uHeart: A beating heart-on-chip platform for on-line recording of functional 3D cardiac microtissues' electrical activity

2020 ◽  
Vol 105 ◽  
pp. 106809
Author(s):  
Roberta Visone ◽  
Simona Marzorati ◽  
Valeria Perego ◽  
Paola Occhetta ◽  
Enrico Pesenti ◽  
...  
Keyword(s):  
Electrical Activity ◽  
Beating Heart ◽  
On Line ◽  
On Chip

scholarly journals A Stochastic Model to Describe the Scattering in the Response of Polysilicon MEMS

2021 ◽  
Vol 2 (1) ◽  
pp. 95
Author(s):  
Luca Dassi ◽  
Marco Merola ◽  
Eleonora Riva ◽  
Angelo Santalucia ◽  
Andrea Venturelli ◽  
...  
Keyword(s):  
Silicon Film ◽  
Micro Fabrication ◽  
Micro Electro Mechanical Systems ◽  
Local Fluctuations ◽  
Stochastic Framework ◽  
On Line ◽  
Chip Testing ◽  
On Chip ◽  
Time Required ◽  
Polycrystalline Silicon Film

The current miniaturization trend in the market of inertial microsystems is leading to movable device parts with sizes comparable to the characteristic length-scale of the polycrystalline silicon film morphology. The relevant output of micro electro-mechanical systems (MEMS) is thus more and more affected by a scattering, induced by features resulting from the micro-fabrication process. We recently proposed an on-chip testing device, specifically designed to enhance the aforementioned scattering in compliance with fabrication constraints. We proved that the experimentally measured scattering cannot be described by allowing only for the morphology-affected mechanical properties of the silicon films, and etch defects must be properly accounted for too. In this work, we discuss a fully stochastic framework allowing for the local fluctuations of the stiffness and of the etch-affected geometry of the silicon film. The provided semi-analytical solution is shown to catch efficiently the measured scattering in the C-V plots collected through the test structure. This approach opens up the possibility to learn on-line specific features of the devices, and to reduce the time required for their calibration.

scholarly journals Micro-electrode channel guide (µECG) technology: an online method for continuous electrical recording in a human beating heart-on-chip

2021 ◽  
Vol 13 (3) ◽  
pp. 035026
Author(s):  
Roberta Visone ◽  
Giovanni S Ugolini ◽  
Daniela Cruz-Moreira ◽  
Simona Marzorati ◽  
Stefano Piazza ◽  
...  
Keyword(s):  
Beating Heart ◽  
Electrical Recording ◽  
On Chip

scholarly journals Organ-on-Chip: Playing LEGO® With Mini-Organs to Reduce Animal Testing and Make Medicines Safer

2020 ◽  
Vol 8 ◽  
Author(s):  
Julia Rogal ◽  
Madalena Cipriano ◽  
Peter Loskill
Keyword(s):  
Animal Experiments ◽  
Beating Heart ◽  
Laboratory Animals ◽  
Fat Tissue ◽  
Animal Testing ◽  
Small Plastic ◽  
The Future ◽  
On Chip ◽  
Better Than

Have you ever pictured yourself as a LEGO®-mini-figure? That is pretty cool, right?! But now, instead of picturing yourself as an astronaut, superhero, or elf-figure, try to imagine your own body being miniature and built from LEGO®–one brick for each of your organs. Sound weird? Let us explain why a mini LEGO®-version of you could be extremely useful and could become reality in the future. Such technology might help end testing that uses laboratory animals and help your doctors understand your disease. We use people’s cells and small plastic housings to build mini-organs the size of small LEGO®-bricks, such as a beating heart or energy-storing fat tissue. Similar to playing LEGO®, we can also connect different organ-bricks and study how they talk and work with each other. In this article, we will tell you how this all works and why it is so much better than animal experiments.

scholarly journals User-friendly, magnetically sealed plug-and-play sensor module for online electrochemical sensing for fluidic devices

2021 ◽  
Author(s):  
Amanda Roley ◽  
Kaylee Clark ◽  
Alec Richardson ◽  
Brandaise Martinez ◽  
Stuart Tobet ◽  
...  
Keyword(s):  
Time Course ◽  
Electrochemical Sensors ◽  
Redox System ◽  
Electrochemical Sensing ◽  
Flow Conditions ◽  
Plug And Play ◽  
Sensor Module ◽  
Fluidic Devices ◽  
On Line ◽  
On Chip

The growth in fluidic devices, such as organ-on-chip (OOC) technology, comes with a need for growth in sensing capabilities of key biomolecules to help elucidate changes during the time course of experiments. We developed an on-line, easy-to-assemble, 3D-printed electrochemical sensor module that is magnetically sealed for ease of assembly. The sensor module includes a plug-and-play format for electrochemical sensors made in finger-tight fittings to allow for a wide selection of experimental set-ups and target molecules. Here, we report the feasibility of the sensor module as well as demonstrate its use for electrochemical sensing with integrated thermoplastic electrodes (TPEs). The sensor module withstood over 300 kPa of backpressure and demonstrated reliable performance with TPEs when using cyclic voltammetry (CV) and amperometry under flow conditions. CVs using the ferri/ferrocyanide (K3/4[Fe(CN)6]) redox system demonstrate that the sensor module does not hinder the expected linear response with respect to analyte concentration. Further CVs and amperometry demonstrated the use of the sensor module under flow conditions. Such success in device design and usability is promising for future work using the on-line sensor module with a variety of applications.

On-Line Analysis of Stuck-at Faults in On-Chip Network Interconnects

2018 ◽  
Vol 27 (13) ◽  
pp. 1850203 ◽  
Author(s):  
Biswajit Bhowmik ◽  
Jatindra Kumar Deka ◽  
Santosh Biswas
Keyword(s):  
Performance Metrics ◽  
Test Scheme ◽  
On Line ◽  
On Chip ◽  
Line Analysis

Reliability has become a major concern when link-wires in on-chip networks (NoCs) suffer from stuck-at faults (SAFs). This paper presents an extended and scalable test scheme that addresses these faults in NoC links to improve yield and reliability. The scheme detects the stuck-at faults on and identifies faulty link-wires. Experiments demonstrate the effectiveness of the proposed scheme and reveal deep insights of the faults on several performance metrics.

An Investigation of the Cutting Process for Chip Breaking Monitoring in Turning of Steels

1998 ◽  
Vol 120 (3) ◽  
pp. 555-562 ◽  
Author(s):  
W. Grzesik ◽  
P. Bernat
Keyword(s):  
Frequency Domain ◽  
Control Factor ◽  
Interface Temperature ◽  
State Monitoring ◽  
Chip Breaking ◽  
Interface Control ◽  
Orthogonal Machining ◽  
Wide Range ◽  
On Line ◽  
On Chip

This paper presents some results of an experimental study on chip breaking monitoring when turning steels with chip forming inserts. In the first part of this study the recognition of chip forms by means of cutting force analysis in the frequency domain is described. Generally, the present work is concerned with the use of the interface control factor for determining the transition from unacceptable chip forms to the chip breaking. For this purpose experiments under approximately orthogonal machining conditions including measuring the shear strain, the cutting energy and the average interface temperature are carried out. The obtained results confirmed that the initiation of acceptable chip breaking for a wide range of cutting conditions and the three steels used could be predicted in terms of an appropriate energy consumption rate. An architecture for on-line cutting state monitoring system based on signal processing procedure in the frequency domain is developed and the performance of the system is experimentally evaluated.

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