Biological fate of butylated hydroxytoluene (BHT): binding of BHT metabolites to cystine in vitro

1981 ◽  
Vol 30 (8) ◽  
pp. 887-890 ◽  
Author(s):  
Yoshio Nakagawa ◽  
Kogo Hiraga ◽  
Tetsuya Suga
Keyword(s):  
Butylated Hydroxytoluene ◽  
Biological Fate

scholarly journals The Effect of Carnosol, Carnosic Acid and Rosmarinic Acid on the Oxidative Stability of Fat-Filled Milk Powders throughout Accelerated Oxidation Storage

Antioxidants ◽  
2021 ◽  
Vol 10 (5) ◽  
pp. 762
Author(s):  
Katerina Tzima ◽  
Nigel P. Brunton ◽  
Noel A. McCarthy ◽  
Kieran N. Kilcawley ◽  
David T. Mannion ◽  
...  
Keyword(s):  
Rosmarinic Acid ◽  
Solid Phase ◽  
Thiobarbituric Acid ◽  
Butylated Hydroxytoluene ◽  
Carnosic Acid ◽  
Gas Chromatography Mass Spectrometry ◽  
Peroxide Values ◽  
Antioxidant Potency ◽  
Antioxidant Effects

The in vitro antioxidant effects of the most potent antioxidants of rosemary, namely carnosol, carnosic acid and rosmarinic acid (c: ca: ra) were assessed in fat-filled milk powders (FFMPs) under accelerated conditions (40 °C and relative humidity (RH) 23%) over 90 days. Lipid oxidation was assessed in FFMPs by measuring peroxide values (PVs), thiobarbituric acid reactive substances (TBARS) and aroma volatiles using headspace (HS) solid-phase microextraction (SPME) coupled to gas-chromatography-mass spectrometry (GC-MS). The antioxidant potency of c: ca: ra exhibited a concentration-related effect (308 ppm > 200 ppm > 77 ppm), with the highest concentration being the most effective at controlling the formation of TBARS and PVs. At a concentration of 308 ppm c: ca: ra were particularly effective (p < 0.05) in inhibiting all the evaluated oxidation indices (primary and secondary) compared to the control samples, but in some cases less effectively (p < 0.05) than butylated hydroxyanisole: butylated hydroxytoluene (BHA: BHT) (200 ppm).

Biological fate of butylated hydroxytoluene (BHT)-Binding of BHT to nucleic acid in vivo

1980 ◽  
Vol 29 (9) ◽  
pp. 1304-1306 ◽  
Author(s):  
Nakagawa Yoshio ◽  
Hiraga Kogo ◽  
Suga Tetsuya
Keyword(s):  
Nucleic Acid ◽  
Butylated Hydroxytoluene ◽  
Biological Fate

Inhibitory Erects of Selenium, Vitamin A and Butylated Hydroxytoluene on Growth of Human Maxillary Cancer Cells In Vitro

1996 ◽  
Vol 23 (1) ◽  
pp. 91-97 ◽  
Author(s):  
Yuzo Yamamoto ◽  
Isao Inoue ◽  
Tomohiko Takasaki ◽  
Hiroaki Takahashi
Keyword(s):  
Vitamin A ◽  
Cancer Cells ◽  
Butylated Hydroxytoluene ◽  
Maxillary Cancer

scholarly journals Identification of In Vitro Metabolites of Synthetic Phenolic Antioxidants BHT, BHA, and TBHQ by LC-HRMS/MS

2020 ◽  
Vol 21 (24) ◽  
pp. 9525
Author(s):  
Ons Ousji ◽  
Lekha Sleno
Keyword(s):  
Isotope Labeling ◽  
Butylated Hydroxytoluene ◽  
Phenolic Antioxidants ◽  
Fragmentation Behavior ◽  
Accurate Mass Measurements ◽  
Oxidative Metabolites ◽  
Biotransformation Products ◽  
Pharmaceutical Industries ◽  
Synthetic Phenolic Antioxidants

Butylated hydroxytoluene (BHT) and its analogs, butylated hydroxyanisole (BHA) and tert-butyl-hydroquinone (TBHQ), are widely used synthetic preservatives to inhibit lipid oxidation in the food, cosmetic and pharmaceutical industries. Despite their widespread use, little is known about their human exposure and related biotransformation products. The metabolism of these compounds was investigated using in vitro incubations with human and rat liver fractions. Liquid chromatography coupled to high-resolution tandem mass spectrometry was employed to detect and characterize stable and reactive species formed via oxidative metabolism, as well as phase II conjugates. Several oxidative metabolites have been detected, as well as glutathione, glucuronide, and sulfate conjugates, many of which were not previously reported. A combination of accurate mass measurements, MS/MS fragmentation behavior, and isotope-labeling studies were used to elucidate metabolite structures.

scholarly journals Phenolic content and antioxidant activity of Phymatopteris hastata

2011 ◽  
Vol 76 (11) ◽  
pp. 1485-1496 ◽  
Author(s):  
Wei Su ◽  
Peiyuan Li ◽  
Lini Huo ◽  
Caiying Wu ◽  
Nana Guo ◽  
...  
Keyword(s):  
Ethyl Acetate ◽  
Ethyl Acetate Extract ◽  
Antioxidant Activities ◽  
Petroleum Ether Extract ◽  
Radical Scavenging ◽  
Reducing Power ◽  
Butylated Hydroxytoluene ◽  
Total Phenolic ◽  
Alcohol Extract

Various solvent extracts of Phymatopteris hastata, a traditional Chinese medicinal material, were screened for their antioxidant activities. Four systems of in vitro testing were employed to investigate the antiradical and antioxidant effect, i.e., the 2,2-diphenyl-1-picryhydrazyl (DPPH) and 2,2'-azino-bis-(3-ethylbenzothiazoline-6-sulfonic acid) (ABTS) systems, the hydroxyl radical scavenging assay and the reducing power. In addition, butylated hydroxytoluene (BHT), a widely used synthetic antioxidant, was also studied for comparison. The results revealed that the ethyl acetate extract exhibited outstanding antioxidant activities, which was close or even superior to BHT. Furthermore, the total phenolic (TP) and total flavonoid (TF) contents of different extracts were measured, expressed as gallic acid and rutin equivalent, respectively. The antioxidant activities and the TP/TF content of different extracts followed the same order: ethyl acetate extract > butyl alcohol extract > petroleum ether extract, showing a good correlation between the antioxidant activities and the TP/TF content. The results showed that these extracts, especially the ethyl acetate extract, were rich in phenolics and flavonoids and could be considered as natural antioxidants.

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