Non-invasive assessment of the cardiac effects of Chironex fleckeri and Carukia barnesi venoms in mice, using pulse wave doppler

Toxicon ◽  
2020 ◽  
Vol 185 ◽  
pp. 15-25 ◽  
Author(s):  
Jamie Seymour ◽  
Silvia Saggiomo ◽  
Willis Lam ◽  
Peter Pereira ◽  
Mark Little
Keyword(s):  
Pulse Wave ◽  
Cardiac Effects ◽  
Non Invasive ◽  
Chironex Fleckeri

scholarly journals Differences in Cardiac Effects of Venoms from Tentacles and the Bell of Live Carukia barnesi: Using Non-Invasive Pulse Wave Doppler

Toxins ◽  
2020 ◽  
Vol 13 (1) ◽  
pp. 19
Author(s):  
Mark Little ◽  
Peter Pereira ◽  
Jamie Seymour
Keyword(s):  
Animal Models ◽  
Murine Model ◽  
Real World ◽  
Cardiac Dysfunction ◽  
Pulse Wave ◽  
Cardiac Effects ◽  
Post Exposure ◽  
Non Invasive ◽  
Cardiac Decompensation

Carukia barnesi was the first in an expanding list of cubozoan jellyfish whose sting was identified as causing Irukandji syndrome. Nematocysts present on both the bell and tentacles are known to produce localised stings, though their individual roles in Irukandji syndrome have remained speculative. This research examines differences through venom profiling and pulse wave Doppler in a murine model. The latter demonstrates marked measurable differences in cardiac parameters. The venom from tentacles (CBVt) resulted in cardiac decompensation and death in all mice at a mean of 40 min (95% CL: ± 11 min), whereas the venom from the bell (CBVb) did not produce any cardiac dysfunction nor death in mice at 60 min post-exposure. This difference is pronounced, and we propose that bell exposure is unlikely to be causative in severe Irukandji syndrome. To date, all previously published cubozoan venom research utilised parenterally administered venom in their animal models, with many acknowledging their questionable applicability to real-world envenomation. Our model used live cubozoans on anaesthetised mice to simulate normal envenomation mechanics and actual expressed venoms. Consequently, we provide validity to the parenteral methodology used by previous cubozoan venom research.

Markers of arterial stiffness in peripheral arterial disease

VASA ◽  
2015 ◽  
Vol 44 (5) ◽  
pp. 341-348 ◽  
Author(s):  
Marc Husmann ◽  
Vincenzo Jacomella ◽  
Christoph Thalhammer ◽  
Beatrice R. Amann-Vesti
Keyword(s):  
Arterial Stiffness ◽  
Peripheral Arterial Disease ◽  
Pulse Wave ◽  
Augmentation Index ◽  
Arterial Disease ◽  
Care Physician ◽  
Additional Information ◽  
Non Invasive ◽  
Assessment Techniques ◽  
Peripheral Arterial

Abstract. Increased arterial stiffness results from reduced elasticity of the arterial wall and is an independent predictor for cardiovascular risk. The gold standard for assessment of arterial stiffness is the carotid-femoral pulse wave velocity. Other parameters such as central aortic pulse pressure and aortic augmentation index are indirect, surrogate markers of arterial stiffness, but provide additional information on the characteristics of wave reflection. Peripheral arterial disease (PAD) is characterised by its association with systolic hypertension, increased arterial stiffness, disturbed wave reflexion and prognosis depending on ankle-brachial pressure index. This review summarises the physiology of pulse wave propagation and reflection and its changes due to aging and atherosclerosis. We discuss different non-invasive assessment techniques and highlight the importance of the understanding of arterial pulse wave analysis for each vascular specialist and primary care physician alike in the context of PAD.

ARTERY Society guidelines for validation of non-invasive haemodynamic measurement devices: Part 1, arterial pulse wave velocity

2010 ◽  
Vol 4 (2) ◽  
pp. 34 ◽  
Author(s):  
Ian B. Wilkinson ◽  
Carmel M. McEniery ◽  
Giuseppe Schillaci ◽  
Pierre Boutouyrie ◽  
Patrick Segers ◽  
...  
Keyword(s):  
Pulse Wave Velocity ◽  
Wave Velocity ◽  
Pulse Wave ◽  
Arterial Pulse ◽  
Non Invasive ◽  
Arterial Pulse Wave ◽  
Measurement Devices ◽  
Arterial Pulse Wave Velocity

Non-invasive monitoring of the cardiac effects of continuous intravenous oxytocin infusion during cesarean delivery

2017 ◽  
Vol 139 (2) ◽  
pp. 251-252
Author(s):  
Hiroaki Tanaka ◽  
Kayo Tanaka ◽  
Makoto Tsuji ◽  
Shoichi Magawa ◽  
Fumi Hatano ◽  
...  
Keyword(s):  
Cesarean Delivery ◽  
Invasive Monitoring ◽  
Cardiac Effects ◽  
Non Invasive ◽  
Oxytocin Infusion

Carotid stiffness and atherosclerotic risk: non-invasive quantification with ultrafast ultrasound pulse wave velocity

2018 ◽  
Vol 29 (3) ◽  
pp. 1507-1517 ◽  
Author(s):  
Zheng-Qiu Zhu ◽  
Ling-Shan Chen ◽  
Han Wang ◽  
Fu-Ming Liu ◽  
Yun Luan ◽  
...  
Keyword(s):  
Pulse Wave Velocity ◽  
Wave Velocity ◽  
Pulse Wave ◽  
Non Invasive ◽  
Carotid Stiffness ◽  
Ultrasound Pulse

NON-INVASIVE MEASUREMENT OF HEART-FEMORAL PULSE WAVE VELOCITY

2018 ◽  
Vol 36 (Supplement 1) ◽  
pp. e224
Author(s):  
C. Magistri ◽  
F.U.S. Mattace Raso ◽  
F. Battista ◽  
F. Anastasio ◽  
G. Pucci
Keyword(s):  
Pulse Wave Velocity ◽  
Wave Velocity ◽  
Pulse Wave ◽  
Non Invasive ◽  
Invasive Measurement
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