Onset and disappearance of gastrointestinal symptoms in diabetes: Influence of psychosocial factors, disease duration and glycemic control

2001 ◽  
Vol 120 (5) ◽  
pp. A232-A232
Author(s):  
N TALLEY ◽  
M JONES ◽  
M HOROWITZ
Keyword(s):  
Glycemic Control ◽  
Psychosocial Factors ◽  
Disease Duration ◽  
Gastrointestinal Symptoms

scholarly journals Cancer-related psychosocial factors and self-reported changes in lifestyle among gynecological cancer survivors: cross-sectional analysis of PROFILES registry data

2021 ◽  
Author(s):  
Karin A. J. Driessen ◽  
Belle H. de Rooij ◽  
M. Caroline Vos ◽  
Dorry Boll ◽  
Johanna M. A. Pijnenborg ◽  
...  
Keyword(s):  
Physical Activity ◽  
Cancer Survivors ◽  
Psychosocial Factors ◽  
Initial Treatment ◽  
Gynecological Cancer ◽  
Gastrointestinal Symptoms ◽  
Cross Sectional ◽  
Body Change ◽  
Change Concerns ◽  
Gynecological Cancer Survivors

Abstract Purpose Obesity is prevalent in gynecological cancer survivors and is associated with impaired health outcomes. Concerns due to cancer and its treatment may impact changes in lifestyle after cancer. This study aimed to assess the association between cancer-related psychosocial factors and changes in physical activity and diet, 18 months after initial treatment among gynecological cancer survivors. Methods Cross-sectional data from the ROGY Care study were used, including endometrial and ovarian cancer patients treated with curative intent. The Impact of Cancer Scale (IOCv2) was used to assess cancer-related psychosocial factors. Self-reported changes in nutrients/food groups and in physical activity post-diagnosis were classified into change groups (less/equal/more). Multivariable logistic regression models were used to assess associations. Results Data from 229 cancer survivors (59% endometrial, 41% ovarian, mean age 66 ± 9.5, 70% tumor stage I) were analyzed. In total, 20% reported to eat healthier from diagnosis up to 18 months after initial treatment, 17% reported less physical activity and 20% more physical activity. Health awareness (OR 2.79, 95% CI: 1.38; 5.65), body change concerns (OR 3.04 95% CI: 1.71; 5.39), life interferences (OR 4.88 95% 2.29; 10.38) and worry (OR 2.62, 95% CI: 1.42; 4.85) were significantly associated with less physical activity up to 18 months after initial treatment whereby gastrointestinal symptoms were an important confounder. Conclusion(s) This study underlines the need to raise awareness of the benefits of a healthy lifestyle and to provide tailored lifestyle advice, taking into account survivors’ health awareness, body change concerns, life interferences, worry and gastrointestinal symptoms, in order to improve health behavior among gynecological cancer survivors. Trial Registration http://clinicaltrials.gov Identifier: NCT01185626, August 20, 2010

Effect of Type 2 Diabetes Mellitus and diabetic medication on Pulmonary Function

2021 ◽  
Vol 17 ◽  
Author(s):  
Alaa M. Hammad ◽  
Waleed Qirim ◽  
Ameen Alassi ◽  
Dana Hyassat
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Glycemic Control ◽  
Pulmonary Function ◽  
Disease Duration ◽  
Linear Regression Analysis ◽  
Forced Expiratory Volume ◽  
Control Group

Background: Type 2 diabetes mellitus (T2DM) is a chronic condition with an impairing effect on multiple organs. Numerous respiratory disorders have been observed in patients with T2DM. However, T2DM e ect on pulmonary function is ff inconclusive. Aims: In this study, we investigated the effect of T2DM on respiratory function and the correlation of glycemic control, diabetes duration and insulin intake. Methods: 1500 patients were recruited for this study, 560 having T2DM for at least a year were included in the final data, in addition to 540 healthy volunteers. Forced expiratory volume in one second (FEV1), forced vital capacity (FVC), forced expiratory flow at 25-75% (FEF 25-75%), as well as FEV1/FVC ratio values were measured. Results: A two-sample t-test showed that z-scores produced by Al-Qerem et al.’s equations for FEV1, FVC, and FEF 25-75% were significantly lower for the T2DM group than the control group (p < 0.01). FEV1/FVC ratio in T2DM group were significantly higher (p < 0.01). Multiple linear regression analysis found that glycemic control represented by HbA1c as well as disease duration were negatively associated with pulmonary function (p < 0.01). However, insulin intake was found to have no significant correlation with the pulmonary function. Conclusion: T2DM was linked to reduced pulmonary function and was consistent with a restrictive ventilation pattern. HbA1c as well as disease duration were independent risk factors for reduced pulmonary function.

scholarly journals Diabetic Gastroparesis

2019 ◽  
Vol 40 (5) ◽  
pp. 1318-1352 ◽  
Author(s):  
Adil E Bharucha ◽  
Yogish C Kudva ◽  
David O Prichard
Keyword(s):  
Glycemic Control ◽  
Gastrointestinal Symptoms ◽  
Outlet Obstruction ◽  
Diabetic Gastroparesis ◽  
Oral Nutrition ◽  
Ghrelin Receptor ◽  
Receptor Agonists ◽  
Wireless Motility Capsule ◽  
Upper Gastrointestinal Symptoms

AbstractThis review covers the epidemiology, pathophysiology, clinical features, diagnosis, and management of diabetic gastroparesis, and more broadly diabetic gastroenteropathy, which encompasses all the gastrointestinal manifestations of diabetes mellitus. Up to 50% of patients with type 1 and type 2 DM and suboptimal glycemic control have delayed gastric emptying (GE), which can be documented with scintigraphy, 13C breath tests, or a wireless motility capsule; the remainder have normal or rapid GE. Many patients with delayed GE are asymptomatic; others have dyspepsia (i.e., mild to moderate indigestion, with or without a mild delay in GE) or gastroparesis, which is a syndrome characterized by moderate to severe upper gastrointestinal symptoms and delayed GE that suggest, but are not accompanied by, gastric outlet obstruction. Gastroparesis can markedly impair quality of life, and up to 50% of patients have significant anxiety and/or depression. Often the distinction between dyspepsia and gastroparesis is based on clinical judgement rather than established criteria. Hyperglycemia, autonomic neuropathy, and enteric neuromuscular inflammation and injury are implicated in the pathogenesis of delayed GE. Alternatively, there are limited data to suggest that delayed GE may affect glycemic control. The management of diabetic gastroparesis is guided by the severity of symptoms, the magnitude of delayed GE, and the nutritional status. Initial options include dietary modifications, supplemental oral nutrition, and antiemetic and prokinetic medications. Patients with more severe symptoms may require a venting gastrostomy or jejunostomy and/or gastric electrical stimulation. Promising newer therapeutic approaches include ghrelin receptor agonists and selective 5-hydroxytryptamine receptor agonists.

Diabetic Polyneuropathy : Impact of Disease Duration and Glycemic Control

2014 ◽  
Vol 9 (4) ◽  
pp. 48-54
Author(s):  
Qassim H. Abdullah ◽  
Sherwan H. Omar ◽  
Mohammed O. Mohammed
Keyword(s):  
Glycemic Control ◽  
Disease Duration ◽  
Diabetic Polyneuropathy

Prospective Study on Influence of Psychosocial Factors on Glycemic Control in Japanese Patients With Type 2 Diabetes

2006 ◽  
Vol 47 (3) ◽  
pp. 240-246 ◽  
Author(s):  
Rika Nakahara ◽  
Kazuhiro Yoshiuchi ◽  
Hiroaki Kumano ◽  
Yoko Hara ◽  
Hiroyuki Suematsu ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Glycemic Control ◽  
Prospective Study ◽  
Psychosocial Factors ◽  
Japanese Patients

scholarly journals Gut bacterial tyrosine decarboxylase gene abundance associates with disease duration, medication exposure, and gastrointestinal symptoms in a longitudinal cohort of Parkinson's disease patients.

2021 ◽  
Author(s):  
Sebastiaan P van Kessel ◽  
Petri Auvinen ◽  
Filip Scheperjans ◽  
Sahar El Aidy
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Drug Exposure ◽  
Disease Duration ◽  
Gastrointestinal Symptoms ◽  
Drug Efficacy ◽  
Positive Association ◽  
Significant Positive Association ◽  
Longitudinal Cohort ◽  
Gene Abundance

Gut microbiota influences the clinical response of a wide variety of orally administered drugs. However, the underlying mechanisms by which drug-microbiota interactions occur are still obscure. Previously, we reported that tyrosine decarboxylating (TDC) bacteria may restrict the levels of levodopa reaching the circulation in patients with Parkinson's disease (PD). We observed a significant positive association between disease duration and the abundance of the bacterial tdc-gene. The question arises whether increased exposure to anti-PD medication could affect the abundance of bacterial TDC, to ultimately impact drug efficacy. To this end, we investigated the potential association between anti-PD drug exposure and bacterial tdc-gene abundance over a time period of two years in a longitudinal cohort of PD patients and healthy controls. Our data reveal significant associations between tdc-gene abundance, anti-PD medication, and gastrointestinal symptoms and warrants further research on the effect of anti-PD medication on microbial changes and gastrointestinal-function.

Prevalence of diabetes and glycemic control in Mexico: national results from 2018 and 2020

2021 ◽  
Vol 63 (6, Nov-Dic) ◽  
pp. 725-733
Author(s):  
Ana Cristina Basto-Abreu ◽  
Nancy López-Olmedo ◽  
Rosalba Rojas-Martínez ◽  
Carlos A. Aguilar-Salinas ◽  
Vanessa Vianey De la Cruz-Góngora ◽  
...  
Keyword(s):  
Glycemic Control ◽  
Poisson Regression ◽  
Regression Models ◽  
Associated Factors ◽  
Disease Duration ◽  
Fasting Glucose ◽  
Older Age ◽  
Private Healthcare ◽  
Total Prevalence ◽  
Previous Diagnosis

Objective. To estimate the prevalence of diabetes (diagnosed and undiagnosed), glycemic control in Mexico, and its associated factors. Materials and methods. We used data from Ensanut 2018 (n=12 648) and 2020 (n=2 309). We defined diabetes as fasting glucose ≥126 mg/dl or HbA1c≥6.5% or previously diagnosed; glycemic control was defined as HbA1c<7%. We fitted Poisson regression models to assess the association between diabetes, glycemic control, and potential associated factors. Results. The total prevalence of diabetes was 16.8% in 2018 and 15.7% in 2020. In 2018, 38% of adults with diabetes were unaware of their disease, while in 2020 this figure was 29%. Glycemic control was observed in 42% of participants in 2018 and 39% in 2020. Longer disease duration was associated with lower glycemic control, while older age, having a diet, and being affiliated to IMSS, Pemex, Sedena, or private healthcare were associated with better control. Conclusion. Mexico is among the countries with the highest diabetes prevalence. A high proportion of adults with diabetes did not have a previous diagnosis, and the proportion with glycemic control is low. Strengthening screening to achieve a timely diagnosis, and improving glycemic control, should be key actions in the management of diabetes.

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