Sa1012 EFFECTS OF SYSTEMIC LUPUS ERYTHEMATOSUS ON CLINICAL OUTCOMES AND IN-PATIENT MORTALITY AMONG HOSPITALIZED PATIENTS WITH DIVERTICULITIS: A NATIONWIDE INPATIENT SAMPLE ANALYSIS

The aim of this study was to estimate the impact of the haematological manifestations of systemic lupus erythematosus (SLE) on mortality in hospitalized patients. For that purpose a case–control study of hospitalized patients in a medical referral centre from January 2009 to December 2014 was performed. For analysis, patients hospitalized for any haematological activity of SLE ( n = 103) were compared with patients hospitalized for other manifestations of SLE activity or complications of treatment ( n = 206). Taking as a variable outcome hospital death, an analysis of potential associated factors was performed. The most common haematological manifestation was thrombocytopenia (63.1%), followed by haemolytic anaemia (30%) and neutropenia (25.2%). In the group of haematological manifestations, 17 (16.5%) deaths were observed compared to 10 (4.8%) deaths in the control group ( P < 0.001). The causes of death were similar in both groups. In the analysis of the variables, it was found that only haematological manifestations were associated with intra-hospital death (odds ratio 3.87, 95% confidence interval 1.8–88, P < 0.001). Our study suggests that apparently any manifestation of haematological activity of SLE is associated with poor prognosis and contributes to increased hospital mortality.

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Clinical outcomes of hydronephrosis in patients with systemic lupus erythematosus

International Journal of Rheumatic Diseases ◽

10.1111/1756-185x.12599 ◽

2015 ◽

Vol 19 (12) ◽

pp. 1317-1321 ◽

Cited By ~ 3

Author(s):

Seokchan Hong ◽

Yong-Gil Kim ◽

Soo Min Ahn ◽

Seung-Hyeon Bae ◽

Doo-Ho Lim ◽

...

Keyword(s):

Systemic Lupus Erythematosus ◽

Clinical Outcomes ◽

Lupus Erythematosus ◽

Systemic Lupus

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Clinical outcomes of systemic lupus erythematosus patients undergoing continuous ambulatory peritoneal dialysis

Nephrology Dialysis Transplantation ◽

10.1093/ndt/gfi060 ◽

2005 ◽

Vol 20 (12) ◽

pp. 2797-2802 ◽

Cited By ~ 34

Author(s):

Yui Pong Siu ◽

Kay Tai Leung ◽

Matthew Ka Hang Tong ◽

Tze Hoi Kwan ◽

Chi Chiu Mok

Keyword(s):

Systemic Lupus Erythematosus ◽

Peritoneal Dialysis ◽

Clinical Outcomes ◽

Continuous Ambulatory Peritoneal Dialysis ◽

Lupus Erythematosus ◽

Systemic Lupus

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Infection in Southern Chinese Patients with Systemic Lupus Erythematosus: Spectrum, Drug Resistance, Outcomes, and Risk Factors

The Journal of Rheumatology ◽

10.3899/jrheum.151523 ◽

2016 ◽

Vol 43 (9) ◽

pp. 1650-1656 ◽

Cited By ~ 24

Author(s):

Dongying Chen ◽

Jingyi Xie ◽

Haihong Chen ◽

Ying Yang ◽

Zhongping Zhan ◽

...

Keyword(s):

Risk Factors ◽

Systemic Lupus Erythematosus ◽

Viral Infection ◽

Fungal Infection ◽

Lupus Erythematosus ◽

Renal Involvement ◽

Hospitalized Patients ◽

Chinese Patients ◽

Systemic Lupus ◽

Accumulated Dose

Objective.To investigate the spectrum, antibiotic-resistant pattern, risk factors, and outcomes of infection in patients hospitalized with systemic lupus erythematosus (SLE).Methods.We collected the clinical and microbiological data from hospitalized patients with SLE with infection between June 2005 and June 2015, and then conducted retrospective analyses.Results.Among our sample of 3815 hospitalized patients, 1321 (34.6%) were diagnosed with infection. The majority (78.3%) of infection occurred within 5 years of SLE onset. Bacterial infection was predominant (50.6%), followed by viral infection (36.4%) and fungal infection (12.5%). The lungs (33.7%) and upper respiratory tracts (26.3%) were most commonly affected. Gram-negative bacteria (GNB) were predominant over gram-positive bacteria (178 isolates vs 90 isolates). The most frequently isolated bacteria were Escherichia coli (24.6%), followed by Acinetobacter baumannii (13.4%) and coagulase-negative Staphylococcus (13.4%). Multidrug-resistant (MDR) strains were detected in 26.9% of bacterial isolates. The most common fungus was Candida spp. (99 episodes), followed by Aspergillus (24 episodes) and Cryptococcus neoformans (13 episodes). The overall mortality rate for this cohort was 2.2%; 48 patients died of infection. Factors associated with bacterial and viral infection were higher Systemic Lupus Erythematosus Disease Activity Index, renal involvement, thrombocytopenia, accumulated dose of glucocorticoids (GC), and treatment with cyclophosphamide (CYC). Renal involvement, accumulated dose of GC, and treatment with CYC were associated with fungal infection.Conclusion.Infection was the leading cause of mortality in patients hospitalized with SLE. There were some notable features of infection in Chinese patients including early onset, higher proportion of respiratory tract involvement, predominance of GNB with emergence of MDR isolates, and a variety of pathogens.

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