325 CELF2 Induced Splicing Results in Loss of the Bir Domain in Survivin: Critical Role of XIAP in Radiation Induced Mitotic Catastrophe

2012 ◽  
Vol 142 (5) ◽  
pp. S-75
Author(s):  
David Standing ◽  
Prabhu Ramamoorthy ◽  
Parthasarathy Rangarajan ◽  
Dharmalingam Subramaniam ◽  
Satish Ramalingam ◽  
...  
Keyword(s):  
Critical Role ◽  
Mitotic Catastrophe ◽  
Radiation Induced ◽  
Bir Domain

Critical Role of P-Selectin and Lymphocyte Function Antigen-1 in Radiation-Induced Leukocyte-Endothelial Cell Interactions in the Colon

2007 ◽  
Vol 50 (12) ◽  
pp. 2194-2202 ◽  
Author(s):  
Andrada Mihaescu ◽  
Charlotte Thornberg ◽  
Sören Mattsson ◽  
Yusheng Wang ◽  
Bengt Jeppsson ◽  
...  
Keyword(s):  
Endothelial Cell ◽  
Critical Role ◽  
Cell Interactions ◽  
Lymphocyte Function ◽  
Radiation Induced

scholarly journals Role for polo-like kinase 4 in mediation of cytokinesis

2019 ◽  
Vol 116 (23) ◽  
pp. 11309-11318 ◽  
Author(s):  
Michael F. Press ◽  
Bin Xie ◽  
Simon Davenport ◽  
Yu Zhou ◽  
Roberta Guzman ◽  
...  
Keyword(s):  
Cell Division ◽  
Kinase Activity ◽  
Critical Role ◽  
Mitotic Catastrophe ◽  
Centrosome Duplication ◽  
Cleavage Furrow ◽  
Molecule Inhibitor ◽  
Colorectal Cancer Cells ◽  
Spindle Midzone

The mitotic protein polo-like kinase 4 (PLK4) plays a critical role in centrosome duplication for cell division. By using immunofluorescence, we confirm that PLK4 is localized to centrosomes. In addition, we find that phospho-PLK4 (pPLK4) is cleaved and distributed to kinetochores (metaphase and anaphase), spindle midzone/cleavage furrow (anaphase and telophase), and midbody (cytokinesis) during cell division in immortalized epithelial cells as well as breast, ovarian, and colorectal cancer cells. The distribution of pPLK4 midzone/cleavage furrow and midbody positions pPLK4 to play a functional role in cytokinesis. Indeed, we found that inhibition of PLK4 kinase activity with a small-molecule inhibitor, CFI-400945, prevents translocation to the spindle midzone/cleavage furrow and prevents cellular abscission, leading to the generation of cells with polyploidy, increased numbers of duplicated centrosomes, and vulnerability to anaphase or mitotic catastrophe. The regulatory role of PLK4 in cytokinesis makes it a potential target for therapeutic intervention in appropriately selected cancers.

scholarly journals The Protective Roles of ROS-Mediated Mitophagy on125I Seeds Radiation Induced Cell Death in HCT116 Cells

2016 ◽  
Vol 2016 ◽  
pp. 1-18 ◽  
Author(s):  
Lelin Hu ◽  
Hao Wang ◽  
Li Huang ◽  
Yong Zhao ◽  
Junjie Wang
Keyword(s):  
Cell Fate ◽  
Target Genes ◽  
Radiation Treatment ◽  
Tumor Therapy ◽  
Critical Role ◽  
Mitochondrial Ros ◽  
Intracellular Ros ◽  
Radiation Induced ◽  
Hct116 Cells

For many unresectable carcinomas and locally recurrent cancers (LRC),125I seeds brachytherapy is a feasible, effective, and safe treatment. Several studies have shown that125I seeds radiation exerts anticancer activity by triggering DNA damage. However, recent evidence shows mitochondrial quality to be another crucial determinant of cell fate, with mitophagy playing a central role in this control mechanism. Herein, we found that125I seeds irradiation injured mitochondria, leading to significantly elevated mitochondrial and intracellular ROS (reactive oxygen species) levels in HCT116 cells. The accumulation of mitochondrial ROS increased the expression of HIF-1αand its target genes BINP3 and NIX (BINP3L), which subsequently triggered mitophagy. Importantly,125I seeds radiation induced mitophagy promoted cells survival and protected HCT116 cells from apoptosis. These results collectively indicated that125I seeds radiation triggered mitophagy by upregulating the level of ROS to promote cellular homeostasis and survival. The present study uncovered the critical role of mitophagy in modulating the sensitivity of tumor cells to radiation therapy and suggested that chemotherapy targeting on mitophagy might improve the efficiency of125I seeds radiation treatment, which might be of clinical significance in tumor therapy.

Development of Biomarkers for Radiation Biodosimetry and Medical Countermeasures Research: Current Status, Utility, and Regulatory Pathways

2021 ◽  
Author(s):  
Merriline M. Satyamitra ◽  
Andrea L. DiCarlo ◽  
Brynn A. Hollingsworth ◽  
Thomas A. Winters ◽  
Lanyn P. Taliaferro
Keyword(s):  
Critical Role ◽  
Current Status ◽  
Meeting Report ◽  
Exposure Level ◽  
Regulatory Pathways ◽  
Radiation Induced ◽  
Countermeasures Research ◽  
Medical Countermeasures ◽  
Radiation Biodosimetry

Biomarkers are important indicators of biological processes in health or disease. For this reason, they play a critical role in advanced development of radiation biodosimetry tools and medical countermeasures (MCMs). They can aid in the assessment of radiation exposure level, extent of radiation-induced injury, and/or efficacy of an MCM. This meeting report summarizes the presentations and discussions from the 2020 workshop titled, “Biomarkers in Radiation Biodosimetry and Medical Countermeasures,” sponsored by the Radiation and Nuclear Countermeasures Program (RNCP) at the National Institute of Allergy and Infectious Diseases (NIAID). The main goals of this meeting were to: 1. Provide an overview on biomarkers and to focus on the state of science with regards to biomarkers specific to radiation biodosimetry and MCMs; 2. Understand developmental challenges unique to the role of biomarkers in the fields of radiation biodosimetry and MCM development; and 3. Identify existing gaps and needs for translational application.

The Role of the SLP in Autism Spectrum Disorder Screening and Assessment

2008 ◽  
Vol 15 (2) ◽  
pp. 50-59 ◽  
Author(s):  
Amy Philofsky
Keyword(s):  
Language Development ◽  
Critical Role ◽  
Children With Autism ◽  
Autism Spectrum ◽  
Children With Asd ◽  
Prevalence Estimates ◽  
Notable Increase ◽  
Screening Assessment ◽  
Critical Components

AbstractRecent prevalence estimates for autism have been alarming as a function of the notable increase. Speech-language pathologists play a critical role in screening, assessment and intervention for children with autism. This article reviews signs that may be indicative of autism at different stages of language development, and discusses the importance of several psychometric properties—sensitivity and specificity—in utilizing screening measures for children with autism. Critical components of assessment for children with autism are reviewed. This article concludes with examples of intervention targets for children with ASD at various levels of language development.

A critical role of iNOS-derived Nitric Oxide (NO) and progesterone in implantation

1998 ◽  
Vol 5 (1) ◽  
pp. 115A-115A
Author(s):  
K CHWALISZ ◽  
E WINTERHAGER ◽  
T THIENEL ◽  
R GARFIELD
Keyword(s):  
Nitric Oxide ◽  
Critical Role
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