Bacteria Isolated From Respiratory Tract Specimens of Renal Recipients With Acute Respiratory Distress Syndrome Due to Pneumonia: Epidemiology and Susceptibility of the Strains

The longer the COVID−19 coronavirus pandemic lasts, the more information about its clinical manifestations is accumulated. The incubation period of COVID−19 ranges from 2 to 14 days, rarely up to 3 weeks, but in a significant number of cases an infection is not accompanied with the appearance of clinical symptoms. Currently, the following variants of the clinical course of COVID−19 can be identified as follows: viral load; subclinical; slight; uncomplicated with damage to only the upper respiratory tract; mild pneumonia, severe pneumonia, acute respiratory distress syndrome, etc. The clinical course of COVID−19 depends on the severity, the criteria of which are the intoxication manifestation, the degree of fever and the dominant syndrome. Mild / moderate forms are manifested by frequent increase in body temperature up to 38 ° C, respiratory symptoms, headache, myalgias, palpitations and general malaise. Patients stop distinguishing smells and feel the taste of food. Approximately from the 7th to the 9th days of the disease there are problems with breathing, which indicates the impairment of the lower respiratory tract and the beginning of the second phase of the disease, and its course is regarded as severe. Severe forms of the disease can also be manifested by impaired coordination of movements, slurred speech. In 1 to 4 % of patients there is developed the psychosis in the form of hallucinations. In the elderly, COVID−19 may be accompanied by delirium, lowering blood pressure. The risks of adverse disease are associated with somatic diseases: cardiovascular and nervous systems, respiratory tract, hormonal disorders, etc. Otitis, sinusitis, sepsis, bronchopulmonary infection, thrombosis, myocarditis etc. can be the complications of COVID−19. Computer tomography is an instrumental test that demonstrates the damage of lungs with coronavirus and allows to assess its severity. Key words: coronavirus infection, COVID−19, clinical variants, severity, pneumonia, acute respiratory distress syndrome.

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Lower Respiratory Tract Infection and Short-Term Outcome in Patients With Acute Respiratory Distress Syndrome

Journal of Intensive Care Medicine ◽

10.1177/0885066618772498 ◽

2018 ◽

Vol 35 (6) ◽

pp. 588-594 ◽

Cited By ~ 3

Author(s):

Fernando G. Zampieri ◽

Pedro Póvoa ◽

Jorge I. Salluh ◽

Alejandro Rodriguez ◽

Sandrine Valade ◽

...

Keyword(s):

Mechanical Ventilation ◽

Acute Respiratory Distress Syndrome ◽

Random Forest ◽

Respiratory Tract ◽

Respiratory Distress Syndrome ◽

Respiratory Distress ◽

Lower Respiratory Tract ◽

Distress Syndrome ◽

Icu Mortality ◽

Mortality Model

Objective: To assess whether ventilator-associated lower respiratory tract infections (VA-LRTIs) are associated with mortality in critically ill patients with acute respiratory distress syndrome (ARDS). Materials and Methods: Post hoc analysis of prospective cohort study including mechanically ventilated patients from a multicenter prospective observational study (TAVeM study); VA-LRTI was defined as either ventilator-associated tracheobronchitis (VAT) or ventilator-associated pneumonia (VAP) based on clinical criteria and microbiological confirmation. Association between intensive care unit (ICU) mortality in patients having ARDS with and without VA-LRTI was assessed through logistic regression controlling for relevant confounders. Association between VA-LRTI and duration of mechanical ventilation and ICU stay was assessed through competing risk analysis. Contribution of VA-LRTI to a mortality model over time was assessed through sequential random forest models. Results: The cohort included 2960 patients of which 524 fulfilled criteria for ARDS; 21% had VA-LRTI (VAT = 10.3% and VAP = 10.7%). After controlling for illness severity and baseline health status, we could not find an association between VA-LRTI and ICU mortality (odds ratio: 1.07; 95% confidence interval: 0.62-1.83; P = .796); VA-LRTI was also not associated with prolonged ICU length of stay or duration of mechanical ventilation. The relative contribution of VA-LRTI to the random forest mortality model remained constant during time. The attributable VA-LRTI mortality for ARDS was higher than the attributable mortality for VA-LRTI alone. Conclusion: After controlling for relevant confounders, we could not find an association between occurrence of VA-LRTI and ICU mortality in patients with ARDS.

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Lower Respiratory Tract Colonization and Infection during Severe Acute Respiratory Distress Syndrome

American Journal of Respiratory and Critical Care Medicine ◽

10.1164/ajrccm.156.4.9701065 ◽

1997 ◽

Vol 156 (4) ◽

pp. 1092-1098 ◽

Cited By ~ 131

Author(s):

CHRISTOPHE DELCLAUX ◽

ERIC ROUPIE ◽

FRANÇOIS BLOT ◽

LAURENT BROCHARD ◽

FRANÇOIS LEMAIRE ◽

...

Keyword(s):

Acute Respiratory Distress Syndrome ◽

Respiratory Tract ◽

Respiratory Distress Syndrome ◽

Respiratory Distress ◽

Lower Respiratory Tract ◽

Distress Syndrome ◽

Respiratory Tract Colonization

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Gemykibivirus Genome in Lower Respiratory Tract of Elderly Woman With Unexplained Acute Respiratory Distress Syndrome

Clinical Infectious Diseases ◽

10.1093/cid/ciz072 ◽

2019 ◽

Vol 69 (5) ◽

pp. 861-864 ◽

Cited By ~ 2

Author(s):

Jian Wang ◽

Yanpeng Li ◽

Xi He ◽

Jinmin Ma ◽

Wenxin Hong ◽

...

Keyword(s):

Acute Respiratory Distress Syndrome ◽

Respiratory Tract ◽

Respiratory Distress Syndrome ◽

Respiratory Distress ◽

Respiratory Disease ◽

Lower Respiratory Tract ◽

Elderly Woman ◽

Distress Syndrome ◽

Metagenomics Analysis

Abstract Using metagenomics analysis, we are the first to identify the presence of a small, circular, single-stranded Gemykibivirus (GkV) genome from the respiratory tract of an elderly woman with severe acute respiratory distress syndrome. Our results suggest that further studies on whether GkVs infect humans and cause respiratory disease are needed.

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Neutrophil extracellular traps persist at high levels in the lower respiratory tract of critically ill COVID-19 patients

The Journal of Infectious Diseases ◽

10.1093/infdis/jiab053 ◽

2021 ◽

Author(s):

Werner J D Ouwendijk ◽

Matthijs P Raadsen ◽

Jeroen J A van Kampen ◽

Robert M Verdijk ◽

Jan H von der Thusen ◽

...

Keyword(s):

Acute Respiratory Distress Syndrome ◽

Respiratory Tract ◽

Respiratory Distress Syndrome ◽

Respiratory Distress ◽

Critically Ill ◽

Inflammatory Markers ◽

Lower Respiratory Tract ◽

Distress Syndrome ◽

Neutrophil Extracellular Traps ◽

Extracellular Traps

Abstract SARS-CoV-2 induced lower respiratory tract (LRT) disease can deteriorate to acute respiratory distress syndrome (ARDS). Because the release of neutrophil extracellular traps (NETs) is implicated in ARDS pathogenesis, we investigated the presence of NETs and correlates of pathogenesis in blood and LRT samples of critically ill COVID-19 patients. Plasma NET levels peaked early after ICU admission and correlated with SARS-CoV-2 RNA load in sputum and levels of neutrophil-recruiting chemokines and inflammatory markers in plasma. Baseline plasma NET quantity correlated with disease severity, but was not associated with soluble markers of thrombosis nor with development of thrombosis. High NET levels were present in LRT samples and persisted during the course of COVID-19, consistent with the detection of NETs in bronchi and alveolar spaces in lung tissue from fatal COVID-19 patients. Thus, NETs are produced and retained in the LRT of critical COVID-19 patients and could contribute to SARS-CoV-2-induced ARDS pathology.

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Tension Pneumomediastinum: A life-threatening condition in COVID-19 Patients

10.22541/au.161932814.48385850/v1 ◽

2021 ◽

Author(s):

Nissar Shaikh ◽

Gamal Al Ameri ◽

Muhsen Shaheen ◽

Wael Abdaljawad ◽

Sujith Prabhakaran ◽

...

Keyword(s):

Acute Respiratory Distress Syndrome ◽

Respiratory Tract ◽

Respiratory Distress Syndrome ◽

Respiratory Distress ◽

Distress Syndrome ◽

Clinical Entity ◽

Threatening Condition ◽

Life Threatening ◽

Increased Pressure

Tension pneumomediastinum (TPM) is a rare but potentially fatal clinical entity. This leads to leakage of air into the mediastinal cavity and increased pressure on thoracic vessels, respiratory tract, and the heart. We report a series of five cases of COVID-19 complicating into acute respiratory distress syndrome and developing TPM.

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A Series of Five Adult Cases of Respiratory Syncytial Virus-Related Acute Respiratory Distress Syndrome

Anaesthesia and Intensive Care ◽

10.1177/0310057x0803600214 ◽

2008 ◽

Vol 36 (2) ◽

pp. 230-234 ◽

Cited By ~ 6

Author(s):

D. Robert ◽

D. Verbiest ◽

H. Demey ◽

M. Ieven ◽

H. Jansens ◽

...

Keyword(s):

Acute Respiratory Distress Syndrome ◽

Respiratory Syncytial Virus ◽

Respiratory Failure ◽

Respiratory Tract ◽

Respiratory Distress Syndrome ◽

Respiratory Distress ◽

Distress Syndrome ◽

Lavage Fluid ◽

Therapeutic Interventions ◽

Syncytial Virus

Respiratory syncytial virus is a common cause of respiratory tract disease in children, predominantly presenting with mild symptoms. We present five cases of respiratory syncytial virus infection of the lower respiratory tract in immunocompromised adults suffering from severe respiratory insufficiency leading to bilateral pneumonia and fulfilling the criteria for acute respiratory distress syndrome. Respiratory syncytial virus was cultured as the only pathogen in the bronchoalveolar lavage fluid in four of these patients. Despite various therapeutic interventions, only one patient survived. Respiratory syncytial virus was implicated as a direct cause of respiratory failure. Respiratory syncytial virus may be an underestimated cause of severe respiratory failure and acute respiratory distress syndrome in the immunocompromised adult admitted to the intensive care unit.

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Aspergillus-positive lower respiratory tract samples in patients with the acute respiratory distress syndrome: a 10-year retrospective study

Annals of Intensive Care ◽

10.1186/s13613-016-0156-2 ◽

2016 ◽

Vol 6 (1) ◽

Cited By ~ 8

Author(s):

Damien Contou ◽

Matthieu Dorison ◽

Jérémy Rosman ◽

Frédéric Schlemmer ◽

Aude Gibelin ◽

...

Keyword(s):

Acute Respiratory Distress Syndrome ◽

Retrospective Study ◽

Respiratory Tract ◽

Respiratory Distress Syndrome ◽

Respiratory Distress ◽

Lower Respiratory Tract ◽

Distress Syndrome

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SARS-CoV-2 receptor mutation in Egyptian population

10.1101/2020.04.27.20082206 ◽

2020 ◽

Author(s):

Mohamed M Hafez ◽

Zeinab K Hassan ◽

Abeer A. Bahnasy ◽

Ola S. Ahmed ◽

Mohamed Abouelhoda ◽

...

Keyword(s):

Infectious Disease ◽

Acute Respiratory Distress Syndrome ◽

Severe Acute Respiratory Syndrome ◽

Respiratory Tract ◽

Respiratory Distress Syndrome ◽

Respiratory Distress ◽

Distress Syndrome ◽

Severe Pneumonia ◽

Viral Receptor ◽

Egyptian Population

AbstractThe Coronavirus disease 2019 (COVID-19) is a respiratory tract infectious disease caused by Severe Acute Respiratory Syndrome coronavirus 2 (SARS-CoV-2). SARS-CoV-2 triggers severe pneumonia leading to acute respiratory distress syndrome and death in severe cases. According to WHO reported, Egypt is among the countries with low confirmed SARS CoV2 infected symptomatic cases and death. We postulate that one of the reasons for this may be due mutations in the viral receptor. Therefore this study was conducted to confirm or reject this postulation.

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