Prevention of perinatal hepatitis B virus transmission in the Netherlands, 2003–2007: Children of Chinese mothers are at increased risk of breakthrough infection

Hepatitis B virus (HBV) infection represents a serious global health problem and persistent HBV infection is associated with an increased risk of cirrhosis, hepatocellular carcinoma and liver failure. Recently, the study of the role of microRNA (miRNA) in the pathogenesis of HBV has gained considerable interest as well as new treatments against this pathogen have been approved. A few studies have investigated the antiviral activity of vitamin E (VE) in chronic HBV carriers. Herein, we review the possible role of tocopherols in the modulation of host miRNA with potential anti-HBV activity. A systematic research of the scientific literature was performed by searching the MEDLINE, Cochrane Library and EMBASE databases. The keywords used were ‘HBV therapy’, ‘HBV treatment’, ‘VE antiviral effects’, ‘tocopherol antiviral activity’, ‘miRNA antiviral activity’ and ‘VE microRNA’. Reports describing the role of miRNA in the regulation of HBV life cycle,in vitroandin vivoavailable studies reporting the effects of VE on miRNA expression profiles and epigenetic networks, and clinical trials reporting the use of VE in patients with HBV-related chronic hepatitis were identified and examined. Based on the clinical results obtained in VE-treated chronic HBV carriers, we provide a reliable hypothesis for the possible role of this vitamin in the modulation of host miRNA profiles perturbed by this viral pathogen and in the regulation of some cellular miRNA with a suggested potential anti-HBV activity. This approach may contribute to the improvement of our understanding of pathogenetic mechanisms involved in HBV infection and increase the possibility of its management and treatment.

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Prevention of perinatal hepatitis B virus transmission by combined passive–active immunoprophylaxis in Iwate, Japan (1981–1992) and epidemiological evidence for its efficacy

Hepatology Research ◽

10.1016/s1386-6346(03)00168-2 ◽

2003 ◽

Vol 26 (4) ◽

pp. 287-292 ◽

Cited By ~ 29

Author(s):

T Koyama

Keyword(s):

Hepatitis B Virus ◽

Hepatitis B ◽

Virus Transmission ◽

Epidemiological Evidence ◽

B Virus

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Hepatitis B virus transmission by blood donation negative for hepatitis B surface antigen, antibody to HBsAg, antibody to hepatitis B core antigen and HBV DNA

Vox Sanguinis ◽

10.1046/j.1423-0410.2001.00089.x ◽

2001 ◽

Vol 81 (2) ◽

pp. 140-140 ◽

Cited By ~ 14

Author(s):

B. C. Dow ◽

M. A. Peterkin ◽

R. H. A. Green ◽

S. O. Cameron

Keyword(s):

Hepatitis B Virus ◽

Hepatitis B ◽

Blood Donation ◽

Hepatitis B Surface Antigen ◽

Virus Transmission ◽

Hbv Dna ◽

Core Antigen ◽

B Virus ◽

Hepatitis B Core Antigen ◽

Antigen Antibody

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Single Nucleotide Polymorphisms in IFN-γ Signaling Pathway Associated with Risk of Hepatitis B Virus Infection in Chinese Children

Canadian Journal of Infectious Diseases and Medical Microbiology ◽

10.1155/2020/8121659 ◽

2020 ◽

Vol 2020 ◽

pp. 1-8

Author(s):

Yang Zhuo ◽

Yalan Yang ◽

Mingjun Zhang ◽

Ying Xu ◽

Zhongping Chen ◽

...

Keyword(s):

Hepatitis B Virus ◽

Hepatitis B ◽

Single Nucleotide Polymorphisms ◽

Signaling Pathway ◽

Public Health Problem ◽

Hbv Infection ◽

Nucleotide Polymorphisms ◽

Breakthrough Infection ◽

Single Nucleotide ◽

B Virus

Hepatitis B virus (HBV) infection is a challenging public health problem in China and worldwide. Mother-to-child transmission is one of the main transmission routes of HBV in highly endemic regions. However, the mechanisms of HBV perinatal transmission in children have not been clearly defined. The aim of this study was to demonstrate the association between single-nucleotide polymorphisms (SNPs) in IFN-γ signaling pathway and HBV infection or breakthrough infection in children. Two hundred and seventy-four HBV-infected children defined as test positive for hepatitis B surface antigen (HBsAg) and 353 controls defined as negative for HBsAg in China were recruited from October 2013 to May 2015. SNPs in IFN-γ signaling pathway including IFNG, IFNGR1, IFNGR2, and IL12B were genotyped. Rs2234711 in IFNGR1 was significantly associated with HBV infection in children (OR = 0.641, 95% CI: 0.450–0.913). In addition, rs2234711 was also significantly associated with HBV breakthrough infection in children born to HBsAg-positive mothers (OR = 0.452, 95% CI: 0.205–0.998). Our study confirmed that genetic variants in IFN-γ signaling pathway have significant associations with HBV infection, especially with HBV breakthrough in children. This study provides insight into HBV infection in children and could be used to help design effective strategies for reducing immunoprophylaxis failure.

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Selecting a Genetic Region for Molecular Analysis of Hepatitis B Virus Transmission

Journal of Clinical Microbiology ◽

10.1128/jcm.02046-06 ◽

2007 ◽

Vol 45 (2) ◽

pp. 687-689 ◽

Cited By ~ 8

Author(s):

S. Datta ◽

A. Banerjee ◽

P. K. Chandra ◽

R. Chakravarty ◽

B. C. Cowie

Keyword(s):

Hepatitis B Virus ◽

Hepatitis B ◽

Molecular Analysis ◽

Virus Transmission ◽

Genetic Region ◽

B Virus

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Increased risk of hip fracture associated with dually treated HIV/hepatitis B virus coinfection

Journal of Viral Hepatitis ◽

10.1111/jvh.12398 ◽

2015 ◽

Vol 22 (11) ◽

pp. 936-947 ◽

Cited By ~ 8

Author(s):

D. D. Byrne ◽

C. W. Newcomb ◽

D. M. Carbonari ◽

M. S. Nezamzadeh ◽

K. B. F. Leidl ◽

...

Keyword(s):

Hip Fracture ◽

Hepatitis B Virus ◽

Hepatitis B ◽

Increased Risk ◽

B Virus

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Factors associated with self-reported hepatitis B virus vaccination status among men who have sex with men in the Netherlands

Sexual Health ◽

10.1071/sh20082 ◽

2020 ◽

Vol 17 (5) ◽

pp. 444

Author(s):

C. Den Daas ◽

P. C. G. Adam ◽

K. Vermey ◽

W. Zuilhof ◽

J. B. F. de Wit

Keyword(s):

Health Promotion ◽

Hepatitis B Virus ◽

Hepatitis B ◽

The Netherlands ◽

Vaccination Status ◽

Factors Associated ◽

Hbv Vaccination ◽

B Virus ◽

Sex With Men ◽

Health Promotion Interventions

Background Reducing the number of new acute hepatitis B virus (HBV) infections to zero by 2022 is an important goal in the Netherlands. Free HBV vaccination is available for population groups at higher risk of infection, including men who have sex with men (MSM). Identifying correlates of HBV vaccination among MSM can guide the development of health promotion interventions to increase coverage of HBV vaccination. Methods: We assessed factors associated with the HBV vaccination status of 4270 MSM in the Netherlands. Data were collected through the 2018 online Men & Sexuality survey. Results: Multinomial regression analysis showed that lower education level, having never tested for HIV, not recently diagnosed with a sexually transmissible infection, recently having had sex abroad and unknown HBV testing status were associated with higher odds of being unvaccinated as opposed to fully vaccinated. Living in Amsterdam and testing HBV negative were associated with lower odds of being unvaccinated as opposed to fully vaccinated. Age (25–39 years vs younger ages), living in Amsterdam and using pre-exposure prophylaxis decreased the odds to be partly vaccinated as opposed to fully vaccinated; having a migration background increased these odds. Conclusions: HBV vaccination rates among MSM will not reduce HBV transmission to zero. HBV promotion should focus on MSM outside of Amsterdam who are likely less connected with sexual health services and may be at lower (perceived) risk. The factors identified related to HBV vaccination status provide guidance for health promotion interventions to increase uptake and vaccination completion among MSM.

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