Bone Mass, Vitamin D Deficiency, and Hyperparathyroidism in Congestive Heart Failurefn1fn1This work was supported in part by Grants AR-41391 and RR-006645 from the National Institutes of Health.

Abstract Backround Osteogenesis imperfecta(OI) is a frequent bone fragility disorder in children. The purpose of this study was to assess the BMD and Vitamin D level in children with OI in southern Iran. Method This case-control study was conducted on 23 children, clinically diagnosed as osteogenesis imperfecta and 23 age- and gender-matched healthy controls. Demographic and anthropometric data, biochemical parameters, puberty, sun exposure and physical activity were assessed. Bone mineral density (BMD) was measured by Dual-energy X-ray absorptiometry (DXA). Data analysis was done by SPSS22. Results Forty-three point four percent of OI patients and fifty-six point five percent of control group had vitamin D deficiency (P = 0.376). Thirteen OI patients (56%) had low bone mass for chronological age in lumbar area (P < 0.001). Fracture episodes during treatment was significantly influenced by time of Pamidronate start, courses of Pamidronate injection, puberty and sun exposure (P values = 0.015, 0.030, 0.044 and 0.032, respectively). Fracture episodes during treatment had significantly increased in patients who had received Pamidronate more than 3 years compared with those received less than 3 years(P values = 0.047). Conclusions This study showed that vitamin D deficiency is prevalent amongst OI children in southern Iran. More than half of the OI children had low bone mass for chronological age in lumbar area, despite receiving bisphosphonate therapy. The present results revealed that early initiation of Pamidronate and number of Pamidronate courses are associated with lower fracture rate. However, treatment period more than 3 years can have adverse effect on fracture rates.

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Subclinical Vitamin D Deficiency in Postmenopausal Women with Low Vertebral Bone Mass*

The Journal of Clinical Endocrinology & Metabolism ◽

10.1210/jcem-72-3-628 ◽

1991 ◽

Vol 72 (3) ◽

pp. 628-634 ◽

Cited By ~ 170

Author(s):

DENNIS T. VILLAREAL ◽

ROBERTO CIVITELLI ◽

ARKADI CHINES ◽

LOUIS V. AVIOLI

Keyword(s):

Vitamin D ◽

Bone Mass ◽

Vitamin D Deficiency ◽

Postmenopausal Women ◽

Vertebral Bone ◽

Subclinical Vitamin ◽

Vertebral Bone Mass

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Vitamin D Status as a Determinant of Peak Bone Mass in Young Finnish Men

The Journal of Clinical Endocrinology & Metabolism ◽

10.1210/jc.2003-030817 ◽

2004 ◽

Vol 89 (1) ◽

pp. 76-80 ◽

Cited By ~ 94

Author(s):

Ville-Valtteri Välimäki ◽

Henrik Alfthan ◽

Eero Lehmuskallio ◽

Eliisa Löyttyniemi ◽

Timo Sahi ◽

...

Keyword(s):

Vitamin D ◽

Lumbar Spine ◽

Bone Mass ◽

Bone Mineral Content ◽

Vitamin D Deficiency ◽

Bone Mineral ◽

Peak Bone Mass ◽

Mineral Content ◽

Young Men ◽

Vitamin D Status

Severe vitamin D deficiency causes rickets, but scarce data are available about the extent to which vitamin D status determines the development of the peak bone mass in young adults. Our aim was to evaluate the prevalence of vitamin D deficiency [serum 25-hydroxyvitamin D (25-OHD) less than the lower limit of the reference range of 20–105 nmol/liter] and the relationship between vitamin D status and peak bone mass among young Finnish men. A cross-sectional study of determinants of peak bone mass with data on lifestyle factors collected retrospectively was performed in 220 young men, aged 18.3–20.6 yr. One hundred and seventy men were recruits of the Finnish Army, and 50 were men of similar age who had postponed their military service for reasons not related to health. Bone mineral content, bone mineral density, and scan area were measured in lumbar spine and upper femur by dual energy x-ray absorptiometry. Serum 25-OHD concentrations were followed prospectively for 1 yr. In July 2000, only 0.9% of the men had vitamin D deficiency, but 6 months later, in the winter, the respective percentage was 38.9%. After adjusting for age, height, weight, exercise, smoking, calcium, and alcohol intake, there existed a positive correlation between serum 25-OHD and bone mineral content at lumbar spine (P = 0.057), femoral neck (P = 0.041), trochanter (P = 0.010), and total hip (P = 0.025). The correlation coefficients for the bone mineral densities at the four measurement sites were 0.035, 0.061, 0.056, and 0.068, respectively. No correlation was found to scan area. We conclude that vitamin D deficiency is very common in Finnish young men in the winter, and it may have detrimental effects on the acquisition of maximal peak bone mass. As in Finland vitamin D supplementation to infants is now stopped at the age of 3 yr, it can be asked whether at our latitude it should be continued from that age onward, not for the prevention of rickets, but as prophylaxis for osteoporosis.

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High prevalence of vitamin D deficiency and reduced bone mass in multiple sclerosis

Neurology ◽

10.1212/wnl.44.9.1687 ◽

1994 ◽

Vol 44 (9) ◽

pp. 1687-1687 ◽

Cited By ~ 207

Author(s):

J. Nieves ◽

F. Cosman ◽

J. Herbert ◽

V. Shen ◽

R. Lindsay

Keyword(s):

Multiple Sclerosis ◽

Vitamin D ◽

Bone Mass ◽

Vitamin D Deficiency ◽

High Prevalence

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Association of vitamin D deficiency and bone mass with liver and heart iron overload in transfusion dependent thalassemia

International Journal of Contemporary Pediatrics ◽

10.18203/2349-3291.ijcp20202613 ◽

2020 ◽

Vol 7 (7) ◽

pp. 1544

Author(s):

Anjali Verma ◽

Alok Khanna ◽

Babita Jangra ◽

Sanjiv Nanda ◽

Surender Verma

Keyword(s):

Vitamin D ◽

Bone Mass ◽

Iron Overload ◽

Vitamin D Deficiency ◽

Mass Density ◽

Iron Concentration ◽

Bone Mass Density ◽

Liver Iron ◽

Vitamin D Levels ◽

Liver Iron Overload

Background: Transfusion dependent thalassemia patients are reported to have Vitamin D insufficiency/deficiency in many countries. Vitamin D hydroxylation occurs in the liver; whether liver iron overload interferes with this step has not been addressed till date. This study helps to establish an association between liver iron concentration (LIC) and heart iron concentration (MIC) with vitamin D levels and Bone Mass Density in these patients.Methods: A cross sectional study was done by including transfusion dependent Thalassemia patients (TM) if they had an assessment of Liver and cardiac iron done by T2*MRI and bone mineral density by DEXA. Clinical data regarding age, gender, type of iron chelation therapy and laboratory data of S. ferritin and Vitamin D was collected. Data was assessed using appropriate statistical methods.Results: Among 40 TM patients were taken and mean age was 17.6 years. Vitamin D deficiency was identified in 26(65%). 20 out of them had an LIC>7mg/g DW and 6 had MIC>1.65mg/g DW. There was a significant association between LIC>7mg/g and vitamin D level<20 ng/ml and a significant inverse correlation between LIC and vitamin D, suggesting that liver iron overload may indeed affect vitamin D metabolism. Osteopenia was present in 32.5% and osteoporosis was present in 27.5 % of all TM patients. Reduced Bone Mass Density was also found to be linked with iron over load.Conclusions: Regular monitoring of vitamin D levels and supplementation is required in patients with severe liver and heart iron load. More studies are needed to confirm these results.

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