Cationic liposome–DNA complexes (CLDC) adjuvant enhances the immunogenicity and cross-protective efficacy of a pre-pandemic influenza A H5N1 vaccine in mice

Vaccine ◽  
2012 ◽  
Vol 30 (2) ◽  
pp. 254-264 ◽  
Author(s):  
Libo Dong ◽  
Feng Liu ◽  
Jeffery Fairman ◽  
David K. Hong ◽  
David B. Lewis ◽  
...  
Keyword(s):  
Pandemic Influenza ◽  
Influenza A ◽  
Protective Efficacy ◽  
Cationic Liposome ◽  
Dna Complexes ◽  
H5n1 Vaccine

scholarly journals A cationic liposome–DNA complexes adjuvant (JVRS-100) enhances the immunogenicity and cross-protective efficacy of pre-pandemic influenza A (H5N1) vaccine in ferrets

Virology ◽  
2016 ◽  
Vol 492 ◽  
pp. 197-203 ◽  
Author(s):  
Feng Liu ◽  
Xiangjie Sun ◽  
Jeffery Fairman ◽  
David B. Lewis ◽  
Jacqueline M. Katz ◽  
...  
Keyword(s):  
Pandemic Influenza ◽  
Influenza A ◽  
Protective Efficacy ◽  
Cationic Liposome ◽  
Dna Complexes ◽  
H5n1 Vaccine

scholarly journals An Adjuvanted, Low‐Dose, Pandemic Influenza A (H5N1) Vaccine Candidate Is Safe, Immunogenic, and Induces Cross‐Reactive Immune Responses in Healthy Adults

2008 ◽  
Vol 198 (5) ◽  
pp. 642-649 ◽  
Author(s):  
Karin Levie ◽  
Isabel Leroux‐Roels ◽  
Karel Hoppenbrouwers ◽  
Anne‐Diane Kervyn ◽  
Corinne Vandermeulen ◽  
...  
Keyword(s):  
Immune Responses ◽  
Pandemic Influenza ◽  
Influenza A ◽  
Low Dose ◽  
Vaccine Candidate ◽  
Healthy Adults ◽  
H5n1 Vaccine

scholarly journals Persistence of Antibody to Influenza A/H5N1 Vaccine Virus: Impact of AS03 Adjuvant

2015 ◽  
Vol 23 (1) ◽  
pp. 73-77 ◽  
Author(s):  
Wilbur H. Chen ◽  
Lisa A. Jackson ◽  
Kathryn M. Edwards ◽  
Wendy A. Keitel ◽  
Heather Hill ◽  
...  
Keyword(s):  
Influenza Virus ◽  
Pandemic Influenza ◽  
Influenza A ◽  
Vaccine Virus ◽  
H5n1 Vaccine

ABSTRACTThe adjuvant AS03 is stockpiled for future formulations with new and existing vaccines for the control of pandemic influenza virus. We previously reported the immunogenicity of an A/H5N1 vaccine extemporaneously mixed with the AS03 adjuvant for 42 days following vaccination. This report extends those findings to 1 year after vaccination.

scholarly journals Safety and immunogenicity of influenza A(H5N1) vaccine stored up to twelve years in the National Pre-Pandemic Influenza Vaccine Stockpile (NPIVS)

Vaccine ◽  
2019 ◽  
Vol 37 (3) ◽  
pp. 435-443 ◽  
Author(s):  
Christine M. Oshansky ◽  
James Zhou ◽  
Yonghong Gao ◽  
Jo Ellen Schweinle ◽  
Karen Biscardi ◽  
...  
Keyword(s):  
Influenza Vaccine ◽  
Pandemic Influenza ◽  
Influenza A ◽  
H5n1 Vaccine

scholarly journals Expression of Surfactant protein D (SP-D) distinguishes severe pandemic influenza A(H1N1) from COVID-19

2021 ◽  
Author(s):  
José Alberto Choreño-Parra ◽  
Luis Armando Jiménez-Álvarez ◽  
Gustavo Ramírez-Martínez ◽  
Alfredo Cruz-Lagunas ◽  
Mahima Thapa ◽  
...  
Keyword(s):  
Pandemic Influenza ◽  
Influenza A ◽  
Alveolar Epithelium ◽  
Surfactant Protein ◽  
High Serum ◽  
Surfactant Protein D ◽  
Diagnostic Challenge ◽  
Moderate Disease ◽  
Influenza A H1n1 ◽  
Novel Biomarkers

Abstract The differentiation of influenza and COVID-19 could constitute a diagnostic challenge during the ongoing winter due to their clinical similitude. Thus, novel biomarkers that enable distinguishing both diseases are required. Here, we evaluated whether the surfactant protein D (SP-D), a collectin produced at the alveolar epithelium with known immune properties, was useful to differentiate pandemic influenza A(H1N1) from COVID-19 in critically ill patients. Our results revealed high serum SP-D levels in severe pandemic influenza but not COVID-19 patients. This finding was validated in a separate cohort of mechanically ventilated COVID-19 patients who also showed low plasma SP-D levels. However, plasma SP-D levels did not distinguish seasonal influenza from COVID-19 in mild-to-moderate disease. Finally, we found that high serum SP-D levels were associated with mortality and renal failure among severe pandemic influenza cases. Thus, our studies have identified SP-D as a unique biomarker expressed during severe pandemic influenza but not COVID-19.

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