Influence of a low dose of silver nanoparticles on cerebral myelin and behavior of adult rats

During the last few years evidence has accumulated that fetal neurons, implanted into the depth of the brain in adult rats, can reestablish damaged connections in the host brain and substitute functionally for elements lost or damaged as a result of a preceding lesion. This research work has led to the realization that, contrary to traditional views, the adult mammalian CNS has a potential to incorporate new neuronal elements into already established neuronal circuitry and that such implanted neurons can modify the function and behavior of the recipient. For a long time it was thought that the remarkable regenerative and functional potential of CNS tissue grafts that had been demonstrated in cold-blooded vertebrates reflected a fundamental difference in the regenerative properties of central nervous tissue between cold-blooded vertebrates and mammals. During the last few years it has become evident however, that at least certain types of intracerebral neural grafts can perfoum just as well in developing and mammals as in developing or adult submammalian vertebrates.

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Prevention of Progression in Myopia: A Systematic Review

Diseases ◽

10.3390/diseases6040092 ◽

2018 ◽

Vol 6 (4) ◽

pp. 92 ◽

Cited By ~ 7

Author(s):

Aldo Vagge ◽

Lorenzo Ferro Desideri ◽

Paolo Nucci ◽

Massimiliano Serafino ◽

Giuseppe Giannaccare ◽

...

Keyword(s):

Low Dose ◽

Contact Lenses ◽

Rebound Effect ◽

Infectious Keratitis ◽

First Line ◽

Outdoor Activities ◽

Effect Of Treatment ◽

And Behavior ◽

Near Work

The prevalence of myopia has increased worldwide in recent decades and now is endemic over the entire industrial world. This increase is mainly caused by changes in lifestyle and behavior. In particular, the amount of outdoor activities and near work would display an important role in the pathogenesis of the disease. Several strategies have been reported as effective. Spectacles and contact lenses have shown only slight results in the prevention of myopia and similarly ortokerathology should not be considered as a first-line strategy, given the high risk of infectious keratitis and the relatively low compliance for the patients. Thus, to date, atropine ophthalmic drops seem to be the most effective treatment for slowing the progression of myopia, although the exact mechanism of the effect of treatment is still uncertain. In particular, low-dose atropine (0.01%) was proven to be an effective and safe treatment in the long term due to the lowest rebound effect with negligible side effects.

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Review for "Escalating low‐dose Δ 9 ‐tetrahydrocannabinol exposure during adolescence induces differential behavioral and neurochemical effects in male and female adult rats"

10.1111/ejn.14598/v1/review2 ◽

2019 ◽

Author(s):

Cristina Cadoni

Keyword(s):

Low Dose ◽

Female Adult ◽

Adult Rats ◽

Male And Female

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Blood Biochemical and Hematological Study after Subacute Intravenous Injection of Gold and Silver Nanoparticles and Coadministered Gold and Silver Nanoparticles of Similar Sizes

BioMed Research International ◽

10.1155/2018/8460910 ◽

2018 ◽

Vol 2018 ◽

pp. 1-10 ◽

Cited By ~ 2

Author(s):

Ji Hyun Lee ◽

Mary Gulumian ◽

Elaine M. Faustman ◽

Tomomi Workman ◽

KiSoo Jeon ◽

...

Keyword(s):

Silver Nanoparticles ◽

Low Dose ◽

Systemic Toxicity ◽

Blood Biochemistry ◽

Control Group ◽

High Dose ◽

Sprague Dawley ◽

Gold And Silver Nanoparticles ◽

Blood Biochemical ◽

Active Partial Thromboplastin Time

Background. To investigate the effect of subacute intravenous administration AgNP (silver nanoparticles, 10 nm) and AuNP (gold nanoparticles, 12.8 nm) and AgNP/AuNP mixture to blood biochemistry, hematology, and platelet coagulation, subacute toxicity study was conducted. Methods. AuNP and AgNP in which their size distribution was not statistically different, mixed or separate, were injected into the caudal vein of male Sprague-Dawley rats for 4 weeks. The rats were allowed to recover for a further 4 weeks in order to examine systemic toxicity expressed in the blood biochemistry and hematology. The dose groups (5 males per group for the administration and 3 males for the recovery) consisted of 7 divisions, i.e., control, AgNP (with a low dose of 10 μg/kg/day and a high dose of 100 μg/kg/day), AuNP (with a low dose of 10 μg/kg/day and a high dose of 100 μg/kg/day), and mixed AgNP/AuNP (with a low dose of 10/10 μg/kg/day and a high dose of 100/100 μg/kg/day). Results. There were no significant dose-related changes in the hematology and blood biochemical values for the rats. Coagulation time in terms of the active partial thromboplastin time (APTT) and prothrombin time (PT) did not show any significant changes, when compared to the control group. Conclusion. The subacute injection of AuNP and AgNP or their mixture did not induce any noticeable systemic toxicity.

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