Background:
The therapeutic strategies to manage neurodegenerative diseases remain
limited and it is necessary to discover new agents for their prevention and control. Oxidative stress
and inflammation play a main role in the pathogenesis of neurodegenerative diseases. The aim of
this study is to review the effects of green tea catechins against the Neurodegenerative Diseases.
Methods:
In this study, we extensively reviewed all articles on the terms of Green tea, catechins,
CNS disorders, and different diseases in PubMed, Science Direct, Scopus, and Google Scholar
databases between the years 1990 and 2017.
Results:
The present study found that catechins, the major flavonoids in green tea, are powerful
antioxidants and radical scavengers which possess the potential roles in the management of
neurodegenerative diseases. Catechins modulate the cellular and molecular mechanisms through the
inflammation-related NF-κB and the nuclear factor erythroid 2-related factor 2 (Nrf2) signaling
pathways.
Conclusion:
The findings of the present review shows catechins could be effective against
neurodegenerative diseases due to their antioxidation and anti-inflammation effects and the involved
biochemical pathways including Nrf2 and NF-kB signaling pathways.<P>
Wheather green tea catechins could have a protective effect in overactive bladder rats induced by high-sugar high-fat diet and ovariectomy？