Role of late potentials in identifying patients at risk for ventricular tachycardia after surgical correction of congenital heart disease

Sudden death occurs in patients after repair of congenital heart disease. In those with tetralogy of Fallot, or a similar lesion, ventricular tachycardia has been hypothesized as the major arrhythmic mechanism for sudden death. It would be desirable to identify individuals at risk for sudden death, to determine which arrhythmia would be likely to cause sudden death, and to treat those individuals with an appropriate antiarrhythmic to prevent sudden death. For the last 10 years, physicians have been treating patients with antiarrhythmic drugs, based on a number of criteria, the most common of which is the presence of premature ventricular contractions.1,2 The practice has recently been called into question by the CAST trial. It is the purpose of this paper to review the evidence that repair causes ventricular arrhythmias, that ventricular arrhythmias cause sudden death, and that ventricular arrhythmias should be treated prophylactically.

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Role of ventricular late potentials for identification of patients at risk of ventricular tachycardia

Developments in Cardiovascular Medicine - Ventricular Tachycardias ◽

10.1007/978-94-009-3323-1_19 ◽

1987 ◽

pp. 256-270

Author(s):

Günter Breithardt ◽

Martin Borggrefe ◽

Klaus Haerten ◽

Joachim Schwarzmaier ◽

Ulrich Karbenn ◽

...

Keyword(s):

At Risk ◽

Ventricular Tachycardia ◽

Late Potentials ◽

Ventricular Late Potentials ◽

Patients At Risk

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Late potentials and inducible ventricular tachycardia in surgically repaired congenital heart disease.

Circulation ◽

10.1161/01.cir.82.5.1690 ◽

1990 ◽

Vol 82 (5) ◽

pp. 1690-1696 ◽

Cited By ~ 34

Author(s):

J A Stelling ◽

D A Danford ◽

J D Kugler ◽

J R Windle ◽

J P Cheatham ◽

...

Keyword(s):

Congenital Heart Disease ◽

Heart Disease ◽

Ventricular Tachycardia ◽

Congenital Heart ◽

Late Potentials

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The Prognostic Role of the Right Ventricle in Patients With Heart Failure or Congenital Heart Disease

Case Medical Research ◽

10.31525/ct1-nct03969394 ◽

2019 ◽

Author(s):

Keyword(s):

Heart Failure ◽

Congenital Heart Disease ◽

Heart Disease ◽

Right Ventricle ◽

Congenital Heart ◽

Prognostic Role ◽

Patients With Heart Failure ◽

The Right

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The microbiome’s relationship with congenital heart disease: more than a gut feeling

Journal of Congenital Cardiology ◽

10.1186/s40949-021-00060-4 ◽

2021 ◽

Vol 5 (1) ◽

Author(s):

Dan Feng ◽

Jason T. Christensen ◽

Anji T. Yetman ◽

Merry L. Lindsey ◽

Amar B. Singh ◽

...

Keyword(s):

Congenital Heart Disease ◽

Heart Disease ◽

Patient Population ◽

Congenital Heart ◽

Basic Research ◽

Intestinal Epithelial ◽

Barrier Dysfunction ◽

Intestinal Dysbiosis ◽

Epithelial Barrier Dysfunction

AbstractPatients with congenital heart disease (CHD) are at risk for developing intestinal dysbiosis and intestinal epithelial barrier dysfunction due to abnormal gut perfusion or hypoxemia in the context of low cardiac output or cyanosis. Intestinal dysbiosis may contribute to systemic inflammation thereby worsening clinical outcomes in this patient population. Despite significant advances in the management and survival of patients with CHD, morbidity remains significant and questions have arisen as to the role of the microbiome in the inflammatory process. Intestinal dysbiosis and barrier dysfunction experienced in this patient population are increasingly implicated in critical illness. This review highlights possible CHD-microbiome interactions, illustrates underlying signaling mechanisms, and discusses future directions and therapeutic translation of the basic research.

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