scholarly journals Thyroid Autoantibodies in the Cerebrospinal Fluid of Subjects with and without Thyroid Disease: Implications for Hashimoto’s Encephalopathy

2015 ◽  
Vol 2015 ◽  
pp. 1-4 ◽  
Author(s):  
Ioannis Ilias ◽  
Vasiliki Karagiorga ◽  
George Paraskevas ◽  
Anastasia Bougea ◽  
Mara Bourbouli ◽  
...  
Keyword(s):  
Cerebrospinal Fluid ◽  
Immune System ◽  
Autoimmune Thyroiditis ◽  
Thyroid Disease ◽  
Statistical Significance ◽  
Thyroid Autoantibodies ◽  
Healthy Individuals ◽  
Thyroglobulin Antibodies ◽  
Hashimoto’S Encephalopathy ◽  
Antithyroid Autoantibodies

Introduction. Plasma antithyroid peroxidase (anti-TPO) and anti-thyroglobulin antibodies (anti-Tg) are widely used in the diagnosis of autoimmune thyroiditis. No research has compared anti-TPO and anti-Tg both in plasma and cerebrospinal fluid (CSF) of healthy individuals vis-à-vis patients with thyroid disease.Methods. We measured anti-TPO and anti-Tg antibodies in plasma and CSF in nine subjects (mean age ± SD: 73 ± 6 years) with hypothyroidism and nine subjects (mean age ± SD: 73 ± 8 years) without thyroid disease.Results. The concentration of anti-TPO autoantibodies in CSF was very low compared to plasma in both subjects with thyroid and without thyroid disease (P=0.007). CSF anti-Tg autoantibodies titers were very low compared to the plasma in subjects with thyroid disease (P=0.004), whereas, in subjects without thyroid disease, this difference did not reach statistical significance (P=0.063).Conclusions. Thyroid autoantibodies levels were low in plasma and CSF; we did not observe any transfer of thyroid autoantibodies from the peripheral blood to the CSF. Therefore, regarding Hashimoto’s encephalopathy, where elevated antithyroid autoantibodies are often measured in blood, it is more likely that thyroiditis and encephalopathy represent nonspecific, but distinct, events of an aggressive immune system.

Thyroid autoantibodies: A good marker for the study of symptomless autoimmune thyroiditis

1987 ◽  
Vol 114 (3) ◽  
pp. 321-327 ◽  
Author(s):  
C. Betterle ◽  
G. Callegari ◽  
F. Presotto ◽  
F. Zanette ◽  
B. Pedini ◽  
...  
Keyword(s):  
Autoimmune Diseases ◽  
Alopecia Areata ◽  
Autoimmune Thyroiditis ◽  
Normal Population ◽  
Thyroid Autoantibodies ◽  
Thyroid Disorders ◽  
Trh Test ◽  
Thyroglobulin Antibodies ◽  
Good Marker ◽  
Observation Period

Abstract. In 3737 subjects without clinically thyroid disorders we evaluated the incidence of thyroid microsomal and thyroglobulin antibodies. These autoantibodies were found in 7% of a normal population, in 9% of patients with various non-autoimmune diseases, and in 11–16% of groups who either had or were at risk for autoimmune diseases: patients with IDDM, vitiligo, alopecia areata, idiopathic hypoparathyroidism, Addison's disease, and first-degree relatives of IDDM patients. Functional thyroid evaluation with TRH test was performed in 197 seropositive subjects and 144 seronegative controls. One-quarter (26%) of the subjects with thyroid autoantibodies showed functional abnormalities on TRH testing, whereas only 2.8% of the 144 seronegative controls showed subclinical hypothyroidism. After an observation period of 12–44 months, 102 persistently seropositive subjects were reassessed and 31% of them showed an impairment in TRH test response.

scholarly journals ANTITHYROID ANTIBODIES - A POSSIBLE INVOLVEMENT IN THE DEVELOPMENT OF CHRONIC PERIODONTITIS

2021 ◽  
Vol 68 (2) ◽  
pp. 278-285
Author(s):  
Razvan Circo ◽  
◽  
Marian Beciu ◽  
Doina Raducan ◽  
Victoria Badea ◽  
...  
Keyword(s):  
Serum Level ◽  
Autoimmune Thyroiditis ◽  
Chronic Periodontitis ◽  
Statistical Significance ◽  
Mean Value ◽  
Dental Occlusion ◽  
Thyroid Autoantibodies ◽  
Spontaneous Bleeding ◽  
Chronic Autoimmune Thyroiditis ◽  
Normal Thyroid Function

Objectives. Identification of periodontal lesions in patients with chronic autoimmune thyroiditis (CAT) assessed differently depending on their severity and the average serum level of thyroid autoantibodies. Material and methods. The study was initiated in a group of patients (n = 133) diagnosed with chronic autoimmune thyroiditis in conditions of normal thyroid function and without other comorbidities. Examination of the oral cavity identified lesions characteristic of chronic periodontitis (CP) classified according to their intensity in - mild, medium and aggravated in a group of 109 patients. The serum level of thyroid autoantibodies – as a mean value – was analyzed in a group of 77 patients with similar periodontal lesions related to their classification. Results. Characteristic ethological changes of chronic periodontitis were identified in 85% of patients being classified as: mild (40.2%), medium (31.9%), aggravated (28.5%). Thyroid autoantibodies were present: 62.3% for antithyroperoxidase antibodies (ATPO), 23.8% for both ATPO and antithyroglobulin antibodies (ATG); 13.7% for ATG. The differentiated statistical calculation of the average values of antibodies found for ATPO presented a high statistical significance (p < 0.0002) for spontaneous bleeding, all degrees of tooth mobility, depth of periodontal pockets, root fork and dental occlusion. No statistical significance was found for ATPO in bacterial plaque and gingival regression. No statistical significance was recorded for the mean level of ATG. Conclusions. The correlation of the serum level of thyroid autoantibodies with the specificity of periodontal lesions certify a possible differentiated involvement of them. For ATPO, extra-thyroid systemic effects can be suggested as a priority.

scholarly journals Study of gustatory sensitivity to phenylthiocarbamide in thyroid diseases

2009 ◽  
Vol 55 (2) ◽  
pp. 45-47
Author(s):  
A F Malenchenko ◽  
E S Makhlina ◽  
V V Tatchikhin ◽  
I V Khlusova ◽  
N D Lukovskaya
Keyword(s):  
Thyroid Cancer ◽  
Autoimmune Thyroiditis ◽  
Thyroid Disease ◽  
Thyroid Diseases ◽  
Healthy Individuals ◽  
Cancer Group ◽  
Male Patients

The aim of the study was to reveal a relationship between gustatory sensitivity to phenylthiocarbamide (PTC) and thyroid disease. The distribution of PTC sensitivity was studied in 198 healthy individuals, 100 patients with autoimmune thyroiditis (AIT), 139 patients with nodular euthyroid goiter, and 100 patients operated on for thyroid cancer. There was a statistically significant decrease in the number of PTC-resistant male and females patients in the thyroid cancer group and an increase in the proportion of PTC-resistant male patients in the AIT and nodular euthyroid goiter groups.

scholarly journals Chronic periodontitis in a group of patients with chronic autoimmune thyroiditis – particularities of expression

2021 ◽  
Vol 68 (1) ◽  
pp. 92-101
Author(s):  
Răzvan Circo ◽  
◽  
Cristina Gosu ◽  
Victoria Badea ◽  
◽  
...  
Keyword(s):  
Linear Regression ◽  
Autoimmune Thyroiditis ◽  
Thyroid Disease ◽  
Statistical Significance ◽  
Statistical Correlation ◽  
Pathological Process ◽  
Periodontal Status ◽  
Autoimmune Thyroid ◽  
Chronic Autoimmune Thyroiditis ◽  
Group 1

Objectives. The intricacy of the inflammatory / infiltrative process common to chronic autoimmune thyroid disease and periodontal disease (CP) justifies the study of the incidence and expression peculiarities of periodontal lesions encountered in patients with chronic autoimmune thyroiditis (CAT). The presence of periodontal plaque correlated with the oral hygiene index represents a proof of the microbial aggression, as a "trigger" in initiating the pathological process with a progressive evolution. Material and method. The study included patients with CP: group 1 – associating CAT, group 2 – without thyroid disease. The periodontal status was assessed: mild, medium, aggravated. Statistically correlated variables: periodontal lesions, sex, age of patients, OHI-s, thyroid functional status (TSH), serum level of thyroid autoantibodies (ATPO / ATg) and antinuclear antibodies (ANA). Results. A heterogeneity of the distribution of periodontal lesions in both groups was found. The preponderance of lesions with statistical significance (p < 0.001) predominated for study group 1. Aggravated periodontal status: more common in group 1 (p = 0.043), was not influenced by the sex of the patients. The monofactorial linear regression finds the average interdependence between the OHI-s value and the age of the patients (r = 0.63; p = 0.018) and the TSH problem (r = 0.55; p = 0.0003). The multifactorial linear regression, however, attests a direct proportional relationship between OHI-s and TSH, ATPO, ATg (r = 0.56; p = 0.001) and intensified with age (r = 0.78, p <0.001). Effect on OHI-s calculated by ANOVA test: ATPO (Pr = 78.66%; r = 0.73; p = 0.05); ATg (Pr = 94.06%; r = 0.73; p = 0.042); both antibodies (Pr = 96.28%, r = 0.87; p = 0.003), correlated with age (r = 0.99; p <0.001). No statistical correlation for ANA was found. Conclusions. The presence and progressive characteristics of CP in patients with CAT attests the etiopathogenic interference of the two diseases and requests an interdisciplinary therapeutic attitude.

Hashimoto encephalopathy

2013 ◽  
Vol 154 (33) ◽  
pp. 1312-1316 ◽  
Author(s):  
Gábor Pocsay ◽  
Andrea Gazdag ◽  
József Engelhardt ◽  
István Szaniszló ◽  
Zoltán Szolnoki ◽  
...  
Keyword(s):  
Psychiatric Symptoms ◽  
Immunosuppressive Treatment ◽  
Unknown Origin ◽  
Corticosteroid Treatment ◽  
Thyroid Peroxidase ◽  
Thyroid Autoantibodies ◽  
Thyroglobulin Antibodies ◽  
Hashimoto Encephalopathy ◽  
Generalized Seizures

The authors present a case report and review the literature on Hashimoto encephalopathy. The onset of the disease may be marked by focal and then progressively generalized seizures or other neurological symptoms, but a cognitive decline or various psychiatric symptoms may also emerge. High levels of anti-thyroid peroxidase antibodies and/or anti-thyroglobulin antibodies are present in the serum. Corticosteroid treatment usually results in an improvement of symptoms. The syndrome is frequently overlooked and, therefore, the authors strongly recommend testing serum thyroid autoantibodies in cases with encephalopathy of unknown origin independently on the presence of thyroid disease in the patient or family history. The importance of long-term immunosuppressive treatment should also be stressed. Orv. Hetil., 2013, 154, 1312–1316.

XMODULATION IN MICEAND MEN: IL-10 PRODUCING CELLS INBLOOD AND LYMPHOID TISSUE

2008 ◽  
Vol 31 (4) ◽  
pp. 3
Author(s):  
L Barrett ◽  
M Grant ◽  
R Liwski ◽  
K West
Keyword(s):  
Immune System ◽  
Peripheral Blood ◽  
Lymphoid Tissue ◽  
Mononuclear Cells ◽  
Ex Vivo ◽  
White Blood Cells ◽  
Interleukin 10 ◽  
Healthy Individuals ◽  
Human Immune System ◽  
Healthy Humans

Background: The human immune system provides remarkable protection from a plethora of pathogens, but can cause damage when activated for a prolonged time (as inpersistent infections) or against self (autoimmunity). Therefore, mechanisms of immune system downregulation and control are imperative. There is little data on how the immune system is controlled in healthy individuals. We recently described a novel population of white blood cells that constitutively produce the immunomodulatory cytokine interleukin-10 (IL-10). Our objective was to further delineate the distribution of these cells in human and mouse models, as well as potential triggers for interleukin-10 production in vitro. Methods: Human and animal protocols were reviewed and approved by the institutional ethics board and animal care facilities, and informed consent was obtained from all human donors. The ex vivo percentage of peripheral blood CD36^+IL-10^+ mononuclear cells was assessed by intracellular flow cytometry in 10 healthy individuals. IL-10 production after exposure to twoCD36 ligands, thrombospondin and oxidized low density lipoprotein (oxLDL) was measured at 8 hours. Peripheral blood mononuclear cells and splenocytes from BL/6 (n=5) and Balb/c (n=1) micewere assessed for CD36^+IL-10^+ cells ex vivo as well. Results: The percentage of CD36^+IL-10^+ cells in peripheral blood fromhealthy individuals ranges between 0.1% and 0.9%. The percentage was similar in mouse peripheral blood, with a range of 0.4%-1.1%. These cells were also found in mouse spleen at a higher frequency than peripherally (1.1-1.5%). Human CD36^+IL-10^+ cells have more IL-10 when exposed to thrombospondin, oxLDL. Conclusions: Our novel population of IL-10 producing cells is found not only in healthy humans, but also in lymphoid tissue and blood from pathogen free mice. This highlights the evolutionary conservation of the cell across species, and suggests an important homeostatic function. The physiologic ligands for CD36 are ubiquitous in circulation, and ourin vitro data suggests a link between CD36 ligation and IL-10 production. IL-10 is a known immune system modulator, and its production by these cells may help maintain homeostaticcontrol of the immune system.

scholarly journals The Relationships between HIV-1 Infection, History of Methamphetamine Use Disorder, and Soluble Biomarkers in Blood and Cerebrospinal Fluid

Viruses ◽  
2021 ◽  
Vol 13 (7) ◽  
pp. 1287
Author(s):  
T. Walter ◽  
Jennifer Iudicello ◽  
Debra Cookson ◽  
Donald Franklin ◽  
Bin Tang ◽  
...  
Keyword(s):  
Cerebrospinal Fluid ◽  
Immune System ◽  
Public Health Problem ◽  
Control Group ◽  
Csf Biomarkers ◽  
Immune System Dysfunction ◽  
Immune Biomarkers ◽  
Plasma Factor ◽  
History Of ◽  
Hiv 1

Methamphetamine (METH) use disorder is highly prevalent among people with HIV (PWH) and is a significant public health problem. HIV and METH use are each associated with immune system dysfunction; however, the combined effects on the immune system are poorly understood. This cross-sectional project measured soluble immune biomarkers in plasma and cerebrospinal fluid (CSF) collected from a control group, people with a history of a METH use disorder (METH+), PWH with no history of METH use disorder (HIV+), and PWH with a history of METH use disorder (HIV+/METH+). HIV, METH, and immune dysfunction can also be associated with affective and cognitive deficits, so we characterized mood and cognition in our participants. Two factor analyses were performed for the plasma and CSF biomarkers. Plasma IL-8, Ccl2, VEGF, and 8-isoprostane loaded onto one factor that was highest in the HIV+/METH+ group (p < 0.047) reflecting worse inflammation, vascular injury, and oxidative stress. This plasma factor was also negatively correlated with delayed recall (R = −0.49, p = 0.010), which was worst in the HIV+/METH+ group (p = 0.030 compared to the control group). Overall, these data implicate that combined HIV-1 infection and METH use may exacerbate inflammation, leading to worse cognition.

scholarly journals Sex and race differences of cerebrospinal fluid metabolites in healthy individuals

Metabolomics ◽  
2021 ◽  
Vol 17 (2) ◽  
Author(s):  
Zackery W. Reavis ◽  
Nikhil Mirjankar ◽  
Srikant Sarangi ◽  
Stephen H. Boyle ◽  
Cynthia M. Kuhn ◽  
...  
Keyword(s):  
Cerebrospinal Fluid ◽  
Race Differences ◽  
Healthy Individuals

Does Xbox 360 Kinect training improve postural balance in young healthy adults? A preliminary study. (Preprint)

2021 ◽  
Author(s):  
Marta Grabowicz ◽  
Anna Daniluk ◽  
Anna Hadamus ◽  
Dariusz Białoszewski
Keyword(s):  
Postural Balance ◽  
Statistical Significance ◽  
Balance Training ◽  
The Body ◽  
Control Group ◽  
Healthy Individuals ◽  
Unstable Surface ◽  
Baseline Group ◽  
Before And After ◽  
P Balance

BACKGROUND Balance training in young adults may increase coordination, cognitive function or the symmetry of strength on both sides of the body. It is an essential tool for injury or fall prevention and a precondition for becoming a professional athlete. OBJECTIVE The aim of this study was to assess the effect of Xbox 360 Kinect training on postural balance in young, healthy individuals. METHODS The study enrolled 75 individuals who were randomly assigned to three equal groups. The first group (Group VR) performed exercises on an Xbox 360 Kinect console, and the second group (Group T) performed conventional all-round exercises. The third group was a control group (Group C). Each group underwent balance assessments on the Biodex Balance posturographic platform, including the Balance Error Scoring System test, before and after the training cycle. The level of statistical significance was set at P<.05. RESULTS Group VR and Group T achieved statistically significant improvements in the sway index compared with baseline. Group T gained significant decrease in the sway index on the unstable surface (P=.002). Group VR and group T demonstrated significant decreases in the mean sway index on stable and unstable surfaces (group VR — P=.035; group T — P=.001) Group C did not achieve a statistically significant improvement in the sway index. None of the groups demonstrated a statistically significant decrease in the test error count. CONCLUSIONS Virtual reality in the form of video games played on an Xbox 360 Kinect console may be an effective method of balance training in healthy individuals.

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