Involvement of CD14 on human gingival fibroblasts in Porphyromonas gingivalis lipopolysaccharide-mediated interleukin-6 secretion

1998 ◽  
Vol 43 (9) ◽  
pp. 687-694 ◽  
Author(s):  
Pao-Li Wang ◽  
Katsuaki Sato ◽  
Mari Oido ◽  
Takeo Fujii ◽  
Yusuke Kowashi ◽  
...  
Keyword(s):  
Porphyromonas Gingivalis ◽  
Interleukin 6 ◽  
Human Gingival Fibroblasts ◽  
Gingival Fibroblasts ◽  
Porphyromonas Gingivalis Lipopolysaccharide

scholarly journals Toll-Like Receptors Confer Responsiveness to Lipopolysaccharide from Porphyromonas gingivalis in Human Gingival Fibroblasts

2000 ◽  
Vol 68 (6) ◽  
pp. 3731-3735 ◽  
Author(s):  
Kouich Tabeta ◽  
Kazuhisa Yamazaki ◽  
Sachiko Akashi ◽  
Kensuke Miyake ◽  
Hidefumi Kumada ◽  
...  
Keyword(s):  
Porphyromonas Gingivalis ◽  
Proinflammatory Cytokines ◽  
Interleukin 6 ◽  
Intracellular Signaling ◽  
Myeloid Cells ◽  
Human Gingival Fibroblasts ◽  
Gingival Fibroblasts ◽  
Toll Like Receptors ◽  
Human Homologue ◽  
Periodontopathic Bacteria

ABSTRACT Gingival fibroblasts produce proinflammatory cytokines in response to lipopolysaccharide (LPS) from periodontopathic bacteria. Recently it has become evident that the human homologue of DrosophilaToll can transduce intracellular signaling by LPS stimulation. Toll-like receptors (TLRs) have been identified in myeloid cells; however, their role in nonmyeloid cells such as gingival fibroblasts has not been fully elucidated. Here, we report that human gingival fibroblasts constitutively express TLR2 and TLR4 and that their levels of expression are increased by stimulation with LPS fromPorphyromonas gingivalis. Upregulated expression of interleukin-6 gene and protein in fibroblasts stimulated with LPS is inhibited by anti-TLR4 antibody. These findings suggest that TLRs may confer responsiveness to LPS in gingival fibroblasts.

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