A 10-step framework for use of read-across (RAX) in next generation risk assessment (NGRA) for cosmetics safety assessment

2022 ◽  
pp. 105094
Author(s):  
Camilla Alexander-White ◽  
Dagmar Bury ◽  
Mark Cronin ◽  
Matthew Dent ◽  
Eric Hack ◽  
...  
Keyword(s):  
Risk Assessment ◽  
Safety Assessment ◽  
Next Generation

SEISMIC RISK ASSESSMENT AND REDUCTION IN ITALY

2019 ◽  
Vol 1 (Special Issue on First SACEE'19) ◽  
pp. 55-75
Author(s):  
Fabio Sabetta
Keyword(s):  
Risk Assessment ◽  
Seismic Risk ◽  
Safety Assessment ◽  
Public Funding ◽  
Tax Incentives ◽  
Technical Training ◽  
Disaster Prevention ◽  
Existing Buildings ◽  
Seismic Risk Assessment ◽  
Post Disaster

In this paper, the main features of the policies adopted in Italy for seismic risk reduction are discussed. Particular attention is given to the Pre-disaster prevention activities such as the implementation of the building code, the seismic risk assessment for a priority scale of intervention, tax incentives and public funding for the vulnerability reduction of the existing buildings, information to population and school education, technical training of experts. The phases of response and post-disaster activities, including emergency management, search and rescue, loss scenarios, and safety assessment of buildings, are also discussed taking example from the most recent devastating earthquakes in Italy (L.Aquila 2009, Amatrice 2016).

Amended Safety Assessment of Methylchloroisothiazolinone and Methylisothiazolinone as Used in Cosmetics

2021 ◽  
Vol 40 (1_suppl) ◽  
pp. 20S-33S
Author(s):  
Christina L. Burnett ◽  
Wilma F. Bergfeld ◽  
Donald V. Belsito ◽  
Curtis D. Klaassen ◽  
Daniel C. Liebler ◽  
...  
Keyword(s):  
Risk Assessment ◽  
Safety Assessment ◽  
Expert Panel ◽  
Quantitative Risk Assessment ◽  
Cosmetic Products ◽  
Human Data

The Expert Panel for Cosmetic Ingredient Safety (Panel) reassessed the safety of the mixture Methylchloroisothiazolinone (MCI)/Methylisothiazolinone (MI), which functions as a preservative in cosmetic products. The Panel reviewed relevant animal and human data provided in this safety assessment, and data from the previously published safety assessment of this mixture, and concluded that MCI/MI is safe in cosmetics when formulated to be nonsensitizing, based on the results of a quantitative risk assessment or similar methodology; however, at no point should concentrations exceed 7.5 ppm in leave-on products or 15 ppm in rinse-off products.

Cost effectiveness analysis of a next generation risk assessment score for cardiovascular disease

2013 ◽  
Vol 17 (2) ◽  
pp. 132-141
Author(s):  
Evangelos Hytopoulos ◽  
Martin L. Lee ◽  
Michael Beggs ◽  
Cynthia French ◽  
Kuo Bianchini Tong
Keyword(s):  
Cardiovascular Disease ◽  
Risk Assessment ◽  
Cost Effectiveness ◽  
Cost Effectiveness Analysis ◽  
Next Generation ◽  
Assessment Score ◽  
Effectiveness Analysis

Challenges and Developments in Navigational Risk Assessment With Large Uncertainty

2014 ◽  
Author(s):  
Xinping Yan ◽  
Jinfen Zhang ◽  
Di Zhang ◽  
Carlos Guedes Soares
Keyword(s):  
Risk Assessment ◽  
Safety Assessment ◽  
Oil Spills ◽  
Rule Base ◽  
Event Tree ◽  
Event Tree Analysis ◽  
General Application ◽  
The Past ◽  
Formal Safety Assessment ◽  
Belief Rule Base

Concerns have been raised to navigational safety worldwide because of the increasing throughput and the passing ships during the past decades while maritime accidents such as collisions, groundings, overturns, oil-spills and fires have occurred, causing serious consequences. Formal Safety Assessment (FSA) has been acknowledged to be a framework widely used in maritime risk assessment. Under this framework, this paper discusses certain existing challenges when an effective safety assessment is carried out under a variety of uncertainties. Some theories and methodologies are proposed to overcome the present challenges, e.g., Fault/Event Tree Analysis (FTA/ETA), Evidential Reasoning (ER), Bayesian Belief Network (BBN) and Belief Rule Base (BRB). Subsequently, three typical case studies that have been carried out in the Yangtze River are introduced to illustrate the general application of those approaches. These examples aim to demonstrate how advanced methodologies can facilitate navigational risk assessment under high uncertainties.

Next generation risk assessment for skin sensitization combining non-animal data and read-across:

2021 ◽  
Vol 350 ◽  
pp. S65
Author(s):  
F. Gautier ◽  
F. Tourneix ◽  
H. Assaf Vandecasteele ◽  
D Bury ◽  
N. Alépée
Keyword(s):  
Risk Assessment ◽  
Skin Sensitization ◽  
Next Generation ◽  
Animal Data

Next Generation Risk Assessment of Chemicals

10.33540/261 ◽  
2021 ◽  
Author(s):  
◽  
Emma Eltje Jacoba Kasteel
Keyword(s):  
Risk Assessment ◽  
Next Generation

scholarly journals A Next-Generation Risk Assessment Case Study for Coumarin in Cosmetic Products

2020 ◽  
Vol 176 (1) ◽  
pp. 236-252 ◽  
Author(s):  
Maria T Baltazar ◽  
Sophie Cable ◽  
Paul L Carmichael ◽  
Richard Cubberley ◽  
Tom Cull ◽  
...  
Keyword(s):  
Risk Assessment ◽  
Biological Effects ◽  
In Vitro Assays ◽  
Next Generation ◽  
Animal Testing ◽  
Immunomodulatory Effects ◽  
Margin Of Safety

Abstract Next-Generation Risk Assessment is defined as an exposure-led, hypothesis-driven risk assessment approach that integrates new approach methodologies (NAMs) to assure safety without the use of animal testing. These principles were applied to a hypothetical safety assessment of 0.1% coumarin in face cream and body lotion. For the purpose of evaluating the use of NAMs, existing animal and human data on coumarin were excluded. Internal concentrations (plasma Cmax) were estimated using a physiologically based kinetic model for dermally applied coumarin. Systemic toxicity was assessed using a battery of in vitro NAMs to identify points of departure (PoDs) for a variety of biological effects such as receptor-mediated and immunomodulatory effects (Eurofins SafetyScreen44 and BioMap Diversity 8 Panel, respectively), and general bioactivity (ToxCast data, an in vitro cell stress panel and high-throughput transcriptomics). In addition, in silico alerts for genotoxicity were followed up with the ToxTracker tool. The PoDs from the in vitro assays were plotted against the calculated in vivo exposure to calculate a margin of safety with associated uncertainty. The predicted Cmax values for face cream and body lotion were lower than all PoDs with margin of safety higher than 100. Furthermore, coumarin was not genotoxic, did not bind to any of the 44 receptors tested and did not show any immunomodulatory effects at consumer-relevant exposures. In conclusion, this case study demonstrated the value of integrating exposure science, computational modeling and in vitro bioactivity data, to reach a safety decision without animal data.

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