Iron Sequestration
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2021 ◽  
Vol 448 ◽  
pp. 214188
Author(s):  
Ana V. Almeida ◽  
Ana J. Carvalho ◽  
Alice S. Pereira

2021 ◽  
Vol 2021 ◽  
pp. 1-11
Author(s):  
Muhammad Farrukh Nisar ◽  
Maryam Yousaf ◽  
Muhammad Saleem ◽  
Hamad Khalid ◽  
Kamal Niaz ◽  
...  

Background. Solar ultraviolet radiation A (UVA, 320-400 nm) is a significant risk factor leading to various human skin conditions such as premature aging or photoaging. This condition is enhanced by UVA-mediated iron release from cellular iron proteins affecting huge populations across the globe. Purpose. Quercetin-loaded zinc oxide nanoparticles ([email protected] NPs) were prepared to examine its cellular iron sequestration ability to prevent the production of reactive oxygen species (ROS) and inflammatory responses in HaCaT cells. Methods. [email protected] NPs were synthesized through a homogenous precipitation method, and the functional groups were characterized by Fourier transform infrared (FTIR) spectroscopy, whereas scanning electron microscopy (SEM) described the morphologies of NPs. MTT and qRT-PCR assays were used to examine cell viability and the expression levels of various inflammatory cytokines. The cyclic voltammetry (CV) was employed to evaluate the redox potential of quercetin-Fe3+/quercetin-Fe2+ complexes. Results. The material characterization results supported the loading of quercetin molecules on ZnO NPs. The CV and redox potential assays gave Fe-binding capability of quercetin at 0.15 mM and 0.3 mM of Fe(NO3)3. Cytotoxicity assays using [email protected] NPs with human HaCaT cells showed no cytotoxic effects and help regain cell viability loss following UVA (150 kJ/m2). Conclusion. [email protected] NPs showed that efficient quercetin release action is UV-controlled, and the released quercetin molecules have excellent antioxidant, anti-inflammatory, and iron sequestration potential. [email protected] NPs have superior biocompatibility to provide UVA protection and medication at once for antiphotoaging therapeutics.


Author(s):  
Devkar Aniket ◽  
Jadhav Sudha

Mucormycosis is an ailment that originates from a saprophyte. Mucorales are a group of a growing number of members who have mucormycosis. The environmental contamination with fungal spore and now in COVID-19 the high use of steroid, which increases the occasion of mucor. It is a worldwide infectious disease as well as there is no vaccine to treat mucormycosis. Therapies for mucormycosis involve a coordinated surgical and medical approach. Antifungal therapy, iron sequestration, and adjunctive therapy are the various therapies to treat mucormycosis that will discuss in the article. Also the pathogenesis, identification of mucormycosis will review here.


2021 ◽  
Vol 10 (27) ◽  
Author(s):  
Marit H. Koszewski ◽  
Sheyda Motevalli ◽  
Scott D. Soby

The surfaces of plants are colonized by a rich diversity of microbes but are largely unexplored. Here, we present the draft genome sequences of five Pseudomonas spp. isolated from cultivated cranberry fruit surfaces. Although the isolates represent four different species, their genomes all contain conserved iron-sequestration and uptake genes.


Author(s):  
Sovan Debnath ◽  
Biswapati Mandal ◽  
Susmit Saha ◽  
Dibyendu Sarkar ◽  
Kaushik Batabyal ◽  
...  

2021 ◽  
Author(s):  
Eric Yau ◽  
Todd M Umstead ◽  
Raz Abdulqadir ◽  
Kristin Fino ◽  
Zhiwei Guan ◽  
...  

Previous studies demonstrated that the host defense collectins, surfactant protein A and complement component 1q, modulate tissue-dependent macrophage activation, pathogen clearance, and regulatory macrophage functions through the receptor SP-R210, which consists of two isoforms SP-R210L and SP-R210S. These isoforms are encoded by alternatively spliced mRNAs of the Myo18A gene. The present study in conditional transgenic mice revealed novel age-related functions of the SP-R210L isoform in modulating pulmonary mechanics, iron sequestration in alveolar macrophages, and life-long maintenance of the alveolar macrophage population. Our findings support the novel idea that SP-R210L-deficient AMs undergo bi-directional epigenetic adaptation that results in chronic dysregulation of broncho-alveolar function, immune homeostasis, and maintenance of oncotic balance at the airway-capillary interface. Disruption of SP-R210L increases the risk for development of severe interstitial lung disease during development and aging.


CCS Chemistry ◽  
2020 ◽  
pp. 2655-2668
Author(s):  
Xiaodong Qi ◽  
Lei Yang ◽  
Ying Hou ◽  
Jiaqi Zhu ◽  
Ming Yang ◽  
...  

PLoS ONE ◽  
2020 ◽  
Vol 15 (12) ◽  
pp. e0240949
Author(s):  
Rodrigo Abreu ◽  
Lauren Essler ◽  
Pramod Giri ◽  
Frederick Quinn

Salmonellosis and listeriosis together accounted for more than one third of foodborne illnesses in the United States and almost half the hospitalizations for gastrointestinal diseases in 2018 while tuberculosis afflicted over 10 million people worldwide causing almost 2 million deaths. Regardless of the intrinsic virulence differences among Listeria monocytogenes, Salmonella enterica and Mycobacterium tuberculosis, these intracellular pathogens share the ability to survive and persist inside the macrophage and other cells and thrive in iron rich environments. Interferon-gamma (IFN-γ) is a central cytokine in host defense against intracellular pathogens and has been shown to promote iron export in macrophages. We hypothesize that IFN-γ decreases iron availability to intracellular pathogens consequently limiting replication in these cells. In this study, we show that IFN-γ regulates the expression of iron-related proteins hepcidin, ferroportin, and ferritin to induce iron export from macrophages. Listeria monocytogenes, S. enterica, and M. tuberculosis infections significantly induce iron sequestration in human macrophages. In contrast, IFN-γ significantly reduces hepcidin secretion in S. enterica and M. tuberculosis infected macrophages. Similarly, IFN-γ-activated macrophages express higher ferroportin levels than untreated controls even after infection with L. monocytogenes bacilli; bacterial infection greatly down-regulates ferroportin expression. Collectively, IFN-γ significantly inhibits pathogen-associated intracellular iron sequestration in macrophages and consequently retards the growth of intracellular bacterial pathogens by decreasing iron availability.


2020 ◽  
Author(s):  
Rodrigo Abreu ◽  
Lauren Essler ◽  
Pramod Giri ◽  
Fred Quinn

AbstractSalmonellosis and listeriosis together accounted for more than one third of foodborne illnesses in the United States and almost half the hospitalizations for gastrointestinal diseases in 2018 while tuberculosis afflicted over 10 million people worldwide causing almost 2 million deaths. Regardless of the intrinsic virulence differences among Listeria monocytogenes, Salmonella enterica and Mycobacterium tuberculosis, these intracellular pathogens share the ability to survive and persist inside the macrophage and other cells and thrive in iron rich environments. Interferon-gamma (IFN-γ) is a central cytokine in host defense against intracellular pathogens and has been shown to promote iron export in macrophages. We hypothesize that IFN-γ decreases iron availability to intracellular pathogens consequently limiting replication in these cells. In this study, we show that IFN-γ regulates the expression of iron-related proteins hepcidin, ferroportin, and ferritin to induce iron export from macrophages. Listeria monocytogenes, S. enterica, and M. tuberculosis infections significantly induce iron sequestration in human macrophages. In contrast, IFN-γ significantly reduces hepcidin secretion in S. enterica and M. tuberculosis infected macrophages. Similarly, IFN-γ-activated macrophages express higher ferroportin levels than untreated controls even after infection with L. monocytogenes bacilli; bacterial infection greatly down-regulates ferroportin expression. Collectively, IFN-γ significantly inhibits pathogen-associated intracellular iron sequestration in macrophages and consequently retards the growth of intracellular bacterial pathogens by decreasing iron availability.


2020 ◽  
Vol 11 ◽  
Author(s):  
Louis Alex Julien ◽  
Clémence Fau ◽  
Florence Baron ◽  
Sylvie Bonnassie ◽  
Catherine Guérin-Dubiard ◽  
...  

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