P-002 Disturbances in the late luteal—early follicular phase transition in infertile women of advanced reproductive age

1997 ◽  
Vol 68 ◽  
pp. S93
Author(s):  
R Buyalos ◽  
S Daneshmond ◽  
P Brzechffa
Keyword(s):  
Phase Transition ◽  
Follicular Phase ◽  
Reproductive Age ◽  
Infertile Women ◽  
Advanced Reproductive Age ◽  
Early Follicular Phase

Prenatal diethylstilbestrol exposure and reproductive hormones in premenopausal women

2015 ◽  
Vol 6 (3) ◽  
pp. 208-216 ◽  
Author(s):  
L. A. Wise ◽  
R. Troisi ◽  
E. E. Hatch ◽  
L. J. Titus ◽  
K. J. Rothman ◽  
...  
Keyword(s):  
Repeated Measures ◽  
Premenopausal Women ◽  
Reproductive Hormones ◽  
Follicular Phase ◽  
Inhibin B ◽  
Reproductive Age ◽  
Endogenous Hormones ◽  
Reproductive Disorders ◽  
Early Follicular Phase

Diethylstilbestrol (DES), a synthetic estrogen widely prescribed to pregnant women in the mid-1900s, is a potent endocrine disruptor. Prenatal DES exposure has been associated with reproductive disorders in women, but little is known about its effects on endogenous hormones. We assessed the association between prenatal DES exposure and reproductive hormones among participants from the Harvard Study of Moods and Cycles (HSMC), a longitudinal study of premenopausal women aged 36–45 years from Massachusetts (1995–1999). Prenatal DES exposure was reported at baseline (43 DES exposed and 782 unexposed). Early follicular-phase concentrations of follicle-stimulating hormone (FSH), luteinizing hormone (LH) and estradiol were measured at baseline and every 6 months during 36 months of follow-up. Inhibin B concentrations were measured through 18 months. We used multivariable logistic and repeated-measures linear regression to estimate odds ratios (OR) and percent differences in mean hormone values (β), respectively, comparing DES exposed with unexposed women, adjusted for potential confounders. DES-exposed women had lower mean concentrations of estradiol (pg/ml) (β=−15.6%, 95% confidence interval (CI): −26.5%, −3.2%) and inhibin B (pg/ml) (β=−20.3%, CI: −35.1%, −2.3%), and higher mean concentrations of FSH (IU/I) (β=12.2%, CI: −1.5%, 27.9%) and LH (IU/I) (β=10.4%, CI: −7.2%, 31.3%), than unexposed women. ORs for the association of DES with maximum FSH>10 IU/I and minimum inhibin B<45 pg/ml – indicators of low ovarian reserve – were 1.90 (CI: 0.86, 4.22) and 4.00 (CI: 0.88–18.1), respectively. Prenatal DES exposure was associated with variation in concentrations of FSH, estradiol and inhibin B among women of late reproductive age.

scholarly journals P-087. Age, cigarette smoking and early follicular phase FSH concentrations in infertile women

1997 ◽  
Vol 12 (Suppl_2) ◽  
pp. 161-162
Author(s):  
A. El-Nemr ◽  
L. Sabatini ◽  
C. Wilson ◽  
A. Lower ◽  
T. Al-Shawaf ◽  
...  
Keyword(s):  
Cigarette Smoking ◽  
Follicular Phase ◽  
Infertile Women ◽  
Early Follicular Phase

The Role of Transient Hyperprolactinaemia in the Short Luteal Phase

1980 ◽  
Vol 25 (4) ◽  
pp. S75-S81
Author(s):  
J. R. T. Coutts ◽  
R. Fleming ◽  
M. C. Macnaughton
Keyword(s):  
Luteal Phase ◽  
Follicular Phase ◽  
Cycle Period ◽  
Plasma Analysis ◽  
Steroid Secretion ◽  
Menstrual Cycles ◽  
Infertile Women ◽  
Late Luteal Phase ◽  
Early Follicular Phase

Daily plasma analysis of complete menstrual cycles from infertile women (n = 32) revealed transient hyperprolactinaemia in a significant number in comparison with normally cycling women. The prolactin elevations occurred for variable durations at different stages of the cycle. Transient hyperprolactinaemia occurring at mid-cycle was associated with reduced late luteal phase steroid levels and short luteal phases. When the prolactin elevations occurred at other times they were unrelated to ovarian steroid levels. Treatment of patients with short luteal phases with bromocriptine (2.5 mg/day) normalised prolactin levels but also reduced gonadotrophins. The net result of these changes was a normalisation of the length of the luteal phase which was now deficient in steroid secretion. To alleviate these problems the treatments proposed for the short luteal phase are either bromocriptine (2.5 mg/day) for 7 days over the mid-cycle period only or bromocriptine for 7 days at mid-cycle in conjunction with a follicular stimulant in the early follicular phase.

scholarly journals ASSESSMENT OF CERVICAL CYTOMORPHOLOGICAL CHANGES IN INFERTILE WOMEN

2021 ◽  
Vol 5 (8) ◽  
Author(s):  
Mamta Choudhary ◽  
Dharmpal Godara
Keyword(s):  
Prospective Study ◽  
Pap Smear ◽  
Follicular Phase ◽  
Reproductive Age ◽  
Age Group ◽  
Women Of Reproductive Age ◽  
Infertile Women ◽  
Cytological Abnormalities ◽  
Infertile Patients ◽  
Reproductive Age Group

Background: Assessment of cervical cytomorphological changes in infertile women.  Methods: The hospital based prospective study was conducted on 50 women of reproductive age group who were in the follicular phase of their cycle and had primary and secondary infertility Results: On pap smear 80.00% patients were present NILM, 12.00% patients were present ASC-US, 4.00% patients were present inflammatory and 2.00% patients were present HSIL & LSIL. Conclusion: We observed that infertile patients, may benefit from cervical cytological screening as they show a higher tendency for cervical cytological abnormalities. Keywords: ASC-US, HSIL, LSIL.

Manipulation of inhibin during the luteal-follicular phase transition of the primate menstrual cycle fails to affect FSH secretion

1994 ◽  
Vol 142 (1) ◽  
pp. 181-186 ◽  
Author(s):  
H M Fraser ◽  
C G Tsonis
Keyword(s):  
Phase Transition ◽  
Menstrual Cycle ◽  
Luteal Phase ◽  
Elevated Serum ◽  
Follicular Phase ◽  
Serum Concentrations ◽  
Late Luteal Phase ◽  
Early Follicular Phase ◽  
Negative Feedback Control

Abstract The pattern of inhibin concentrations in blood during the menstrual cycle in primates has suggested an endocrine role of inhibin in the negative feedback control of FSH secretion during the luteal phase. Conversely, the fall in inhibin during the late luteal phase may play a role in the rise in serum FSH during the luteal-follicular phase transition. This hypothesis was examined by determining the effects of manipulation of inhibin on FSH secretion in stumptailed macaques. During the mid-luteal phase the putative inhibin feedback was inhibited by i.v. administration of 20 ml of ovine antiserum to human recombinant inhibin in 4 macaques. FSH secretion was unaffected during the initial 24 h period post-treatment and the timing of the rise in FSH which occurred during the subsequent luteal-follicular phase transition was normal. To determine whether the elevated serum concentrations of FSH observed during the early follicular phase could be reduced by administration of inhibin, 5 cyclic macaques were treated with 200 μg of recombinant human inhibin i.v. Serum FSH concentrations were unaltered. These results suggest that inhibin does not play a major role in modulating FSH secretion during the luteal-follicular phase transition. Journal of Endocrinology (1994) 142, 181–186

Sign in / Sign up

Export Citation Format

Share Document