Investigation of pathology associated with Chlamydia pecorum infection in the male reproductive tract, and the effect on spermatogenesis and semen quality in the koala (Phascolarctos cinereus)

2021 ◽  
Author(s):  
Lyndal Hulse ◽  
Chiara Palmieri ◽  
Kenneth W. Beagley ◽  
Rebecca Larkin ◽  
Tamara Keeley ◽  
...  
Keyword(s):  
Reproductive Tract ◽  
Semen Quality ◽  
Male Reproductive Tract ◽  
Phascolarctos Cinereus ◽  
Chlamydia Pecorum

scholarly journals Chlamydia pecorum Infection in the Male Reproductive System of Koalas (Phascolarctos cinereus)

2018 ◽  
Vol 56 (2) ◽  
pp. 300-306 ◽  
Author(s):  
Chiara Palmieri ◽  
Lyndal Hulse ◽  
Sara Pagliarani ◽  
Rebecca Larkin ◽  
Damien P. Higgins ◽  
...  
Keyword(s):  
Reproductive System ◽  
Reproductive Tract ◽  
Male Reproductive System ◽  
Chlamydia Infection ◽  
Male Reproductive Tract ◽  
Tissue Samples ◽  
Phascolarctos Cinereus ◽  
Membranous Urethra ◽  
Chlamydia Pecorum ◽  
Serious Disease

Chlamydiosis is the most documented and serious disease of koalas, characterized by ocular, urinary, and reproductive lesions. Since little attention has been paid to the pathological effects of this infection in the male reproductive system, we aimed to determine the incidence and severity of reproductive pathology associated with chlamydial infection in male koalas submitted to koala hospitals in southeast Queensland. The entire reproductive tract from 62 sexually mature male koalas not suitable for rehabilitation was evaluated and 677 tissue samples were collected for histology, immunohistochemistry (IHC), and real-time polymerase chain reaction (qPCR). Lymphoplasmacytic inflammation was observed in 178 of 677 (26.3%) tissue samples from the upper and lower reproductive tract, mainly in the prostatic, penile, and membranous urethra. IHC was positive for the chlamydial antigen in 19 of 451 normal samples (4.2%) and 46 of 178 samples with inflammation (25.8%), located within the cytoplasm of epithelial cells of the epididymis, vas deferens, prostate, bulbourethral glands, and the prostatic membranous and penile urethra. Chlamydia pecorum was detected via qPCR in 319 of 451 normal samples (70.7%) and 159 of 178 samples with inflammation (89.3%), with the highest incidence in the penile urethra, prostate, membranous urethra, and bulbourethral glands. This study suggests that Chlamydia infection in the male reproductive tract is more widespread than originally thought. Furthermore, the male reproductive tract might be a reservoir for persistent chlamydial infections in koalas, with important implications for prophylactic strategies and epidemiology.

Colonisation of the male reproductive tract in asymptomatic infertile men: Effects on semen quality

Andrologia ◽  
2020 ◽  
Vol 52 (7) ◽  
Author(s):  
Ernesto Veiga ◽  
Mercedes Treviño ◽  
Ana B. Romay ◽  
Daniel Navarro ◽  
Rocío Trastoy ◽  
...  
Keyword(s):  
Reproductive Tract ◽  
Semen Quality ◽  
Male Reproductive Tract ◽  
Infertile Men

Chlamydia pecorum Infection in the Reproductive Tract of Female Koalas (Phascolarctos cinereus)

2020 ◽  
Vol 174 ◽  
pp. 189
Author(s):  
S. Pagliarani ◽  
S. Johnston ◽  
M. Pyne ◽  
R. Booth ◽  
L. Hulse ◽  
...  
Keyword(s):  
Reproductive Tract ◽  
Phascolarctos Cinereus ◽  
Chlamydia Pecorum

scholarly journals Environmental anti-androgens and male reproductive health: focus on phthalates and testicular dysgenesis syndrome

Reproduction ◽  
2004 ◽  
Vol 127 (3) ◽  
pp. 305-315 ◽  
Author(s):  
Jane S Fisher
Keyword(s):  
Reproductive Health ◽  
Reproductive Tract ◽  
Semen Quality ◽  
Phthalate Esters ◽  
Male Reproductive Tract ◽  
Testicular Dysgenesis Syndrome ◽  
Geographical Variations ◽  
Human Male ◽  
Testicular Dysgenesis ◽  
Male Reproductive Health

The amount of research into endocrine disruption has exploded over the past decade and a re-evaluation of the state of research in this area is timely. There are debates about whether human male reproductive health is really declining and whether endocrine disrupting chemicals play any role in the perceived decline. Most data currently conclude that there are wide geographical variations in semen quality and in the incidence of testicular cancer, cryptorchidism and hypospadias. This review aims to give a brief overview of the issues surrounding the perceived decline in human male reproductive health and the importance of the hormonal environment for the development of the testis and reproductive tract. The consequences for the male reproductive tract of abnormal androgen levels or action are discussed with reference to environmental anti-androgenic compounds. The in vivo data on several anti-androgenic compounds that have been administered to pregnant rodents during the period of male reproductive tract development are assessed with attention to the effects on the male offspring. Finally, the data on in utero phthalate administration are discussed in detail to illustrate the similarities between the effects of some phthalate esters and the human male reproductive tract disorders which comprise testicular dysgenesis syndrome (TDS).

The Effect of PDE5 Inhibitors on the Male Reproductive Tract

2020 ◽  
Vol 26 ◽  
Author(s):  
Nikolaos Sofikitis ◽  
Aris Kaltsas ◽  
Fotios Dimitriadis ◽  
Jens Rassweiler ◽  
Nikolaos Grivas ◽  
...  
Keyword(s):  
Male Infertility ◽  
Reproductive Tract ◽  
Tunica Albuginea ◽  
Scientific Data ◽  
Secretory Function ◽  
Pde5 Inhibitors ◽  
Male Reproductive Tract ◽  
Review Study ◽  
Phosphodiesterase 5

The therapeutic range of cyclic nucleotide phosphodiesterase 5 inhibitors (PDE5) inhibitors is getting wider in the last years. This review study focuses on the potential employment of PDE5 inhibitors as an adjunct tool for the therapeutic management of male infertility. The literature tends to suggest a beneficial effect of PDE5 inhibitors on Leydig and Sertoli cells secretory function. It also appears that PDE5 inhibitors play a role in the regulation of the contractility of the testicular tunica albuginea and the epididymis. Moreover scientific data suggest that PDE5 inhibitors enhance the prostatic secretory function leading to an improvement in sperm motility. Other studies additionally demonstrate a role of PDE5 inhibitors in the regulation of sperm capacitation process. Placebo-controlled, randomized, blind studies are necessary to unambiguously incorporate PDE5 inhibitors as an adjunct tool for the pharmaceutical treatment of semen disorders and male infertility.

Changes in the Male Reproductive Organs of the Dugong, Dugong dugon (Sirenia: Dugondidae) with Age and Reproductive Activity

1984 ◽  
Vol 32 (6) ◽  
pp. 721 ◽  
Author(s):  
H Marsh ◽  
GE Heinsohn ◽  
TD Glover
Keyword(s):  
Reproductive Tract ◽  
Prostate Gland ◽  
Reproductive Activity ◽  
Reproductive Organs ◽  
Seminal Vesicles ◽  
Growth Layer ◽  
Male Reproductive Tract ◽  
Qualitative And Quantitative ◽  
Quantitative Examination ◽  
Testicular Histology

The anatomy and histology of the male reproductive tract of the dugong (Dugong dugon) is described. Each testis and its adjacent epididymis lie immediately caudal to the corresponding kidney. The seminal vesicles are large but there is no discrete prostate gland and the bulbo-urethral glands are also diffuse. Both qualitative and quantitative examination of the testes and epididymides of 59 males whose ages have been estimated from tusk dentinal growth layer counts indicate that the male dugong does not produce spermatozoa continuously, despite the absence of a distinct breeding season. Individual dugongs were observed with testes at all stages between complete quiescence and full spermatogenesis, and only 10 of the 40 mature males had fully spermatogenic testes and epididymides packed with spermatozoa. Androgenic and spermatogenic activity of the testes appeared to be in phase, but the testicular histology of some old males suggested that they may have been sterile for long periods.

Methyl-parathion bioactivation in the male reproductive tract: From mRNA to protein expression of involved CYP isoforms

2009 ◽  
Vol 189 ◽  
pp. S145
Author(s):  
Betzabet Quintanilla-Vega ◽  
Patricia Espíritu-Gordillo ◽  
Yuliana Palacios-Gil ◽  
Margarita Guaderrama-Díaz ◽  
María de Jesús Solís-Heredia ◽  
...  
Keyword(s):  
Protein Expression ◽  
Methyl Parathion ◽  
Reproductive Tract ◽  
Male Reproductive Tract ◽  
Cyp Isoforms
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