scholarly journals Age-Related Decrease in Abdominal Pain and Associated Structural- and Functional Mechanisms: An Exploratory Study in Healthy Individuals and Irritable Bowel Syndrome Patients

2021 ◽  
Vol 12 ◽  
Author(s):  
Abraham B. Beckers ◽  
Ellen Wilms ◽  
Zlatan Mujagic ◽  
Béla Kajtár ◽  
Kata Csekő ◽  
...  
Keyword(s):  
Young Adults ◽  
Irritable Bowel Syndrome ◽  
Abdominal Pain ◽  
Visceral Hypersensitivity ◽  
Healthy Individuals ◽  
Intestinal Health ◽  
Healthy Elderly ◽  
Age Related ◽  
Underlying Mechanisms ◽  
Irritable Bowel

Introduction: The world population is ageing, resulting in increased prevalence of age-related comorbidities and healthcare costs. Limited data are available on intestinal health in elderly populations. Structural and functional changes, including altered visceroperception, may lead to altered bowel habits and abdominal symptoms in healthy individuals and irritable bowel syndrome (IBS) patients. Our aim was to explore age-related changes in gastrointestinal symptoms and underlying mechanisms.Methods: In total, 780 subjects (IBS patients n = 463, healthy subjects n = 317) from two separate studies were included. Subjects were divided into different age groups ranging from young adult to elderly. Demographics and gastrointestinal symptom scores were collected from all participants using validated questionnaires. A subset of 233 IBS patients and 103 controls underwent a rectal barostat procedure to assess visceral hypersensitivity. Sigmoid biopsies were obtained from 10 healthy young adults and 10 healthy elderly. Expression of the visceral pain-associated receptors transient receptor potential (TRP) Ankyrin 1 (TRPA1) and Vanilloid 1 (TRPV1) genes were investigated by quantitative RT-PCR and immunofluorescence.Results: Both elderly IBS and healthy individuals showed significantly lower scores for abdominal pain (p < 0.001) and indigestion (p < 0.05) as compared to respective young adults. Visceral hypersensitivity was less common in elderly than young IBS patients (p < 0.001). Relative TRPA1 gene transcription, as well as TRPA1 and TRPV1 immunoreactivity were significantly lower in healthy elderly versus healthy young adults (p < 0.05).Conclusions: Our findings show an age-related decrease in abdominal pain perception. This may in part be related to decreased TRPA1 and/or TRPV1 receptor expression. Further studies are needed to reveal precise underlying mechanisms and the associations with intestinal health.

680 Associations of Abdominal Pain and Visceral Hypersensitivity With Intestinal Microbiota in Patients With Irritable Bowel Syndrome

2015 ◽  
Vol 148 (4) ◽  
pp. S-131-S-132
Author(s):  
Yehuda Ringel ◽  
Jarkko Salojarvi ◽  
Tamar Ringel-Kulka ◽  
Ian M. Carroll ◽  
Willem M. de Vos
Keyword(s):  
Irritable Bowel Syndrome ◽  
Abdominal Pain ◽  
Intestinal Microbiota ◽  
Visceral Hypersensitivity ◽  
Irritable Bowel

Modern Management of Irritable Bowel Syndrome: More Than Motility

2016 ◽  
Vol 34 (5) ◽  
pp. 566-573 ◽  
Author(s):  
Jan Tack ◽  
Tim Vanuytsel ◽  
Maura Corsetti
Keyword(s):  
Irritable Bowel Syndrome ◽  
Abdominal Pain ◽  
Receptor Antagonist ◽  
Sphincter Of Oddi ◽  
Phase Iii ◽  
Dietary Interventions ◽  
Large Variability ◽  
Underlying Mechanisms ◽  
Irritable Bowel ◽  
Meta Analyses

In the treatment of irritable bowel syndrome (IBS), loperamide seems efficacious for diarrhea and ispaghula for constipation, while musculotropic spasmolytics may relieve abdominal pain. Antidepressants were found to be efficacious for abdominal pain, but their tolerance may be problematic and the therapeutic effect varied largely between trials. While meta-analyses suggest efficacy of probiotics as a group, the quality of the trials is often suboptimal and there is large variability. Lubiprostone, a chloride channel activator, and linaclotide, a guanylyl cyclase-C agonist, showed favorable effects on multiple symptoms in IBS with constipation. For IBS with diarrhea (IBS-D), the 5-HT3 receptor antagonist ramosetron showed efficacy in men and women, but is currently only approved in Japan. A multicenter study with the anti-emetic 5-HT3 receptor antagonist ondansetron showed efficacy on stool pattern in IBS-D. The poorly absorbable antibiotic rifaximin and eluxadoline, a mu opioid receptor agonist and delta antagonist, both showed efficacy in phase III trials in IBS-D and were approved by the FDA. Eluxadoline was associated with increased occurrence of sphincter of Oddi spasm and biliary pancreatitis. The non-pharmacological treatment of IBS, with dietary interventions (mainly gluten elimination and low FODMAP (fructose, oligo-, di-, monosaccharides and polyols)) has received a lot of attention lately. While responder rates vary across studies, perhaps based on regional variations in dietary intake of FODMAPs, the dietary approach seems to have acquired recognition as a valid therapeutic alternative. Long-term studies and comparative studies with pharmacotherapy, as well as elucidation of the underlying mechanisms of action, are needed.

scholarly journals 5-oxoETE triggers nociception in constipation-predominant irritable bowel syndrome through MAS-related G protein–coupled receptor D

2018 ◽  
Vol 11 (561) ◽  
pp. eaal2171 ◽  
Author(s):  
Tereza Bautzova ◽  
James R. F. Hockley ◽  
Teresa Perez-Berezo ◽  
Julien Pujo ◽  
Michael M. Tranter ◽  
...  
Keyword(s):  
Irritable Bowel Syndrome ◽  
Abdominal Pain ◽  
G Protein ◽  
Visceral Hypersensitivity ◽  
Mechanical Stimuli ◽  
Drg Neurons ◽  
G Protein Coupled Receptor ◽  
Irritable Bowel ◽  
Nerve Recordings ◽  
G Protein Coupled

Irritable bowel syndrome (IBS) is a common gastrointestinal disorder that is characterized by chronic abdominal pain concurrent with altered bowel habit. Polyunsaturated fatty acid (PUFA) metabolites are increased in abundance in IBS and are implicated in the alteration of sensation to mechanical stimuli, which is defined as visceral hypersensitivity. We sought to quantify PUFA metabolites in patients with IBS and evaluate their role in pain. Quantification of PUFA metabolites by mass spectrometry in colonic biopsies showed an increased abundance of 5-oxoeicosatetraenoic acid (5-oxoETE) only in biopsies taken from patients with IBS with predominant constipation (IBS-C). Local administration of 5-oxoETE to mice induced somatic and visceral hypersensitivity to mechanical stimuli without causing tissue inflammation. We found that 5-oxoETE directly acted on both human and mouse sensory neurons as shown by lumbar splanchnic nerve recordings and Ca2+imaging of dorsal root ganglion (DRG) neurons. We showed that 5-oxoETE selectively stimulated nonpeptidergic, isolectin B4 (IB4)–positive DRG neurons through a phospholipase C (PLC)– and pertussis toxin–dependent mechanism, suggesting that the effect was mediated by a G protein–coupled receptor (GPCR). The MAS-related GPCR D (Mrgprd) was found in mouse colonic DRG afferents and was identified as being implicated in the noxious effects of 5-oxoETE. Together, these data suggest that 5-oxoETE, a potential biomarker of IBS-C, induces somatic and visceral hyperalgesia without inflammation in an Mrgprd-dependent manner. Thus, 5-oxoETE may play a pivotal role in the abdominal pain associated with IBS-C.

scholarly journals PATOGENESIS DAN DIAGNOSIS SINDROM KOLON IRITABEL

2012 ◽  
Vol 4 (3) ◽  
Author(s):  
Edwin Jim
Keyword(s):  
Irritable Bowel Syndrome ◽  
Abdominal Pain ◽  
Visceral Hypersensitivity ◽  
Enteric Infection ◽  
Functional Bowel Disorder ◽  
Bowel Habits ◽  
Infection Diagnosis ◽  
Rome Iii ◽  
Irritable Bowel ◽  
Bowel Disorder

Abstract: Irritable bowel syndrome (IBS) is a chronic functional bowel disorder characterized by abdominal pain or discomfort and alterations in bowel habits. Many factors play some important roles in the development of the IBS including abnormal motility, visceral hypersensitivity, and enteric infection. Diagnosis of IBS is based on Rome III criteria.Keywords: irritable bowel syndrome, pathogenesis, diagnosisAbstrak: Sindrom kolon iritabel (SKI) adalah penyakit gastrointestinal fungsional kronik yang ditandai oleh nyeri perut atau rasa tidak enak di perut dan gangguan kebiasaan defekasi. Banyak faktor yang menyebabkan terjadinya SKI antara lain gangguan motilitas, hipersensitivitas viseral, dan pasca infeksi usus. Saat ini kriteria diagnosis yang digunakan untuk SKI ialah kriteria Roma III.Kata kunci: sindrom kolon iritabel, patogenesis, diagnosis

Effectiveness of rifaximin in the treatment of abdominal pain at irritable bowel syndrome

2020 ◽  
Vol 0 (4) ◽  
pp. 22-28
Author(s):  
S. M. Tkach ◽  
A. E. Dorofeev ◽  
N. M. Mirzabaeva
Keyword(s):  
Irritable Bowel Syndrome ◽  
Abdominal Pain ◽  
Irritable Bowel
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