Recurrent partial seizures with ictal yawning as atypical presentation of Hashimoto's encephalopathy (steroid-responsive encephalopathy associated with autoimmune thyroiditis)

2011 ◽  
Vol 22 (4) ◽  
pp. 799-803 ◽  
Author(s):  
S. Casciato ◽  
C. Di Bonaventura ◽  
L. Lapenta ◽  
J. Fattouch ◽  
G. Ferrazzano ◽  
...  
Keyword(s):  
Autoimmune Thyroiditis ◽  
Atypical Presentation ◽  
Partial Seizures ◽  
Hashimoto’S Encephalopathy

scholarly journals Hashimoto’s encephalopathy in a patient with septal panniculitis: a case report

Reumatismo ◽  
2018 ◽  
Vol 70 (4) ◽  
pp. 268-269
Author(s):  
C. Cosso ◽  
M. Ghio ◽  
M. Cutolo
Keyword(s):  
Case Report ◽  
Autoimmune Thyroiditis ◽  
Behavioral Changes ◽  
Glucocorticoid Therapy ◽  
Thyroid Antibodies ◽  
Mental Confusion ◽  
Hashimoto’S Encephalopathy

Hashimoto’s encephalopathy (HE) is an autoimmune form of encephalopathy, associated with autoimmune thyroiditis. Its prevalence is estimated to be 2:100,000. HE is characterized by behavioral changes, mental confusion, dysarthria, ataxia, psychosis, paranoia, convulsions, hallucinations, headache and hyperthermia. Elevated thyroid antibodies are necessary for diagnosis and the disease responds dramatically to glucocorticoid therapy. We describe a patient with HE and panniculitis, an association reported twice in the literature.

Hashimotos Encephalopathy: unusual manifestation of a common disorder

JMS SKIMS ◽  
2020 ◽  
Vol 23 (2) ◽  
Author(s):  
Javaid Ahmad Bhat ◽  
Junaid Rashid Dar ◽  
Mohammad Hayat Bhat ◽  
Waseem Qureshi
Keyword(s):  
Steroid Therapy ◽  
Autoimmune Thyroiditis ◽  
Graves Disease ◽  
Thyroid Status ◽  
Unusual Manifestation ◽  
Hashimoto’S Encephalopathy ◽  
Altered Sensorium ◽  
Common Disorder ◽  
Psychiatric Manifestations

Hashimoto's encephalopathy is a steroid responsive encephalopathy usually seen in association with autoimmune thyroiditis independent of the thyroid status. However; its association with Graves’ disease is rare. Here, we present a case of HE associated with Graves’ disease. The patient presented with altered sensorium with varied psychiatric manifestations and went into rapid remission after steroid therapy.

scholarly journals Hashimoto's Encephalopathy Masquerading as Rapidly Progressive Dementia and Extrapyramidal Failure

2022 ◽  
Author(s):  
Yasser Aladdin ◽  
Bader Shirah
Keyword(s):  
Autoimmune Thyroiditis ◽  
Delayed Diagnosis ◽  
Thyroid Antibodies ◽  
Cerebral Damage ◽  
Serological Testing ◽  
Progressive Dementia ◽  
Rare Presentation ◽  
Hashimoto’S Encephalopathy ◽  
Immune Mediated ◽  
Underlying Pathogenesis

AbstractHashimoto's encephalopathy is a rare immune-mediated disorder characterized by subacute encephalopathy with elevated thyroid antibodies. Hashimoto's encephalopathy is also known as steroid-responsive encephalopathy associated with autoimmune thyroiditis. We report a rare presentation of Hashimoto's encephalopathy presenting with acute neuropsychiatric disturbances, rapidly progressive dementia, seizures, and extrapyramidal failure. Neuroimaging revealed multifocal vasculitides of major cerebral vessels that support the autoimmune vasculitic theory as the underlying pathogenesis for Hashimoto's encephalopathy. Unfortunately, permanent irreversible cerebral damage has already ensued before her presentation to our center, which rendered steroid therapy ineffective. Serological testing for Hashimoto's thyroiditis must be in the investigation of all rapidly progressive dementias as early diagnosis and timely management of autoimmune thyroiditis may salvage sizable and eloquent cerebral tissues. The rarity of the condition should not preclude the investigation of Hashimoto's disease even in the presence of normal levels of thyroid hormones. Delayed diagnosis may result in irreversibly catastrophic encephalopathy in patients who once presented with potentially curable dementia.

A SREATable Encephalopathy

2018 ◽  
pp. 61-64
Author(s):  
Aaron E. Miller ◽  
Tracy M. DeAngelis ◽  
Michelle Fabian ◽  
Ilana Katz Sand
Keyword(s):  
Cognitive Decline ◽  
Autoimmune Thyroiditis ◽  
Therapeutic Response ◽  
Thyroid Peroxidase ◽  
Antithyroid Antibodies ◽  
Hashimoto’S Encephalopathy ◽  
Mri Brain ◽  
Csf Analysis ◽  
Eeg Abnormalities ◽  
Diagnostic Clue

Steroid-responsive encephalopathy associated with autoimmune thyroiditis (SREAT), more commonly known as Hashimoto’s encephalopathy, is a rare, poorly understood, and probably under-diagnosed disorder. SREAT is characterized by a progressive cognitive decline, with neuropsychiatric features and possible seizures, myoclonus, and tremors in association with the presence of anti-thyroid, anti-thyroid peroxidase (TPO) and/or anti-thyroglobulin (TG) antibodies. Importantly, alternative explanations for encephalopathy must be excluded. There are no specific clinical, radiographic, or EEG abnormalities. MRI brain and CSF analysis can be normal. Antithyroid antibodies, either in serum or CSF, provide the key diagnostic clue but are not clearly pathogenic. The hallmark of SREAT is an excellent therapeutic response to steroids.

scholarly journals Thyroid Autoantibodies in the Cerebrospinal Fluid of Subjects with and without Thyroid Disease: Implications for Hashimoto’s Encephalopathy

2015 ◽  
Vol 2015 ◽  
pp. 1-4 ◽  
Author(s):  
Ioannis Ilias ◽  
Vasiliki Karagiorga ◽  
George Paraskevas ◽  
Anastasia Bougea ◽  
Mara Bourbouli ◽  
...  
Keyword(s):  
Cerebrospinal Fluid ◽  
Immune System ◽  
Autoimmune Thyroiditis ◽  
Thyroid Disease ◽  
Statistical Significance ◽  
Thyroid Autoantibodies ◽  
Healthy Individuals ◽  
Thyroglobulin Antibodies ◽  
Hashimoto’S Encephalopathy ◽  
Antithyroid Autoantibodies

Introduction. Plasma antithyroid peroxidase (anti-TPO) and anti-thyroglobulin antibodies (anti-Tg) are widely used in the diagnosis of autoimmune thyroiditis. No research has compared anti-TPO and anti-Tg both in plasma and cerebrospinal fluid (CSF) of healthy individuals vis-à-vis patients with thyroid disease.Methods. We measured anti-TPO and anti-Tg antibodies in plasma and CSF in nine subjects (mean age ± SD: 73 ± 6 years) with hypothyroidism and nine subjects (mean age ± SD: 73 ± 8 years) without thyroid disease.Results. The concentration of anti-TPO autoantibodies in CSF was very low compared to plasma in both subjects with thyroid and without thyroid disease (P=0.007). CSF anti-Tg autoantibodies titers were very low compared to the plasma in subjects with thyroid disease (P=0.004), whereas, in subjects without thyroid disease, this difference did not reach statistical significance (P=0.063).Conclusions. Thyroid autoantibodies levels were low in plasma and CSF; we did not observe any transfer of thyroid autoantibodies from the peripheral blood to the CSF. Therefore, regarding Hashimoto’s encephalopathy, where elevated antithyroid autoantibodies are often measured in blood, it is more likely that thyroiditis and encephalopathy represent nonspecific, but distinct, events of an aggressive immune system.

scholarly journals Steroid-Responsive Encephalopathy Associated with Autoimmune Thyroiditis Presenting as Confusion, Dysphasia, and Myoclonus

2012 ◽  
Vol 2012 ◽  
pp. 1-2 ◽  
Author(s):  
S. A. Ryan ◽  
C. Kennedy ◽  
H. J. Harrington
Keyword(s):  
Clinical Features ◽  
Autoimmune Thyroiditis ◽  
Complete Response ◽  
Altered Level ◽  
Hashimoto’S Encephalopathy ◽  
The Core ◽  
Immune Mediated ◽  
Level Of Consciousness ◽  
Laboratory Results ◽  
Core Features

Steroid response encephalopathy associated with autoimmune thyroiditis (SREAT), or Hashimoto’s encephalopathy, is a rare disorder believed to be immune-mediated. It is most often characterized by a subacute onset of confusion with altered level of consciousness, seizures, and myoclonus. We describe the case of a 48-year-old gentleman who presented with confusion and dysphasia. Specific clinical features and laboratory results led to a diagnosis of Hashimoto’s encephalopathy. This case highlights the core features of this condition and the potential for complete response to steroid therapy.

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