scholarly journals Corrigendum to “Comparative analysis of brain pathology in heparan sulphate storing mucopolysaccharidosis” [Molecular Genetics and Metabolism 131 (2020) pages 197–205]

2021 ◽  
Author(s):  
Ainslie Derrick-Roberts ◽  
Xenia Kaidonis ◽  
Matilda R. Jackson ◽  
Wan Chin Liaw ◽  
XiaoDan Ding ◽  
...  
Keyword(s):  
Comparative Analysis ◽  
Molecular Genetics ◽  
Heparan Sulphate ◽  
Brain Pathology

Comparative analysis of brain pathology in heparan sulphate storing mucopolysaccharidoses

2020 ◽  
Vol 131 (1-2) ◽  
pp. 197-205
Author(s):  
Ainslie Derrick-Roberts ◽  
Xenia Kaidonis ◽  
Matilda R. Jackson ◽  
Wan Chin Liaw ◽  
XiaoDan Ding ◽  
...  
Keyword(s):  
Comparative Analysis ◽  
Heparan Sulphate ◽  
Brain Pathology

scholarly journals Chronic Cerebral Ischaemia Forms New Cholinergic Mechanisms of Learning and Memory

2010 ◽  
Vol 2010 ◽  
pp. 1-17 ◽  
Author(s):  
E. I. Zakharova ◽  
Z. I. Storozheva ◽  
A. M. Dudchenko ◽  
A. A. Kubatiev
Keyword(s):  
Comparative Analysis ◽  
Learning And Memory ◽  
Water Maze ◽  
Brain Structures ◽  
Molecular Profile ◽  
Brain Pathology ◽  
Synaptic Organization ◽  
Cholinergic Mechanisms ◽  
The Individual ◽  
The Brain

The purpose of this research was a comparative analysis of cholinergic synaptic organization following learning and memory in normal and chronic cerebral ischaemic rats in the Morris water maze model. Choline acetyltransferase and protein content were determined in subpopulations of presynapses of “light” and “heavy” synaptosomal fractions of the cortex and the hippocampus, and the cholinergic projective and intrinsic systems of the brain structures were taken into consideration. We found a strong involvement of cholinergic systems, both projective and intrinsic, in all forms of cognition. Each form of cognition had an individual cholinergic molecular profile and the cholinergic synaptic compositions in the ischaemic rat brains differed significantly from normal ones. Our data demonstrated that under ischaemic conditions, instead of damaged connections new key synaptic relationships, which were stable against pathological influences and able to restore damaged cognitive functions, arose. The plasticity of neurochemical links in the individual organization of certain types of cognition gave a new input into brain pathology and can be used in the future for alternative corrections of vascular and other degenerative dementias.

Introduction

1978 ◽  
Vol 36 (3) ◽  
pp. 543-544
Author(s):  
W. Bernard
Keyword(s):  
Molecular Weight ◽  
Electron Microscope ◽  
Nucleic Acid ◽  
Gene Mapping ◽  
Molecular Genetics ◽  
Cell Biology ◽  
Gene Activity ◽  
Close Connection ◽  
Basic Information ◽  
Simple Systems

In comparison to many other fields of ultrastructural research in Cell Biology, the successful exploration of genes and gene activity with the electron microscope in higher organisms is a late conquest. Nucleic acid molecules of Prokaryotes could be successfully visualized already since the early sixties, thanks to the Kleinschmidt spreading technique - and much basic information was obtained concerning the shape, length, molecular weight of viral, mitochondrial and chloroplast nucleic acid. Later, additonal methods revealed denaturation profiles, distinction between single and double strandedness and the use of heteroduplexes-led to gene mapping of relatively simple systems carried out in close connection with other methods of molecular genetics.

New insights into heparan sulphate biosynthesis from the study of mutant mice

2002 ◽  
Vol 69 ◽  
pp. 47-57 ◽  
Author(s):  
Catherine L. R. Merry ◽  
John T. Gallagher
Keyword(s):  
Growth Factors ◽  
Biosynthetic Pathway ◽  
Heparan Sulphate ◽  
Mutant Mice ◽  
Gene Products ◽  
Multiple Gene ◽  
Adhesion Proteins ◽  
Ligand Interactions

Heparan sulphate (HS) is an essential co-receptor for a number of growth factors, morphogens and adhesion proteins. The biosynthetic modifications involved in the generation of a mature HS chain may determine the strength and outcome of HS–ligand interactions. These modifications are catalysed by a complex family of enzymes, some of which occur as multiple gene products. Various mutant mice have now been generated, which lack the function of isolated components of the HS biosynthetic pathway. In this discussion, we outline the key findings of these studies, and use them to put into context our own work concerning the structure of the HS generated by the Hs2st-/- mice.

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