Tu1871 THE CONCORDANCE OF SHORT FORM-36 HEALTH SURVEY SCORES WITH MAYO SCORES IN THE TOFACITINIB ULCERATIVE COLITIS CLINICAL PROGRAM

Abstract Background The Short Form-36 Health Survey version 2 (SF-36v2) is a generic health-related quality-of-life (HRQoL) instrument [1]. Tofacitinib is an oral, small molecule JAK inhibitor for the treatment of ulcerative colitis (UC). In these exploratory analyses the concordance between total and partial Mayo scores and SF-36v2 scores was evaluated in patients with UC in the Phase 3 tofacitinib 8-week OCTAVE Induction 1&2 (NCT01465763; NCT01458951) and 52-week OCTAVE Sustain (NCT01458574) studies. Methods A repeated measures regression model was used to evaluate the relationship between total and partial Mayo scores (as predictor) and SF-36v2 component and domain scores. A sensitivity analysis to assess the linearity assumption was performed using Mayo score as a categorical anchor (represented by integer values 0–12 [total] or 0–9 [partial]). Previous analyses identified clinically important differences (CIDs) in total and partial Mayo scores as changes of 3 points and 2.25 points, respectively [2]. Mean differences in SF-36v2 component and domain scores were compared with their recommended group-level CID thresholds [3]. Results Clinically meaningful differences of 3 points and 2.25 points in total and partial Mayo scores, respectively, were generally associated with clinically meaningful differences in SF-36v2 component and domain scores, with the exception of Role-Emotional with partial Mayo score in the pooled induction studies and with total Mayo score in the maintenance study. In the induction studies, a 3-point difference in total Mayo score was associated with a mean difference exceeding CIDs in both the SF-36v2 Physical Component Summary score (mean improvement 4.5; 95% confidence interval [CI] 4.2, 4.7) and Mental Component Summary score (mean improvement 5.0; 95% CI 4.6, 5.3). Results were closely aligned when Mayo score was used as a categorical or continuous anchor, supporting a linear relationship between Mayo score and SF-36v2 scores (Figure). Similar results were observed in the maintenance study, and when assessing the relationship of partial Mayo score with SF-36v2 scores. Conclusion Clinically meaningful decreases in disease activity, as measured by Mayo score, were associated with clinically meaningful benefits in HRQoL, as measured by SF-36v2 component and domain scores. These findings highlight the impact that disease activity has on HRQoL and may assist with articulating the treatment effect of tofacitinib on specific domains. References

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CONFORT EN LAS MUJERES CON FIBROMIALGIA

ACTIVIDAD FÍSICA Y DESARROLLO HUMANO ◽

10.24054/16927427.v1.n1.2015.2268 ◽

2017 ◽

Vol 7 (1) ◽

Author(s):

Marco Fredy Jaimes Laguado ◽

Nelson Adolfo Mariño Landazabal ◽

Carlos Gustavo Enciso Mattos

Keyword(s):

Health Survey ◽

Short Form ◽

San Juan ◽

Short Form 36 ◽

Sf 36 ◽

Las Mujeres

El presente trabajo de investigación tiene como fin determinar las mujeres con fibromialgia que laboran en la E.S.E Hospital San Juan de Dios de Pamplona a partir de la aplicación de los cuestionario estructurados Fibromialgia Impact Questionnaire (FIQ) Short Form 36 Health Survey (SF - 36). A su vez determinar el confort en Ellas, basado en el modelo de Katharine Kolcaba a través de la aplicación Del Instrumentos validados de la teoría de mediano rango, cuestionario general de comodidad (GCQ) identificando los tipos de confort (alivio, tranquilidad y trascendencia) desarrollado por la doctora Katherine Kolcaba. Para el logro de esta investigación se aplicaron los instrumentos a mujeres en rango de edad de 25 a 60 años que laboran en la E.S.E Hospital San Juan de Dios de Pamplona y que accedieron firmar el consentimiento informado durante, primer periodo académico del año 2012.

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Health-Related Quality of Life of Older Adults in Costa Rica as Measured by the Short-Form-36 Health Survey

Gerontology and Geriatric Medicine ◽

10.1177/2333721418782812 ◽

2018 ◽

Vol 4 ◽

pp. 233372141878281 ◽

Cited By ~ 1

Author(s):

Esmeralda Valdivieso-Mora ◽

Mirjana Ivanisevic ◽

Leslie A. Shaw ◽

Mauricio Garnier-Villarreal ◽

Zachary D. Green ◽

...

Keyword(s):

Quality Of Life ◽

Older Adults ◽

Costa Rica ◽

Health Survey ◽

Short Form ◽

Health Related Quality ◽

Short Form 36 ◽

Related Quality ◽

Health Related

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Functional Assessment of Cancer Therapy Bone Marrow Transplantation: tradução e validação

Revista de Saúde Pública ◽

10.1590/s0034-89102007000200013 ◽

2007 ◽

Vol 41 (2) ◽

pp. 260-268 ◽

Cited By ~ 10

Author(s):

Ana Paula Mastropietro ◽

Érika Arantes de Oliveira ◽

Manoel Antônio dos Santos ◽

Júlio César Voltarelli

Keyword(s):

Bone Marrow ◽

Bone Marrow Transplantation ◽

Cancer Therapy ◽

Health Survey ◽

Functional Assessment ◽

Marrow Transplantation ◽

Short Form ◽

Short Form 36 ◽

Sf 36 ◽

Post Hoc

OBJETIVO: Traduzir para o português e validar o questionário de qualidade de vida Functional Assessment of Cancer Therapy - Bone Marrow Transplantation (FACT-BMT) em pacientes transplantados de medula óssea. OBJETIVO: O estudo foi realizado em Ribeirão Preto, SP, em 2005. O FACT-BMT (versão 3) traduzido e a versão em português do Short Form-36 Health Survey (SF-36) foram aplicados simultaneamente em 55 pacientes consecutivos com leucemia, submetidos ao transplante e em seguimento. Dois parâmetros clínicos foram utilizados para testar a sensibilidade do questionário: tempo decorrido do transplante e presença ou não de doença do enxerto contra o hospedeiro. Foi utilizada a análise de variância (ANOVA) com o teste post hoc de Tukey. Aplicou-se o coeficiente alfa de Cronbach, padronizado para todas as questões, escore final e domínios. RESULTADOS: A média de idade dos pacientes foi 34,8±8,1 anos, com escolaridade média de 10,8±4,7 anos, sendo 78,1% do sexo feminino. A duração média de tempo pós-transplante foi de 29,8±32,19 meses. Nenhuma alteração do formato original do questionário foi observada no final do processo de tradução e adaptação cultural. A consistência interna foi alta (0,88). A correlação entre o questionário traduzido e o SF-36 variou de 0,35 a 0,57, considerada de moderada a boa para a maioria dos domínios de qualidade de vida. A avaliação das validades de construto e concorrente foi satisfatória e estatisticamente significativa. CONCLUSÕES: A versão para o português do FACT-BMT foi validada satisfatoriamente para a aplicação em pacientes brasileiros de ambos os sexos submetidos ao transplante de medula óssea.

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