Single-nucleotide polymorphisms in the lipoprotein lipase gene associated with coronary heart disease in Chinese

2002 ◽  
Vol 454 (1) ◽  
pp. 9-18 ◽  
Author(s):  
Zhi G Su ◽  
Si Z Zhang ◽  
Yi P Hou ◽  
T Li ◽  
Daniel W Nebert ◽  
...  
Keyword(s):  
Coronary Heart Disease ◽  
Heart Disease ◽  
Single Nucleotide Polymorphisms ◽  
Lipoprotein Lipase ◽  
Nucleotide Polymorphisms ◽  
Lipase Gene ◽  
Single Nucleotide ◽  
Lipoprotein Lipase Gene

F085 Relations between lipoprotein lipase gene polymorphisms and insulin resistance in patiens with coronary heart disease

1998 ◽  
Vol 136 ◽  
pp. S67
Author(s):  
Wayne H.-H. Sheu ◽  
W.-J. Lee ◽  
C.-Y. Jeng ◽  
Mason H. Young ◽  
Y.-A. Ding ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
Coronary Heart Disease ◽  
Heart Disease ◽  
Lipoprotein Lipase ◽  
Gene Polymorphisms ◽  
Lipase Gene ◽  
Lipoprotein Lipase Gene

1.W05.3 Common mutations in the lipoprotein lipase gene influence plasma lipids and prevalence of coronary heart disease

1997 ◽  
Vol 134 (1-2) ◽  
pp. 12
Author(s):  
M.R. Hayden ◽  
S.E. Gagné ◽  
M.G. Larson ◽  
M.E. Wittekoek ◽  
S.N. Pimstone ◽  
...  
Keyword(s):  
Coronary Heart Disease ◽  
Heart Disease ◽  
Lipoprotein Lipase ◽  
Plasma Lipids ◽  
Lipase Gene ◽  
Lipoprotein Lipase Gene

scholarly journals Chromosome 9p21.3 is Associated with Early-Onset Coronary Heart Disease in the Irish Population

2008 ◽  
Vol 25 (2) ◽  
pp. 81-85 ◽  
Author(s):  
Weihua Meng ◽  
Anne E. Hughes ◽  
Chris C. Patterson ◽  
Christine Belton ◽  
Frank Kee ◽  
...  
Keyword(s):  
Coronary Heart Disease ◽  
Heart Disease ◽  
Single Nucleotide Polymorphisms ◽  
Cause Of Death ◽  
Early Onset ◽  
Nucleotide Polymorphisms ◽  
Irish Population ◽  
Single Nucleotide ◽  
The World ◽  
Family Based

Coronary heart disease (CHD) remains a leading cause of death across the world. A region on chromosome 9p21.3 has been recently reported to be associated with CHD. We evaluated 3 SNPs and 3 common haplotypes in the 9p21.3 region in 1494 individuals from 580 Irish families, where at least 1 member had early-onset (males ≤55yr, females ≤60yr) CHD. Genotypes were determined by multiplex SNaPshot technology. Using the combined TDT/S-TDT test, the 3 single nucleotide polymorphisms (SNP), rs10757274, rs2383206 and rs1333049, were strongly associated with early-onset CHD (p= 2.7 × 10-6, 2.7 × 10-6, 3.8 × 10-7, respectively). Analysis of haplotypes by the TRANSMIT program also showed that the GGC haplotype was associated with early-onset CHD (p= 7.9 × 10-7). In conclusion, using a family-based approach in the Irish population, we have confirmed previous reports of association between a region on chromosome 9p21.3 and early-onset CHD.

Sign in / Sign up

Export Citation Format

Share Document