M1391 Iron Metabolism and Iron-Deficiency Anemia in Patients With Chronic Pancreatitis

2010 ◽  
Vol 138 (5) ◽  
pp. S-395 ◽  
Author(s):  
Enrique Dominguez-Munoz ◽  
Margarita Castineira ◽  
Jose Larino-Noia ◽  
Maria Luaces ◽  
Julio Iglesias-Garcia
Keyword(s):  
Chronic Pancreatitis ◽  
Iron Deficiency ◽  
Iron Deficiency Anemia ◽  
Iron Metabolism ◽  
Deficiency Anemia

Iron Deficiency Anemia Associated with an Error of Iron Metabolism in Two Siblings: A Thirty Year Follow Up

Hematology ◽  
1996 ◽  
Vol 1 (1) ◽  
pp. 65-73 ◽  
Author(s):  
Susan K. Parsons ◽  
Mark D. Fleming ◽  
David G. Nathan ◽  
Nancy C. Andrews
Keyword(s):  
Iron Deficiency ◽  
Iron Deficiency Anemia ◽  
Iron Metabolism ◽  
Deficiency Anemia

scholarly journals Serum Concentration of Hepcidin as an Indicator of Iron Reserves in Children

2018 ◽  
Vol 37 (4) ◽  
pp. 456-464 ◽  
Author(s):  
Jelena Ćulafić ◽  
Jovanka Kolarović ◽  
Lato Pezo ◽  
Velibor Čabarkapa ◽  
Stanislava Nikolić ◽  
...  
Keyword(s):  
Iron Deficiency ◽  
Serum Concentration ◽  
Iron Deficiency Anemia ◽  
Iron Metabolism ◽  
Transferrin Saturation ◽  
The Body ◽  
Deficiency Anemia ◽  
Control Group ◽  
Hepcidin Level ◽  
Serum Hepcidin

SummaryBackground:Anemia represents a significant cause of maternal and perinatal mortality, as well as child mortality. The aim of the research was to determine the serum concentration of hepcidin in children aged 6 months to 2 years and adolescents aged 11 to 19 years which suffer from iron deficiency anemia and compare it with the serum concentration of hepcidin in the control groups, as well as to determine its connection with the parameters of the iron metabolism.Methods:The research included 173 examinees, 89 of them suffered from iron deficiency anemia and 84 did not suffer from iron deficiency anemia (the latter represented the control group). Blood samples were collected from all study participants. The samples were analyzed for complete blood count and parameters of iron metabolism. ELISA method was used for establishing serum hepcidin levels.Results:The research showed that the concentration of hepcidin is statistically lower in children (4.4 ng/mL) and adolescents (4.1 ng/mL) who suffer from iron deficiency anemia in comparison with the control group (14 ng/mL, 10 ng/mL, respectively). The positive correlation between serum hepcidin level and iron in the serum, ferritin, the mean corpuscular volume and transferrin saturation was confirmed, but the negative one occurred in serum hepcidin level, transferrin and reticulocytes.Conclusions:The age of the examinees does not influence the level of serum hepcidin which makes it a more sensitive indicator of the level of iron in the body. Besides this, serum hepcidin is a reliable biological marker for the assessment of iron deficiency anemia.

scholarly journals The Role of Erythroferrone Hormone as Erythroid Regulator of Hepcidin and Iron Metabolism during Thalassemia and in Iron Deficiency Anemia- A Short Review

2020 ◽  
pp. 55-59
Author(s):  
Tiba Sabah Talawy ◽  
Abd Elgadir A. Altoum ◽  
Asaad Ma Babker
Keyword(s):  
Iron Deficiency ◽  
Iron Deficiency Anemia ◽  
Iron Metabolism ◽  
Short Review ◽  
Deficiency Anemia ◽  
Blood Disorders ◽  
Iron Storage ◽  
Clinical Biomarkers ◽  
Potential Factor

Erythroferrone (ERFE) is a hormone produced by erythroblasts in the bone marrow in response to erythropoietin controlling iron storage release through its actions on hepcidin, which acts on hepatocytes to suppress expression of the hormone hepcidin. Erythroferrone now considered is one of potential clinical biomarkers for assessing erythropoiesis activity in patients with blood disorders regarding to iron imbalance. Since discovery of in 2014 by Dr. Leon Kautz and colleagues and till now no more enough studies in Erythroferrone among human, most studies are conducted in animals. In this review we briefly address the Role of Erythroferrone hormone as erythroid regulator of hepcidin and iron metabolism during thalassemia and in iron deficiency anemia. Studies in this review were identified through a search using the following electronic databases: PubMed, Academia, Scopus, Google Scholar, and another open database source. Conclusion: Most of studies concluded that, in people with thalassemia and iron deficiency anemia, erythroferrone levels in the blood are higher than in people without thalassemia and iron deficiency anemia. Knowing the mechanisms of erythroferrone as erythroid regulator of hepcidin and iron metabolism during thalassemia and in iron deficiency anemia important in the diagnosis and treatment for both conditions. The erythroferrone hormone may act as potential factor in physiological hepcidin suppressor in cases with iron deficiency anemia and thalassemia disease and play a key role in treatment process among those patients in status of iron deficiency                    or iron overload. However, till now few studies of the function of ERFE in humans because is recently discovered and remains to be investigated and most studies are conducted among animals.

scholarly journals Iron Deficiency Anemia Associated with an Error of Iron Metabolism in Two Siblings *

1964 ◽  
Vol 43 (3) ◽  
pp. 510-521 ◽  
Author(s):  
Nasrollah T. Shahidi ◽  
David G. Nathan ◽  
Louis K. Diamond
Keyword(s):  
Iron Deficiency ◽  
Iron Deficiency Anemia ◽  
Iron Metabolism ◽  
Deficiency Anemia

Revisiting Iron Metabolism, Iron Homeostasis and Iron Deficiency Anemia

2021 ◽  
Vol 67 (03/2021) ◽  
Author(s):  
Muhammad Saboor ◽  
Amtuz Zehra ◽  
Hassan Hamali ◽  
Abdullah Mobarki
Keyword(s):  
Iron Deficiency ◽  
Iron Deficiency Anemia ◽  
Iron Metabolism ◽  
Iron Homeostasis ◽  
Deficiency Anemia

The differential diagnostic of anemias associated with iron metabolism

2016 ◽  
Vol 22 (4) ◽  
pp. 213-221
Author(s):  
Nail’ A. Andreichev ◽  
E. N Andreicheva
Keyword(s):  
Iron Deficiency ◽  
Chronic Diseases ◽  
Iron Deficiency Anemia ◽  
Iron Metabolism ◽  
Clinical Laboratory ◽  
Microcytic Anemia ◽  
Blood Analysis ◽  
Deficiency Anemia ◽  
Actual Problem ◽  
Terrestrial Globe

The iron-deficiency conditions continue to be an actual problem all over the world being present in half of population of the terrestrial globe. The development of iron deficiency often depends on gender and age. In females specific role is played by hypermenorrhea and repeated pregnancies (iron deficiency and iron-deficiency anemia are found 6 times more often in females than in males). The anemia of chronic diseases by it prevalence takes second place after iron-deficiency anemia. The prevalence of anemia of chronic diseases in elder and senile age varies within range 2,9-61% in males and 3,3-41% in females. In young and mature age anemia of chronic diseases more often occurs in females. There are anemias when content of iron in organism and its resources are within limits of norm or higher - sideroahrestical anemias. The percentage of them in structure of hypochromic anemias is smallish. The diagnostic and differential diagnostic of anemias related to iron metabolism. The anemias are diverse according to clinical hematological characteristics. At selection of diagnostic schemes, treatment of anemias differs on leading pathogenic mechanism. However, to facilitate diagnostic and differential diagnostic the color indicator and morphological classifications are considered. The differentiated diagnostic of anemias is based on data of clinical, laboratory and instrumental analysis. The blood analysis under anemia is to take into account indices of Hb, size of erythrocytes, their saturation with Hb, average volume of erythrocytes, and average content of hemoglobin in erythrocytes, amount of reticulocytes and other cells permitting judging about character and activity of erythropoiesis. The article presents algorithm of examination of patient under hypochromic and microcytic anemia, diagnostic and differentiated diagnostic of acute post-hemorrhagic anemia, anemia of chronic course, iron-deficiency anemia, anemia of chronic diseases, sideroahrestical anemia, iron-saturated anemia due to leaden intoxication, inherent iron-saturated anemia of pharmaceutical genesis, thyroprival anemia and thalassemia.

scholarly journals New diagnostic tools for delineating iron status

Hematology ◽  
2019 ◽  
Vol 2019 (1) ◽  
pp. 327-336 ◽  
Author(s):  
Yelena Z. Ginzburg
Keyword(s):  
Bone Marrow ◽  
Iron Deficiency ◽  
Iron Deficiency Anemia ◽  
Iron Metabolism ◽  
Iron Status ◽  
Deficiency Anemia ◽  
Diagnostic Tools ◽  
Erythroid Precursor ◽  
Metabolism Regulation ◽  
Iron Sequestration

Abstract Recent advances in our understanding of iron metabolism regulation and crosstalk with erythropoiesis have provided insight into the pathophysiology of multiple disease conditions. For instance, the peptide hormone hepcidin is central to the regulation of iron metabolism. Its effect on cellular iron concentration involves binding ferroportin, the main iron export protein, resulting in its internalization and degradation and leading to iron sequestration within ferroportin-expressing cells. Furthermore, hepcidin regulation by erythropoiesis is attributed in large part to a bone marrow–derived hormone erythroferrone. Erythroferrone-induced hepcidin suppression in diseases of expanded hematopoiesis results in iron overload. Conversely, diseases, such as iron refractory iron deficiency anemia and anemia of chronic inflammation, are characterized by aberrantly increased hepcidin, resulting in iron sequestration and decreased circulating iron and eventually leading to iron-restricted erythropoiesis. Lastly, because iron functions in concert with erythropoietin to promote erythroid precursor survival, proliferation, and differentiation, iron deficiency anemia is a consequence not only of decreased hemoglobin synthesis in each cell but also, a decrease in erythropoietin responsiveness in the bone marrow. How to translate this new information to the clinical setting has not been fully elucidated. The purpose of this manuscript is to summarize current standard tools for identifying iron deficiency in anemic patients; explore the tools and context for evaluating novel markers, such as hepcidin, erythroferrone, and markers of the iron restriction response; and assess available evidence for how their use could increase our understanding of health outcomes in clinically challenging cases.

scholarly journals Pathogenetic and clinical features of iron deficiency anemia on the background of chronic pancreatitis

2017 ◽  
Vol 37 (3) ◽  
pp. 36-39
Author(s):  
L. S. Babinets ◽  
M. V. Palykhata
Keyword(s):  
Helicobacter Pylori ◽  
Small Intestine ◽  
Chronic Pancreatitis ◽  
Immune System ◽  
Iron Deficiency ◽  
Iron Deficiency Anemia ◽  
Cognitive Disorders ◽  
Deficiency Anemia ◽  
Old People ◽  
Risk Of Mortality

One of the leading reasons of anemia on the background of chronic pancreatitis is the atophic changes of the mucous membrane of the gastrointestinal tract, chronic enteritis, accompanied by accelerated passage of chyme in the intestine, malabsorption syndrome. In healthy people, the concentration of iron is carefully regulated by cells in the proximal parts of the small intestine, which regulate its intake to match the loss of element. Errors in iron balance frequently lead to iron deficiency anemia. Such patients often have the following states: cognitive disorders, greater risk of mortality and hospitalizations among adults and, especially, old people, violation of thermoregulation, dysfunction of the immune system, gastro-intestinal disorders, Helicobacter pylori infection.

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