Accuracy of In-Vivo Optical Diagnosis of Colon Polyp Histology by Narrow Band Imaging (NBI) in Predicting Colonoscopy (CC) Surveillance Intervals (SI)

Background and Aim. It has been documented that angiogenesis is a largely unstudied component of the pathogenesis of ulcerative colitis (UC). Under narrow-band imaging (NBI) colonoscopy, the mucosal vascular pattern (MVP) can be visualized without the use of dyes. The aim of this study was to assess the grade of mucosal angiogenesis based on the MVP in UC. Methods. A total of 119 colorectal segments taken from 42 patients with UC were observed using NBI colonoscopy. The MVP was classified as follows: clear, obscure, or absent. Quantification of the degree of inflammation was performed using histological colitis scoring. Potent angiogenic activity was assessed by immunohistochemical staining for vascular endothelial growth factor (VEGF). Microvascular density was assessed using vessel counts as revealed by CD31 staining. The correlation between the MVP and histological grades of inflammation and angiogenesis was evaluated. Results. The MVP correlated well with the histological severity of inflammation. We also demonstrated an increasing level of microvascular density and VEGF staining along with the ordered types of MVPs. In addition, a statistically strong association existed between microvascular density and VEGF staining. Conclusions. NBI colonoscopy might be a useful tool for the in vivo assessment of the grade of mucosal angiogenesis in UC.

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Narrow Band Imaging with Magnification Endoscopy for Celiac Disease: Results from a Prospective, Single-Center Study

Diagnostic and Therapeutic Endoscopy ◽

10.1155/2013/580526 ◽

2013 ◽

Vol 2013 ◽

pp. 1-6 ◽

Cited By ~ 14

Author(s):

L. De Luca ◽

L. Ricciardiello ◽

M. B. L. Rocchi ◽

M. T. Fabi ◽

M. L. Bianchi ◽

...

Keyword(s):

Celiac Disease ◽

Narrow Band ◽

Narrow Band Imaging ◽

Villous Atrophy ◽

Upper Gastrointestinal Endoscopy ◽

Kappa Score ◽

Biopsy Specimens ◽

Surface Patterns ◽

Sensitivity Specificity

In celiac disease (CD), the intestinal lesions can be patchy and partial villous atrophy may elude detection at standard endoscopy (SE). Narrow Band Imaging (NBI) system in combination with a magnifying endoscope (ME) is a simple tool able to obtain targeted biopsy specimens. The aim of the study was to assess the correlation between NBI-ME and histology in CD diagnosis and to compare diagnostic accuracy between NBI-ME and SE in detecting villous abnormalities in CD. Forty-four consecutive patients with suspected CD undergoing upper gastrointestinal endoscopy have been prospectively evaluated. Utilizing both SE and NBI-ME, observed surface patterns were compared with histological results obtained from biopsy specimens using the k-Cohen agreement coefficient. NBI-ME identified partial villous atrophy in 12 patients in whom SE was normal, with sensitivity, specificity, and accuracy of 100%, 92.6%, and 95%, respectively. The overall agreement between NBI-ME and histology was significantly higher when compared with SE and histology (kappa score: 0.90 versus 0.46; P=0.001) in diagnosing CD. NBI-ME could help identify partial mucosal atrophy in the routine endoscopic practice, potentially reducing the need for blind biopsies. NBI-ME was superior to SE and can reliably predict in vivo the villous changes of CD.

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Narrow-band imaging vs. high definition white light for optical diagnosis of small colorectal polyps: a randomized multicenter trial

Endoscopy ◽

10.1055/s-0042-110650 ◽

2016 ◽

Vol 48 (10) ◽

pp. 909-915 ◽

Cited By ~ 13

Author(s):

Peter Klare ◽

Bernhard Haller ◽

Sandra Wormbt ◽

Ellen Nötzel ◽

Dirk Hartmann ◽

...

Keyword(s):

White Light ◽

Narrow Band ◽

Narrow Band Imaging ◽

Multicenter Trial ◽

Colorectal Polyps ◽

Optical Diagnosis ◽

High Definition

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Real-time optical diagnosis for diminutive colorectal polyps using narrow-band imaging: the VALID randomised clinical trial

Gut ◽

10.1136/gutjnl-2014-307742 ◽

2014 ◽

Vol 64 (10) ◽

pp. 1569-1577 ◽

Cited By ~ 30

Author(s):

Tonya Kaltenbach ◽

Amit Rastogi ◽

Robert V Rouse ◽

Kenneth R McQuaid ◽

Tohru Sato ◽

...

Keyword(s):

Clinical Trial ◽

Real Time ◽

Narrow Band ◽

Narrow Band Imaging ◽

Randomised Clinical Trial ◽

Colorectal Polyps ◽

Optical Diagnosis

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The impact of narrow band imaging for colon polyp detection: a multicenter randomized controlled trial by tandem colonoscopy

Journal of Gastroenterology ◽

10.1007/s00535-012-0575-2 ◽

2012 ◽

Vol 47 (10) ◽

pp. 1099-1107 ◽

Cited By ~ 46

Author(s):

Hiroaki Ikematsu ◽

Yutaka Saito ◽

Shinji Tanaka ◽

Toshio Uraoka ◽

Yasushi Sano ◽

...

Keyword(s):

Randomized Controlled Trial ◽

Narrow Band ◽

Narrow Band Imaging ◽

Controlled Trial ◽

Colon Polyp ◽

Polyp Detection ◽

Randomized Controlled ◽

Multicenter Randomized Controlled Trial ◽

The Impact

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Endoscopic diagnosis of laryngeal cancer and precancerous lesions by narrow band imaging

The Journal of Laryngology & Otology ◽

10.1017/s0022215110002033 ◽

2010 ◽

Vol 125 (3) ◽

pp. 288-296 ◽

Cited By ~ 106

Author(s):

X-G Ni ◽

S He ◽

Z-G Xu ◽

L Gao ◽

N Lu ◽

...

Keyword(s):

Sensitivity And Specificity ◽

Laryngeal Cancer ◽

Narrow Band ◽

Narrow Band Imaging ◽

Precancerous Lesions ◽

Type I ◽

Severe Dysplasia ◽

Laryngeal Lesions ◽

Type V

AbstractObjective:To investigate the characteristics of the laryngeal mucosal microvascular network in suspected laryngeal cancer patients, using narrow band imaging, and to evaluate the value of narrow band imaging endoscopy in the early diagnosis of laryngeal precancerous and cancerous lesions.Patients and methods:Eighty-five consecutive patients with suspected precancerous or cancerous laryngeal lesions were enrolled in the study. Endoscopic narrow band imaging findings were classified into five types (I to V) according to the features of the mucosal intraepithelial papillary capillary loops assessed.Results:A total of 104 lesions (45 malignancies and 59 nonmalignancies) was detected under white light and narrow band imaging modes. The sensitivity and specificity of narrow band imaging in detecting malignant lesions were 88.9 and 93.2 per cent, respectively. The intraepithelial papillary capillary loop classification, as determined by narrow band imaging, was closely associated with the laryngeal lesions' histological findings. Type I to IV lesions were considered nonmalignant and type V lesions malignant. For type Va lesions, the sensitivity and specificity of narrow band imaging in detecting severe dysplasia or carcinoma in situ were 100 and 79.5 per cent, respectively. In patients with type Vb and Vc lesions, the sensitivity and specificity of narrow band imaging in detecting invasive carcinoma were 83.8 and 100 per cent, respectively.Conclusion:Narrow band imaging is a promising approach enabling in vivo differentiation of nonmalignant from malignant laryngeal lesions by evaluating the morphology of mucosal capillaries. These results suggest endoscopic narrow band imaging may be useful in the early detection of laryngeal cancer and precancerous lesions.

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