MiR-18a regulates the proliferation, migration and invasion of human glioblastoma cell by targeting neogenin

2014 ◽  
Vol 324 (1) ◽  
pp. 54-64 ◽  
Author(s):  
Yichen Song ◽  
Ping Wang ◽  
Wei Zhao ◽  
Yilong Yao ◽  
Xiaobai Liu ◽  
...  
Keyword(s):  
Migration And Invasion ◽  
Glioblastoma Cell ◽  
Human Glioblastoma ◽  
Human Glioblastoma Cell

Silencing of Eps8 blocks migration and invasion in human glioblastoma cell lines

2012 ◽  
Vol 318 (15) ◽  
pp. 1901-1912 ◽  
Author(s):  
Maria Grazia Cattaneo ◽  
Elisa Cappellini ◽  
Lucia M. Vicentini
Keyword(s):  
Cell Lines ◽  
Migration And Invasion ◽  
Glioblastoma Cell ◽  
Human Glioblastoma ◽  
Human Glioblastoma Cell ◽  
Glioblastoma Cell Lines

scholarly journals Dihydrotestosterone Induces Proliferation, Migration, and Invasion of Human Glioblastoma Cell Lines

2020 ◽  
Vol Volume 13 ◽  
pp. 8813-8823 ◽  
Author(s):  
Dulce Carolina Rodríguez-Lozano ◽  
Diana Elisa Velázquez-Vázquez ◽  
Aylin Del Moral-Morales ◽  
Ignacio Camacho-Arroyo
Keyword(s):  
Cell Lines ◽  
Migration And Invasion ◽  
Glioblastoma Cell ◽  
Human Glioblastoma ◽  
Human Glioblastoma Cell ◽  
Glioblastoma Cell Lines

The effect of type III collagen on migration and invasion of human glioblastoma cell lines in vitro

1996 ◽  
Vol 102 (1-2) ◽  
pp. 57-63 ◽  
Author(s):  
Shravan Kumar Chintala ◽  
Raymond Sawaya ◽  
Ziya Levent Gokaslan ◽  
Jasti Sambasiva Rao
Keyword(s):  
Cell Lines ◽  
Migration And Invasion ◽  
Type Iii Collagen ◽  
Glioblastoma Cell ◽  
Human Glioblastoma ◽  
Human Glioblastoma Cell ◽  
Type Iii ◽  
Glioblastoma Cell Lines

scholarly journals Knockdown of FRAT1 Expression by RNA Interference Inhibits Human Glioblastoma Cell Growth, Migration and Invasion

PLoS ONE ◽  
2013 ◽  
Vol 8 (4) ◽  
pp. e61206 ◽  
Author(s):  
Geng Guo ◽  
Dong Kuai ◽  
Sang Cai ◽  
Naizhao Xue ◽  
Yueting Liu ◽  
...  
Keyword(s):  
Rna Interference ◽  
Cell Growth ◽  
Migration And Invasion ◽  
Glioblastoma Cell ◽  
Human Glioblastoma ◽  
Human Glioblastoma Cell

scholarly journals WNK2 Inhibits Autophagic Flux in Human Glioblastoma Cell Line

Cells ◽  
2020 ◽  
Vol 9 (2) ◽  
pp. 485
Author(s):  
Ana Laura Vieira Alves ◽  
Angela Margarida Costa ◽  
Olga Martinho ◽  
Vinicius Duval da Silva ◽  
Peter Jordan ◽  
...  
Keyword(s):  
Cell Line ◽  
Suppressor Gene ◽  
Migration And Invasion ◽  
Autophagic Flux ◽  
Glioblastoma Cell Line ◽  
Glioblastoma Cell ◽  
Human Glioblastoma ◽  
Human Glioblastoma Cell Line ◽  
Human Glioblastoma Cell ◽  
Protein Levels

Autophagy is a cell-survival pathway with dual role in tumorigenesis, promoting either tumor survival or tumor death. WNK2 gene, a member of the WNK (with no lysine (K)) subfamily, acts as a tumor suppressor gene in gliomas, regulating cell migration and invasion; however, its role in autophagy process is poorly explored. The WNK2-methylated human glioblastoma cell line A172 WT (wild type) was compared to transfected clones A172 EV (empty vector), and A172 WNK2 (WNK2 overexpression) for the evaluation of autophagy using an inhibitor (bafilomycin A1—baf A1) and an inducer (everolimus) of autophagic flux. Western blot and immunofluorescence approaches were used to monitor autophagic markers, LC3A/B and SQSTM1/p62. A172 WNK2 cells presented a significant decrease in LC3B and p62 protein levels, and in LC3A/B ratio when compared with control cells, after treatment with baf A1 + everolimus, suggesting that WNK2 overexpression inhibits the autophagic flux in gliomas. The mTOR pathway was also evaluated under the same conditions, and the observed results suggest that the inhibition of autophagy mediated by WNK2 occurs through a mTOR-independent pathway. In conclusion, the evaluation of the autophagic process demonstrated that WNK2 inhibits the autophagic flux in glioblastoma cell line.

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