DNA damage and repair capacity by comet assay in lymphocytes of white-collar active smokers and passive smokers (non- and ex-smokers) at workplace

2006 ◽  
Vol 167 (2) ◽  
pp. 131-141 ◽  
Author(s):  
Maria Enrica Fracasso ◽  
Denise Doria ◽  
Paola Franceschetti ◽  
Luigi Perbellini ◽  
Luciano Romeo
Keyword(s):  
Dna Damage ◽  
Comet Assay ◽  
White Collar ◽  
Repair Capacity ◽  
Dna Damage And Repair

scholarly journals DNA Damage and Repair Capacity in Patients With Lung Cancer: Prediction of Multiple Primary Tumors

2008 ◽  
Vol 26 (21) ◽  
pp. 3560-3566 ◽  
Author(s):  
Irene Orlow ◽  
Bernard J. Park ◽  
Urvi Mujumdar ◽  
Himali Patel ◽  
Puiki Siu-Lau ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Dna Damage ◽  
Comet Assay ◽  
Peripheral Blood Lymphocytes ◽  
Repair Capacity ◽  
Dna Damage And Repair ◽  
Primary Tumors ◽  
Multiple Primary Tumors ◽  
Multiple Primary ◽  
Before And After

PurposePatients who survive one occurrence of non–small-cell lung cancer (NSCLC) are at higher risk of a second malignancy. Capacity to repair damaged DNA may modulate individual susceptibility to develop lung cancer. Therefore, we evaluated constitutive and induced DNA damage, and repair capacity, in patients with multiple NSCLCs (cases) and compared the results to those obtained in patients with a single NSCLC (controls).Patients and MethodsOne hundred eight cases and 99 controls matched by age, sex, and time since diagnosis were studied. DNA damage was assessed on peripheral blood lymphocytes by the comet assay before and after exposing cells to a tobacco-derived carcinogen, using the tail moment and the tail intensity as measures to assess baseline damage, induced damage and repair capacity.ResultsConstitutive DNA damage, benzo(a)pyrene diol epoxide–induced damage, and repair after BPDE-induced damage were all significantly higher in cases than in controls. These results were confirmed in regression analyses adjusted for potential confounders.ConclusionDNA damage as measured by the comet assay is associated with the development of multiple primary tumors in individuals with NSCLC.

DNA damage and repair capacity in lymphocytes from obstructive sleep apnea patients

2007 ◽  
Vol 48 (9) ◽  
pp. 722-727 ◽  
Author(s):  
Konstantina Kontogianni ◽  
Niki Messini-Nikolaki ◽  
Konstantinos Christou ◽  
Konstantinos Gourgoulianis ◽  
Smaragdi Tsilimigaki ◽  
...  
Keyword(s):  
Dna Damage ◽  
Obstructive Sleep Apnea ◽  
Sleep Apnea ◽  
Repair Capacity ◽  
Dna Damage And Repair ◽  
Obstructive Sleep
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