An overview of the reproductive system in mucopolysaccharidosis and case control study to identify menstrual and pregnancy complications in women with MPS

2020 ◽  
Vol 129 (2) ◽  
pp. S127-S128
Author(s):  
Merlene Peter ◽  
Stephanie Cagle
Keyword(s):  
Reproductive System ◽  
Pregnancy Complications ◽  
Case Control Study ◽  
Case Control ◽  
Control Study

Maternal-Fetal Management in Trombophilia Related and Placenta-Mediated Pregnancy Complications

2018 ◽  
Vol 69 (9) ◽  
pp. 2396-2401
Author(s):  
Costin Berceanu ◽  
Elena Loredana Ciurea ◽  
Monica Mihaela Cirstoiu ◽  
Sabina Berceanu ◽  
Anca Maria Ofiteru ◽  
...  
Keyword(s):  
Pregnant Women ◽  
Pregnancy Complications ◽  
Case Control Study ◽  
Case Control ◽  
Placental Insufficiency ◽  
Management Options ◽  
Specific Therapy ◽  
Pregnancy Morbidity ◽  
The Impact ◽  
Control Study

It is widely accepted that thrombophilia in pregnancy greatly increases the risk of venous thromboembolism. Pregnancy complications arise, at least partly, from placental insufficiency. Any change in the functioning of the gestational transient biological system, such as inherited or acquired thrombophilia, might lead to placental insufficiency. In this research we included 64 pregnant women with trombophilia and 70 cases non-trombophilic pregnant women, with or without PMPC, over a two-year period. The purpose of this multicenter case-control study is to analyze the maternal-fetal management options in obstetric thrombophilia, the impact of this pathology on the placental structure and possible correlations with placenta-mediated pregnancy complications. Maternal-fetal management in obstetric thrombophilia means preconceptional or early diagnosis, prevention of pregnancy morbidity, specific therapy as quickly as possible and fetal systematic surveilance to identify the possible occurrence of placenta-mediated pregnancy complications.

Are Anti-β2 Glycoprotein 1 Antibodies Associated with Placenta-Mediated Pregnancy Complications? A Nested Case–Control Study

2018 ◽  
Vol 35 (11) ◽  
pp. 1093-1099 ◽  
Author(s):  
Leslie Skeith ◽  
Karim Abou-Nassar ◽  
Mark Walker ◽  
Tim Ramsay ◽  
Ronald Booth ◽  
...  
Keyword(s):  
Pregnant Women ◽  
Pregnancy Complications ◽  
Case Control Study ◽  
Late Pregnancy ◽  
Case Control ◽  
Immunoglobulin M ◽  
Enzyme Linked Immunosorbent Assay ◽  
Significant Difference ◽  
Antibody Positivity ◽  
Control Study

Background While anti-β2 glycoprotein 1 (anti-β2GP1) antibody positivity is included in the diagnostic criteria for antiphospholipid syndrome (APS), the association between anti-β2GP1 and the obstetrical complications of APS has been inconsistently reported and remains unclear. Objective We completed a case–control study nested within the Canadian Ottawa and Kingston (OaK) Birth Cohort to evaluate the association between anti-β2GP1 antibody positivity and placenta-mediated pregnancy complications. Study Design Five hundred cases were randomly selected among pregnant women who experienced any of the following independently adjudicated placenta-mediated pregnancy complications: preeclampsia, placental abruption, late pregnancy loss (≥ 12 weeks' gestation), and birth of a small-for-gestational age (SGA) infant < 10th percentile. Five hundred pregnant women without any placenta-mediated pregnancy complications were selected as controls. Stored blood samples were analyzed for the presence of anti-β2GP1 antibodies by enzyme-linked immunosorbent assay. Results Anti-β2GP1 immunoglobulin G (IgG) and/or immunoglobulin M (IgM) antibodies in titers ≥ 20 G/M units (> 99th percentile) were present in 24 of 497 (4.8%) of controls and 33 of 503 (6.6%) of cases. There was no significant difference between cases and controls for the composite outcome of any placenta-mediated pregnancy complications (odds ratio, 1.38, 95% confidence interval [CI], 0.8–2.37, p = 0.25). Conclusion Our results call into question the association between anti-β2GP1 antibodies and placenta-mediated pregnancy complications, with further research needed.

Pregnancy complications in the mothers who delivered boys with isolated hypospadias – a population-based case–control study

2014 ◽  
Vol 28 (4) ◽  
pp. 489-493 ◽  
Author(s):  
Stelios Mavrogenis ◽  
Róbert Urban ◽  
Andrew E. Czeizel
Keyword(s):  
Pregnancy Complications ◽  
Case Control Study ◽  
Population Based ◽  
Case Control ◽  
Control Study

scholarly journals Hyperthyroidism as a Potential Risk Factor for Placental Abruption: A Case Control Study

2021 ◽  
Author(s):  
Tomomi Kotani ◽  
Kenji Imai ◽  
Takafumi Ushida ◽  
Yoshinori Moriyama ◽  
Tomoko Kobayashi ◽  
...  
Keyword(s):  
Pregnancy Outcomes ◽  
Pregnancy Complications ◽  
Case Control Study ◽  
Placental Abruption ◽  
Case Control ◽  
University Hospital ◽  
Control Group ◽  
Multivariable Logistic Regression Analysis ◽  
Increased Risk ◽  
Control Study

Abstract BackgroundOvert hyperthyroidism and hypothyroidism are associated with pregnancy complications; however, most women with these conditions are diagnosed before conception and are under treatment during pregnancy, especially in the developed countries. The purpose of this study was to investigate pregnancy complications among these women.MethodsA retrospective case-control study was conducted, and data on 3824 pregnant women who gave birth at Nagoya University Hospital located in Japan from 2005 to 2014 was collected. The pregnancy outcomes were divided and compared among three groups: the control group (n = 3709), the hyperthyroidism group (n = 52) and the hypothyroidism group (n = 63). Risk factors for placental abruption were also evaluated in singleton pregnancies (n = 3588) by multivariable logistic regression analysis. Moreover, in hyperthyroidism, thyroid function was also compared between successful and failed placentation group, and the latter group included placental abruption and preeclampsia. ResultsThe incidence of placental abruption was significantly higher in hyperthyroidism than in control and hypothyroidism groups (p < 0.01). Hyperthyroidism was independently associated with an increased risk of placental abruption (adjusted odds ratio = 12.52, 95% confidence interval = 2.91–53.88). Thyroid stimulating hormone (TSH) was significantly lower in failed placentation group than in successful placentation group (p < 0.05). ConclusionAccording to the results of our study, pregnancy outcomes in women with treated hypothyroidism were comparable with those in women without thyroid disease. Conversely, women with treated hyperthyroidism showed an independent risk of placental abruption, which might be related with lower TSH level at early gestation. However, further research is required to validate our findings.

scholarly journals Pregnancy complications in acquired thrombotic thrombocytopenic purpura: a case–control study

2014 ◽  
Vol 9 (1) ◽  
Author(s):  
Barbara Ferrari ◽  
Alberto Maino ◽  
Luca A Lotta ◽  
Andrea Artoni ◽  
Silvia Pontiggia ◽  
...  
Keyword(s):  
Thrombotic Thrombocytopenic Purpura ◽  
Pregnancy Complications ◽  
Case Control Study ◽  
Case Control ◽  
Thrombocytopenic Purpura ◽  
Control Study

scholarly journals Increased incidence of pregnancy complications in women who later develop scleroderma: a case control study

2011 ◽  
Vol 13 (6) ◽  
pp. R183 ◽  
Author(s):  
Linda van Wyk ◽  
Jacolien van der Marel ◽  
Annemie JM Schuerwegh ◽  
Anne A Schouffoer ◽  
Alexandre E Voskuyl ◽  
...  
Keyword(s):  
Pregnancy Complications ◽  
Case Control Study ◽  
Case Control ◽  
Control Study

scholarly journals Birth outcomes and pregnancy complications of women with uterine leiomyoma—a population-based case-control study

Health ◽  
2010 ◽  
Vol 02 (06) ◽  
pp. 566-574
Author(s):  
Ferenc Bánhidy ◽  
Nándor ács ◽  
Erzsébet H. Puhó ◽  
Andrew E. Czeizel
Keyword(s):  
Birth Outcomes ◽  
Pregnancy Complications ◽  
Uterine Leiomyoma ◽  
Case Control Study ◽  
Population Based ◽  
Case Control ◽  
Control Study

scholarly journals Hypotension in pregnant women: a population-based case–control study of pregnancy complications and birth outcomes

2010 ◽  
Vol 34 (1) ◽  
pp. 55-61 ◽  
Author(s):  
Ferenc Bánhidy ◽  
Nándor Ács ◽  
Erzsébet H Puhó ◽  
Andrew E Czeizel
Keyword(s):  
Pregnant Women ◽  
Birth Outcomes ◽  
Pregnancy Complications ◽  
Case Control Study ◽  
Population Based ◽  
Case Control ◽  
Control Study
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