Background: The pathologies associated with impacted maxillary canine tooth presented as radiolucent, radiopaque and mixed radiolucent radiopaque lesions on radiographs and adenomatoid odontogenic tumor was the most common pathology associated with it followed by dentigerous cyst, odontoma and calcifying odontogenic cyst after histopathological confirmation. This study was planned to determine the frequency of pathologies associated with impacted maxillary canine tooth in patients presenting at a tertiary care hospital.Methods: This cross-sectional survey was conducted at Dental / Oral Surgery Department, Shaikh Zayed Medical College / Hospital, Rahim Yar Khan, Pakistan from January to December 2017. A total of 60 patients with clinical and radiographic diagnosis of impacted maxillary canine tooth were enrolled. Orthopantomogram and/or para nasal sinus view were considered as the standard radiograph for assessment of pathologies associated with impacted maxillary canine tooth which were confirmed by histopathological examination. Demographics and radiographic findings and histopathological confirmation of pathologies were noted.Results: Out of a total of 60 patients, 38 (63.33%) pathologies associated with impacted maxillary canine presented as radiolucent lesion, 11 (18.33%) each presented as radiopaque and mixed radiolucent radiopaque lesion. Adenomatoid odontogenic tumor (30%) was the most common pathology associated with impacted maxillary canine tooth. The other pathologies associated were dentigerous cyst (26.67%), odontoma (18.33%), calcifying odontogenic cyst (11.66%), calcifying odontogenic cyst with an odonotoma (6.66%), Odontogenic keratocyst (3.33%) and Ameloblastoma (3.33%).Conclusions: The most common pathology occurring predominantly with impacted maxillary canine tooth was adenomatoid odontogenic tumor followed by dentigerous cyst, odontoma and calcifying odontogenic cyst.