Comparative proteomic profiles of paired cervical cancer and paracancerous tissue and the effects of DUSP7 over-expression on SIHA cell line through inhibiting RAS pathway

2020 ◽  
Vol 159 ◽  
pp. 195
Author(s):  
X. Jiang ◽  
H. Bai ◽  
J. Li ◽  
S. Wang
Keyword(s):  
Cervical Cancer ◽  
Cell Line ◽  
Siha Cell ◽  
Ras Pathway ◽  
Over Expression ◽  
Siha Cell Line

Physicochemical Characterization of Curcumin Loaded Chitosan Nanoparticles: Implications in Cervical Cancer

2018 ◽  
Vol 18 (8) ◽  
pp. 1131-1137 ◽  
Author(s):  
Md. Asad Khan ◽  
Md. Zafaryab ◽  
Syed H. Mehdi ◽  
Irfan Ahmad ◽  
Md. Moshahid A. Rizvi
Keyword(s):  
Cervical Cancer ◽  
Cell Line ◽  
Sodium Tripolyphosphate ◽  
Chitosan Nanoparticles ◽  
Physicochemical Characterization ◽  
Cancer Cell Line ◽  
Cervical Cancer Cell Line ◽  
Curcumin Nanoparticles ◽  
Siha Cell Line ◽  
Significant Uptake

Background: Curcumin is a potent anticancer agent and has great potential efficacy against different types of cancers. A major disadvantage of curcumin, however, is its poor solubility and bioavailability. Objective: The aim of the present work is to synthesize chitosan and curcumin-loaded chitosan nanoparticles and their characterization through various physicochemical methods and cellular uptake in cervical cancer cell line SiHa. Method: Chitosan nanoparticles were synthesized through the method of ionic gelation of chitosan with sodium Tripolyphosphate (TPP). In addition, the internal structure of chitosan nanoparticles and curcumin loaded chitosan nanoparticles were characterized by DLS, UV-Visible spectrophotometer, DSC, LCMS and LDH assay. Results: The studies presented demonstrate that curcumin-loaded chitosan nanoparticles showed increased uptake in the SiHa cells as compared to free curcumin and chitosan nanoparticles did not show any significant uptake in SiHa cell line. The curcumin-loaded chitosan nanoparticles released more lactate and lower ATP as compared to native curcumin in cervical cancer lines such as SiHa, CaSki and HeLa. Conclusion: Thus, chitosan based curcumin nanoparticles could be used as a potent vector / delivery agent for drug targeting in the treatment of cervical cancer.

Curcumin causes promoter hypomethylation and increased expression of FANCF gene in SiHa cell line

2012 ◽  
Vol 365 (1-2) ◽  
pp. 29-35 ◽  
Author(s):  
Gaurav Parashar ◽  
Nidarshana Chaturvedi Parashar ◽  
Neena Capalash
Keyword(s):  
Cell Line ◽  
Siha Cell ◽  
Siha Cell Line

TGFβ1-mediated epithelial to mesenchymal transition is accompanied by invasion in the SiHa cell line

2002 ◽  
Vol 81 (8) ◽  
pp. 457-468 ◽  
Author(s):  
Jae Youn Yi ◽  
Kyu Chung Hur ◽  
EunAh Lee ◽  
Yong Jae Jin ◽  
Carlos L. Arteaga ◽  
...  
Keyword(s):  
Cell Line ◽  
Epithelial To Mesenchymal Transition ◽  
Siha Cell ◽  
Mesenchymal Transition ◽  
Siha Cell Line

scholarly journals Differences in the Expression of Human Papillomavirus Type 16 (HPV-16) E6 Oncogene mRNA in SiHa Cell Line Inoculated with CMV, HSV or Ureaplasmas

2014 ◽  
Vol 62 (1) ◽  
pp. 70-75 ◽  
Author(s):  
Sława Szostek ◽  
Barbara Zawilińska ◽  
Małgorzata Biernat-Sudolska ◽  
Jolanta Kopeć ◽  
Ewa Kleszcz ◽  
...  
Keyword(s):  
Human Papillomavirus ◽  
Cell Line ◽  
Siha Cell ◽  
Hpv 16 ◽  
Human Papillomavirus Type 16 ◽  
Siha Cell Line
Sign in / Sign up

Export Citation Format

Share Document