High tumour telomerase activity correlates with shortened patient survival and more advanced tumour stage in gastric but not in oesophageal adenocarcinoma

2001 ◽  
Vol 120 (5) ◽  
pp. A259-A260
Author(s):  
B USSELMANN ◽  
M NEWBOLD ◽  
A MORRIS ◽  
C NWOKOLO
Keyword(s):  
Patient Survival ◽  
Telomerase Activity ◽  
Oesophageal Adenocarcinoma ◽  
Tumour Stage ◽  
Advanced Tumour Stage

Apoptosis and cell-cycle regulatory proteins in colorectal carcinoma: relationship to tumour stage and patient survival

2001 ◽  
Vol 194 (4) ◽  
pp. 436-443 ◽  
Author(s):  
Mohamed A. Elkablawy ◽  
Perry Maxwell ◽  
Kate Williamson ◽  
Neil Anderson ◽  
Peter W. Hamilton
Keyword(s):  
Cell Cycle ◽  
Colorectal Carcinoma ◽  
Patient Survival ◽  
Regulatory Proteins ◽  
Tumour Stage ◽  
Cell Cycle Regulatory Proteins

Flow Cytometry in Bladder Tumours: Our Experience

1993 ◽  
Vol 60 (2) ◽  
pp. 158-161 ◽  
Author(s):  
M. De Siati ◽  
D. Grassi ◽  
N. Franzolin ◽  
F. Marchioretto ◽  
L.S. Azzolina
Keyword(s):  
Flow Cytometry ◽  
Initial Data ◽  
Patient Survival ◽  
Tumour Progression ◽  
Tumour Stage ◽  
Number Of Patients ◽  
Bladder Tumours

From January 1992 to January 1993, specimens from bladder tumours of 75 patients were analyzed by cytometry (FCM). Our data show a good correlation between tumour stage and grade, and tumour ploidy. Furthermore, aneuploid tumours showed progression more often than diploid tumours. A larger number of patients admitted to the study and a more prolonged period of follow-up will be necessary to confirm our initial data and to investigate whether a correlation exists between FCM and tumour progression and patient survival.

scholarly journals Immunohistochemically detectable bcl-2 expression in colorectal carcinoma: correlation with tumour stage and patient survival

1995 ◽  
Vol 72 (4) ◽  
pp. 981-985 ◽  
Author(s):  
D Öfner ◽  
K Riehemann ◽  
H Maier ◽  
B Riedmann ◽  
H Nehoda ◽  
...  
Keyword(s):  
Colorectal Carcinoma ◽  
Patient Survival ◽  
Tumour Stage

Telomerase activity and patient survival after surgery for gastric and oesophageal cancer

2001 ◽  
Vol 13 (8) ◽  
pp. 903-908 ◽  
Author(s):  
Bernhard Usselmann ◽  
Mark Newbold ◽  
Alan G. Morris ◽  
Chuka U. Nwokolo
Keyword(s):  
Oesophageal Cancer ◽  
Patient Survival ◽  
Telomerase Activity

Reduced CD151 expression is related to advanced tumour stage in urothelial bladder cancer

Pathology ◽  
2012 ◽  
Vol 44 (5) ◽  
pp. 448-452 ◽  
Author(s):  
Sarah Minner ◽  
Colin De Silva ◽  
Michael Rink ◽  
Roland Dahlem ◽  
Felix Chun ◽  
...  
Keyword(s):  
Bladder Cancer ◽  
Tumour Stage ◽  
Urothelial Bladder Cancer ◽  
Urothelial Bladder ◽  
Advanced Tumour Stage

scholarly journals HOXA9 Expression is Associated with Advanced Tumour Stage and Prognosis in Nasopharyngeal Carcinoma

2021 ◽  
Vol Volume 13 ◽  
pp. 4147-4154
Author(s):  
Tiancong Liu ◽  
Chao Ji ◽  
Yang Sun ◽  
Weiliang Bai
Keyword(s):  
Nasopharyngeal Carcinoma ◽  
Tumour Stage ◽  
Advanced Tumour Stage

scholarly journals Cytochrome 4Z1 Expression Is Correlated with Poor Prognosis in Patients with Cervical Cancer

2021 ◽  
Vol 28 (5) ◽  
pp. 3573-3584
Author(s):  
Yousef M. Al-saraireh ◽  
Fatemah O. F. O. Alshammari ◽  
Ahmed M. M. Youssef ◽  
Yahya M. Al-sarayra ◽  
Renata A. Al-saraireh ◽  
...  
Keyword(s):  
Cervical Cancer ◽  
Lymph Node ◽  
Cancer Patients ◽  
Poor Prognosis ◽  
Patient Survival ◽  
Tumour Stage ◽  
Tumour Invasion ◽  
Cervical Cancers ◽  
Node Metastasis ◽  
Normal Cervix

Background: cervical cancer is one of the most common malignancies in women worldwide and its management remains challenging and complex. As Cytochrome4Z1 (CYP4Z1) is overexpressed in many tumours, its expression in cervical cancer is unknown. Therefore, the present study aimed to evaluate CYP4Z1 expression in cervical cancers. Methods: CYP4Z1 expression was immunohistochemically assessed in 100 cases of cervical cancers along with ten normal cervix tissues, and the enzyme’s relationship to several clinicopathological features and survival was explored. Results: CYP4Z1 was strongly expressed in 55% of cervical cancer patients. Normal cervix samples were negative for CYP4Z1 expression. Importantly, this expression was significantly found in patients with the late stage of the disease, lymph node metastasis, and high tumour invasion (p < 0.05). Interestingly, CYP4Z1 expression was significantly correlated with shorter survival times of cervical cancer patients. Univariate analysis showed that CYP4Z1 expression, tumour stage, lymph node metastasis, and tumour invasion were significantly correlated with patient survival (p < 0.05). The multivariate analysis revealed that only CYP4Z1 expression and tumour stage were significantly correlated with patient survival (p < 0.05). Conclusions: CYP4Z1 expression is associated with cervical cancer patients’ survival and may serve as an independent predictor of poor prognosis in cervical cancer patients.

scholarly journals Serum Metabolomic and Lipoprotein Profiling of Pancreatic Ductal Adenocarcinoma Patients of African Ancestry

Metabolites ◽  
2021 ◽  
Vol 11 (10) ◽  
pp. 663
Author(s):  
Nnenna Elebo ◽  
Jones Omoshoro-Jones ◽  
Pascaline N. Fru ◽  
John Devar ◽  
Christiaan De Wet van Zyl ◽  
...  
Keyword(s):  
Pancreatic Ductal Adenocarcinoma ◽  
Patient Survival ◽  
African Ancestry ◽  
Metabolic Phenotype ◽  
Ductal Adenocarcinoma ◽  
Tumour Stage ◽  
Nmr Spectrum ◽  
Spearman’S Correlation ◽  
Patient Survival Time ◽  
Healthy Participants

Pancreatic ductal adenocarcinoma (PDAC) is a lethal cancer with a characteristic dysregulated metabolism. Abnormal clinicopathological features linked to defective metabolic and inflammatory response pathways can induce PDAC development and progression. In this study, we investigated the metabolites and lipoproteins profiles of PDAC patients of African ancestry. Nuclear Magnetic Resonance (NMR) spectroscopy was conducted on serum obtained from consenting individuals (34 PDAC, 6 Chronic Pancreatitis, and 6 healthy participants). Seventy-five signals were quantified from each NMR spectrum. The Liposcale test was used for lipoprotein characterization. Spearman’s correlation and Kapan Meier tests were conducted for correlation and survival analyses, respectively. In our patient cohort, the results demonstrated that levels of metabolites involved in the glycolytic pathway increased with the tumour stage. Raised ethanol and 3-hydroxybutyrate were independently correlated with a shorter patient survival time, irrespective of tumour stage. Furthermore, increased levels of bilirubin resulted in an abnormal lipoprotein profile in PDAC patients. Additionally, we observed that the levels of a panel of metabolites (such as glucose and lactate) and lipoproteins correlated with those of inflammatory markers. Taken together, the metabolic phenotype can help distinguish PDAC severity and be used to predict patient survival and inform treatment intervention.

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