1023 VITAMIN D RECEPTOR REGULATES EPITHELIAL-MESENCHYMAL TRANSITION (EMT) TO INHIBIT INTESTINAL FIBROSIS IN EXPERIMENTAL INFLAMMATORY BOWEL DISEASE THROUGH BINDING TO P62/SQSTM1

2020 ◽  
Vol 158 (6) ◽  
pp. S-205
Author(s):  
YU MengLi ◽  
Chen Xueyang ◽  
Chaohui Yu
Keyword(s):  
Inflammatory Bowel Disease ◽  
Vitamin D ◽  
Vitamin D Receptor ◽  
Bowel Disease ◽  
Epithelial Mesenchymal Transition ◽  
Mesenchymal Transition ◽  
Intestinal Fibrosis ◽  
Experimental Inflammatory Bowel Disease ◽  
Inflammatory Bowel

Role of Epithelial-to-Mesenchymal Transition in Inflammatory Bowel Disease

2018 ◽  
Vol 13 (5) ◽  
pp. 659-668 ◽  
Author(s):  
Sara Lovisa ◽  
Giannicola Genovese ◽  
Silvio Danese
Keyword(s):  
Inflammatory Bowel Disease ◽  
Wound Healing ◽  
Bowel Disease ◽  
Molecular Mechanisms ◽  
Epithelial To Mesenchymal Transition ◽  
Clinical Manifestations ◽  
Mesenchymal Transition ◽  
Intestinal Fibrosis ◽  
Inflammatory Bowel

Abstract Intestinal fibrosis is an inevitable complication in patients with inflammatory bowel disease [IBD], occurring in its two major clinical manifestations: ulcerative colitis and Crohn’s disease. Fibrosis represents the final outcome of the host reaction to persistent inflammation, which triggers a prolonged wound healing response resulting in the excessive deposition of extracellular matrix, eventually leading to intestinal dysfunction. The process of epithelial-to-mesenchymal transition [EMT] represents an embryonic program relaunched during wound healing, fibrosis and cancer. Here we discuss the initial observations and the most recent findings highlighting the role of EMT in IBD-associated intestinal fibrosis and fistulae formation. In addition, we briefly review knowledge on the cognate process of endothelial-to-mesenchymal transition [EndMT]. Understanding EMT functionality and the molecular mechanisms underlying the activation of this mesenchymal programme will permit designing new therapeutic strategies to halt the fibrogenic response in the intestine.

Evaluation of Vitamin D Levels and Colonic Expression of the Vitamin D Receptor in Puerto Ricans With Inflammatory Bowel Disease

2015 ◽  
Vol 110 ◽  
pp. S836
Author(s):  
Priscilla M. Medero-Rodriguez ◽  
Yamilka Abreu-Delgado ◽  
Raymond A. Isidro ◽  
Alexandra Gonzalez ◽  
Gil Diaz ◽  
...  
Keyword(s):  
Inflammatory Bowel Disease ◽  
Vitamin D ◽  
Vitamin D Receptor ◽  
Bowel Disease ◽  
Puerto Ricans ◽  
Vitamin D Levels ◽  
Inflammatory Bowel

Association of Vitamin D Receptor Gene Polymorphisms with Inflammatory Bowel Disease

2006 ◽  
Vol 101 ◽  
pp. S435-S436
Author(s):  
Nosratollah Naderi ◽  
Alma Farnood ◽  
Manijeh Habibi ◽  
Faramarz Derakhshan ◽  
Zahra Motahari ◽  
...  
Keyword(s):  
Inflammatory Bowel Disease ◽  
Vitamin D ◽  
Vitamin D Receptor ◽  
Bowel Disease ◽  
Gene Polymorphisms ◽  
Receptor Gene ◽  
Vitamin D Receptor Gene ◽  
Inflammatory Bowel ◽  
Receptor Gene Polymorphisms

Efficacy of a potent and safe vitamin D receptor agonist for the treatment of inflammatory bowel disease

2010 ◽  
Vol 131 (1) ◽  
pp. 49-58 ◽  
Author(s):  
Gilles Laverny ◽  
Giuseppe Penna ◽  
Stefania Vetrano ◽  
Carmen Correale ◽  
Manuela Nebuloni ◽  
...  
Keyword(s):  
Inflammatory Bowel Disease ◽  
Vitamin D ◽  
Vitamin D Receptor ◽  
Bowel Disease ◽  
Receptor Agonist ◽  
Inflammatory Bowel
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