Epigenetic mechanisms in atrial fibrillation: New insights and future directions

Alcohol use disorder (AUD) is characterized by clinically significant impairments in health and social function. Epigenetic mechanisms of gene regulation may provide an attractive explanation for how early life exposures to alcohol contribute to the development of AUD and exert lifelong effects on the brain. This chapter provides a critical discussion of the role of epigenetic mechanisms in AUD etiology and the potential of epigenetic research to improve diagnosis, evaluate risks for alcohol-induced pathologies, and promote development of novel therapies for the prevention and treatment of AUD. Challenges of the current epigenetic approaches and future directions are also discussed.

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Heart failure and atrial fibrillation: new concepts in pathophysiology, management, and future directions

Heart Failure Reviews ◽

10.1007/s10741-021-10133-6 ◽

2021 ◽

Author(s):

Grigorios Tsigkas ◽

Anastasios Apostolos ◽

Stefanos Despotopoulos ◽

Georgios Vasilagkos ◽

Eleftherios Kallergis ◽

...

Keyword(s):

Heart Failure ◽

Atrial Fibrillation ◽

Future Directions ◽

New Concepts

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Air Pollution and Atrial Fibrillation: Present Status and Future Directions

Atrial Fibrillation Update: A Textbook of Cardiology ◽

10.5005/jp/books/13034_11 ◽

2017 ◽

pp. 40-40

Author(s):

Geevar Zachariah ◽

Deepak Nandan

Keyword(s):

Atrial Fibrillation ◽

Air Pollution ◽

Present Status ◽

Future Directions

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Genetics of Atrial Fibrillation in 2020

Circulation Research ◽

10.1161/circresaha.120.316575 ◽

2020 ◽

Vol 127 (1) ◽

pp. 21-33 ◽

Cited By ~ 4

Author(s):

Carolina Roselli ◽

Michiel Rienstra ◽

Patrick T. Ellinor

Keyword(s):

Atrial Fibrillation ◽

Complex Disease ◽

Association Studies ◽

Heart Rhythm ◽

Genome Wide Association Studies ◽

Future Directions ◽

Genetics Research ◽

Genome Wide ◽

Increased Risk ◽

Rhythm Disorder

Atrial fibrillation is a common heart rhythm disorder that leads to an increased risk for stroke and heart failure. Atrial fibrillation is a complex disease with both environmental and genetic risk factors that contribute to the arrhythmia. Over the last decade, rapid progress has been made in identifying the genetic basis for this common condition. In this review, we provide an overview of the primary types of genetic analyses performed for atrial fibrillation, including linkage studies, genome-wide association studies, and studies of rare coding variation. With these results in mind, we aim to highlighting the existing knowledge gaps and future directions for atrial fibrillation genetics research.

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Supraventricular Arrhythmias in Athletes: Basic Mechanisms and New Directions

Physiology ◽

10.1152/physiol.00009.2019 ◽

2019 ◽

Vol 34 (5) ◽

pp. 314-326 ◽

Cited By ~ 1

Author(s):

Alicia D’Souza ◽

Tariq Trussell ◽

Gwilym M. Morris ◽

Halina Dobrzynski ◽

Mark R. Boyett

Keyword(s):

Atrial Fibrillation ◽

Animal Models ◽

Heart Block ◽

Research Agenda ◽

Sinus Bradycardia ◽

Vagal Tone ◽

Supporting Evidence ◽

Supraventricular Arrhythmias ◽

Future Directions ◽

New Directions

Athletes are prone to supraventricular rhythm disturbances including sinus bradycardia, heart block, and atrial fibrillation. Mechanistically, this is attributed to high vagal tone and cardiac electrical and structural remodeling. Here, we consider the supporting evidence for these three pro-arrhythmic mechanisms in athletic human cohorts and animal models, featuring current controversies, emerging data, and future directions of relevance to the translational research agenda.

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