scholarly journals Age- and airway disease related gene expression patterns of key SARS-CoV-2 entry factors in human nasal epithelia

Virology ◽  
2021 ◽  
Author(s):  
Mihkel Plaas ◽  
Kadri Seppa ◽  
Nayana Gaur ◽  
Priit Kasenõmm ◽  
Mario Plaas
iScience ◽  
2021 ◽  
Vol 24 (4) ◽  
pp. 102357
Author(s):  
Brenda Morsey ◽  
Meng Niu ◽  
Shetty Ravi Dyavar ◽  
Courtney V. Fletcher ◽  
Benjamin G. Lamberty ◽  
...  

2016 ◽  
Vol 17 (12) ◽  
pp. 1990 ◽  
Author(s):  
Shun Chen ◽  
Anqi Wang ◽  
Lipei Sun ◽  
Fei Liu ◽  
Mingshu Wang ◽  
...  

Neuroreport ◽  
2002 ◽  
Vol 13 (7) ◽  
pp. 953-956 ◽  
Author(s):  
Kathy Keyvani ◽  
Otto W. Witte ◽  
Sonja Reinecke ◽  
Werner Paulus

BMC Genomics ◽  
2014 ◽  
Vol 15 (1) ◽  
pp. 968 ◽  
Author(s):  
Karl-Magnus Andersson ◽  
Dharmendra Kumar ◽  
Johan Bentzer ◽  
Eva Friman ◽  
Dag Ahrén ◽  
...  

2021 ◽  
Author(s):  
Mihkel Plaas ◽  
Kadri Seppa ◽  
Nayana Gaur ◽  
Priit Kasenomm ◽  
Mario Plaas

The global COVID-19 pandemic caused by SARS-CoV-2 predominantly affects the elderly. Differential expression of SARS-CoV-2 entry genes may underlie the variable susceptibility in different patient groups. Here, we examined the gene expression of key SARS-CoV-2 entry factors in mucosal biopsies to delineate the roles of age and existing chronic airway disease. A significant inverse correlation between ACE2 and age and a downregulation of NRP1 in patients with airway disease were noted. These results indicate that the interplay between various factors may influence susceptibility and the disease course.


2017 ◽  
Vol 28 ◽  
pp. v597-v598
Author(s):  
L. Molinero ◽  
J. Albanell ◽  
H. Koeppen ◽  
E. Martinez de Dueñas ◽  
D. Halligan ◽  
...  

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