collecting the sample. Good accuracy was obtained for the adult and sub-adult classification models: 100% during the training phase and 88.9% during the testing phase for the adult animals, and 100% during both the training and testing phase for the sub-adult animals, respectively. The results obtained could be important for the further development of a non-invasive and less expensive detection method of bovine tuberculosis in wildlife populations.

P1020 VOLATILE ORGANIC COMPOUNDS IN EXHALED AIR AS POTENTIAL NON-INVASIVE BIOMARKER FOR LIVER CIRRHOSIS

2014 ◽  
Vol 60 (1) ◽  
pp. S415
Author(s):  
K.E. Pijls ◽  
A. Smolinska ◽  
D.M.A.E. Jonkers ◽  
E.J.C. Moonen ◽  
J.W. Dallinga ◽  
...  
Keyword(s):  
Liver Cirrhosis ◽  
Volatile Organic Compounds ◽  
Organic Compounds ◽  
Non Invasive ◽  
Volatile Organic ◽  
Exhaled Air

scholarly journals Screening for SARS-CoV-2 persistence in Long COVID patients using sniffer dogs and scents from axillary sweats samples

2022 ◽  
Author(s):  
Dominique GRANDJEAN ◽  
Dorsaf SLAMA ◽  
Capucine GALLET ◽  
Clothilde JULIEN ◽  
Emilie SEYRAT ◽  
...  
Keyword(s):  
Volatile Organic Compounds ◽  
Organic Compounds ◽  
Non Invasive ◽  
Invasive Test ◽  
Axillary Sweat ◽  
Highly Sensitive ◽  
Volatile Organic ◽  
Sweat Sample ◽  
Asymptomatic Individuals ◽  
Hospital Contact

Objectives: Dogs can be trained to identify several substances not detected by humans, corresponding to specific volatile organic compounds (VOCs). The presence of VOCs, triggered by SARS-CoV-2 infection, was tested in sweat from Long COVID patients. Patients and methods: An axillary sweat sample of Long COVID patients and of COVID-19 negative, asymptomatic individuals was taken at home to avoid any hospital contact. Swabs were randomly placed in olfaction detection cones, and the material sniffed by at least 2 trained dogs. Results: Forty-five Long COVID patients, mean age 45 (6-71), 73.3% female, with prolonged symptoms evolving for a mean of 15.2 months (5-22) were tested. Dogs discriminated in a positive way 23/45 (51.1%) Long COVID patients versus 0/188 (0%) control individuals (p<.0001). Conclusion:This study suggests the persistence of a viral infection in some Long COVID patients and the possibility of providing a simple, highly sensitive, non-invasive test to detect viral presence, during acute and extended phases of COVID-19.

scholarly journals Profile of exhaled-breath volatile organic compounds to diagnose pancreatic cancer

2018 ◽  
Vol 105 (11) ◽  
pp. 1493-1500 ◽  
Author(s):  
S. R. Markar ◽  
B. Brodie ◽  
S.-T. Chin ◽  
A. Romano ◽  
D. Spalding ◽  
...  
Keyword(s):  
Pancreatic Cancer ◽  
Volatile Organic Compounds ◽  
Organic Compounds ◽  
Exhaled Breath ◽  
Volatile Organic

Volatile organic compounds in bile can distinguish pancreatic cancer from chronic pancreatitis: a prospective observational study

Endoscopy ◽  
2020 ◽  
Author(s):  
Udayakumar Navaneethan ◽  
Chad Spencer ◽  
Xiang Zhu ◽  
John J. Vargo ◽  
David Grove ◽  
...  
Keyword(s):  
Pancreatic Cancer ◽  
Chronic Pancreatitis ◽  
Volatile Organic Compounds ◽  
Observational Study ◽  
Organic Compounds ◽  
Prospective Observational Study ◽  
Validation Cohort ◽  
Area Under The Curve ◽  
Endoscopic Retrograde ◽  
Volatile Organic

Abstract Background Early and accurate diagnosis of pancreatic cancer is important. Our aim was to identify potential volatile organic compounds (VOCs) in the bile that can help distinguish pancreatic cancer from chronic pancreatitis. Methods In this prospective observational study, bile was aspirated from patients undergoing endoscopic retrograde cholangiopancreatography for chronic pancreatitis and pancreatic cancer, and the gaseous headspace was analyzed using mass spectrometry. Results The study included a discovery cohort of 57 patients (46 pancreatic cancer, 11 chronic pancreatitis) and a validation cohort of 31 patients (19 and 12, respectively). Using logistic regression analysis, the model [0.158 × age + 9.747 × log (ammonia) – 3.994 × log (acetonitrile) + 5.044 × log (trimethylamine) – 30.23] successfully identified patients with pancreatic cancer with a sensitivity of 93.5 % and specificity of 100 % (likelihood ratio 40.9, area under the curve 0.98, 95 % confidence interval 0.95 – 1.00). The diagnostic accuracy of this model was confirmed in the second independent validation cohort. Conclusion The measurement of VOCs in bile helped to accurately distinguish pancreatic cancer from chronic pancreatitis.

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