Definition and risk factors of early recurrence based on affecting prognosis of esophageal squamous cell carcinoma patients after radical resection

Abstract Background A nomogram was developed to predict lymph node metastasis (LNM) for patients with early-stage esophageal squamous cell carcinoma (ESCC). Methods We used the clinical data of ESCC patients with pathological T1 stage disease who underwent surgery from January 2011 to June 2018 to develop a nomogram model. Multivariable logistic regression was used to confirm the risk factors for variable selection. The risk of LNM was stratified based on the nomogram model. The nomogram was validated by an independent cohort which included early ESCC patients underwent esophagectomy between July 2018 and December 2019. Results Of the 223 patients, 36 (16.1%) patients had LNM. The following three variables were confirmed as LNM risk factors and were included in the nomogram model: tumor differentiation (odds ratio [OR] = 3.776, 95% confidence interval [CI] 1.515–9.360, p = 0.004), depth of tumor invasion (OR = 3.124, 95% CI 1.146–8.511, p = 0.026), and tumor size (OR = 2.420, 95% CI 1.070–5.473, p = 0.034). The C-index was 0.810 (95% CI 0.742–0.895) in the derivation cohort (223 patients) and 0.830 (95% CI 0.763–0.902) in the validation cohort (80 patients). Conclusions A validated nomogram can predict the risk of LNM via risk stratification. It could be used to assist in the decision-making process to determine which patients should undergo esophagectomy and for which patients with a low risk of LNM, curative endoscopic resection would be sufficient.

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Risk Factors Associated with Esophageal Fistula after Radiotherapy for Esophageal Squamous Cell Carcinoma

International Journal of Radiation Oncology*Biology*Physics ◽

10.1016/j.ijrobp.2019.06.2090 ◽

2019 ◽

Vol 105 (1) ◽

pp. E186

Author(s):

W. Huang

Keyword(s):

Risk Factors ◽

Squamous Cell Carcinoma ◽

Esophageal Squamous Cell Carcinoma ◽

Cell Carcinoma ◽

Squamous Cell ◽

Esophageal Fistula ◽

Factors Associated

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Risk factors of lymph node metastasis in T1 esophageal squamous cell carcinoma

Journal of Gastroenterology and Hepatology ◽

10.1111/j.1440-1746.2007.05259.x ◽

2008 ◽

Vol 23 (4) ◽

pp. 619-625 ◽

Cited By ~ 61

Author(s):

Dong Uk Kim ◽

Jun Haeng Lee ◽

Byung-Hoon Min ◽

Sang Goon Shim ◽

Dong Kyung Chang ◽

...

Keyword(s):

Risk Factors ◽

Squamous Cell Carcinoma ◽

Lymph Node ◽

Lymph Node Metastasis ◽

Esophageal Squamous Cell Carcinoma ◽

Cell Carcinoma ◽

Squamous Cell ◽

Node Metastasis

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A study on p53 gene alterations in esophageal squamous cell carcinoma and their correlation to common dietary risk factors among population of the Kashmir valley

World Journal of Gastroenterology ◽

10.3748/wjg.v12.i25.4033 ◽

2006 ◽

Vol 12 (25) ◽

pp. 4033 ◽

Cited By ~ 30

Author(s):

Imtiyaz Murtaza

Keyword(s):

Risk Factors ◽

Squamous Cell Carcinoma ◽

Esophageal Squamous Cell Carcinoma ◽

Cell Carcinoma ◽

Squamous Cell ◽

P53 Gene ◽

Kashmir Valley ◽

Dietary Risk Factors ◽

Dietary Risk ◽

Gene Alterations

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Risk factors for esophageal fistula in thoracic esophageal squamous cell carcinoma invading adjacent organs treated with definitive chemoradiotherapy: a monocentric case-control study

BMC Cancer ◽

10.1186/s12885-018-4486-3 ◽

2018 ◽

Vol 18 (1) ◽

Cited By ~ 8

Author(s):

Takeshi Kawakami ◽

Takahiro Tsushima ◽

Katsuhiro Omae ◽

Hirofumi Ogawa ◽

Hiromichi Shirasu ◽

...

Keyword(s):

Risk Factors ◽

Squamous Cell Carcinoma ◽

Esophageal Squamous Cell Carcinoma ◽

Cell Carcinoma ◽

Squamous Cell ◽

Case Control Study ◽

Case Control ◽

Esophageal Fistula ◽

Definitive Chemoradiotherapy ◽

Control Study

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Risk factors for esophageal squamous cell carcinoma and its histological precursor lesions in China: a multicenter cross-sectional study

BMC Cancer ◽

10.1186/s12885-021-08764-x ◽

2021 ◽

Vol 21 (1) ◽

Author(s):

Chen Niu ◽

Yong Liu ◽

Jialin Wang ◽

Yuqin Liu ◽

Shaokai Zhang ◽

...

Keyword(s):

Risk Factors ◽

Squamous Cell Carcinoma ◽

Esophageal Squamous Cell Carcinoma ◽

Cell Carcinoma ◽

Squamous Cell ◽

Intraepithelial Neoplasia ◽

Precursor Lesions ◽

Unconditional Logistic Regression ◽

High Incidence ◽

History Of

Abstract Background Despite research efforts, the causative factors that contribute to esophageal squamous cell carcinoma (ESCC) in high-risk areas have not yet been understood. In this study, we, therefore, aimed to describe the risk factors associated with ESCC and its precursor lesions. Methods We performed an endoscopic examination of 44,857 individuals aged 40–69 years from five high incidence regions of China in 2017–2018. Participants were classified as 4 groups of normal control, esophagitis, low-grade intraepithelial neoplasia (LGIN) and high-grade intraepithelial neoplasia/esophageal squamous cell carcinoma (HGIN/ESCC) using an unconditional logistic regression determine risk factors. Results We identified 4890 esophagitis, 1874 LGIN and 437 HGIN/ESCC cases. Crude odds ratios (ORs) and adjusted odds ratios were calculated using unconditional logistic regression. Drinking well and surface water, salty diet, and positive family history of cancer were the common risk factors for esophagitis, LGIN and HGIN/ESCC. History of chronic hepatitis/cirrhosis was the greatest risk factor of esophagitis (adjusted OR 2.96, 95%CI 2.52–3.47) and HGIN/ESCC (adjusted OR 1.91, 95%CI 1.03–3.22). Pesticide exposure (adjusted OR 1.20, 95%CI 1.05–1.37) was essential risk factor of LGIN. Conclusions Among individuals aged 40–69 years in high incidence regions of upper gastrointestinal cancer, the results provided important epidemiological evidence for the prevention of different precancerous lesions of ESCC.

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