Tu1927 THE EFFECTS OF CAROTENOID INGESTION ON THE EXPRESSION OF TIGHT JUNCTION PROTEIN IN INTESTINE WHICH WERE CORRELATED WITH GUT MICROBIOTA COMPOSITION

2020 ◽  
Vol 158 (6) ◽  
pp. S-1221-S-1222
Author(s):  
Kazuhiro Kamada ◽  
Ritsu Yasuda ◽  
Takaaki Murakami ◽  
Ryo Inoue ◽  
Katsura Mizushima ◽  
...  
Keyword(s):  
Gut Microbiota ◽  
Tight Junction ◽  
Tight Junction Protein ◽  
Microbiota Composition ◽  
Junction Protein ◽  
Gut Microbiota Composition

scholarly journals Effect of an Intermittent Meat Protein Diet on Colon Homeostasis

2021 ◽  
Vol 5 (Supplement_2) ◽  
pp. 424-424
Author(s):  
Xiaohui Li ◽  
Chunbao Li ◽  
Guanghong Zhou
Keyword(s):  
Body Weight ◽  
Gut Microbiota ◽  
Proinflammatory Cytokines ◽  
Dietary Protein ◽  
Real Life ◽  
Protein Diet ◽  
Microbiota Composition ◽  
Gut Health ◽  
Junction Protein ◽  
Gut Microbiota Composition

Abstract Objectives The level of dietary protein is a major factor determining gut health. The level of dietary protein is fluctuated in real life, which may affect colon homeostasis. However, it is still less known about it. Here, we investigated how an intermittent protein diet affected inflammatory, gut barrier and microbiota. Methods Six-week-old male C57BL/6J mice received either a casein or pork protein with (i) 20% protein (C), (ii) 5% protein, (iii) 40% protein, or intermittent diet, a diet alternating weekly between 5% protein and 40% protein ((iv) ending on 40% protein or (v) ending on 5% protein)) for up to 16 weeks. The gene expression of inflammatory cytokines, tight junction protein and gut microbiota composition were measured. Results The intermittent intake of casein decreased body weight, but intermittent pork protein diet didn't affect body weight. In casein group, the proinflammatory factors were highly upregulated in intermittent group ending on 5% protein, but the proinflammatory cytokines of intermittent group ending on 40% protein were not significantly affected. However, the two intermittent pork protein groups reduced the expression of proinflammatory cytokines. Additionally, intermittent diet altered gut microbiota composition. Intermittent casein group ending on 40% protein increased richness of gut microbiota, but intermittent pork protein group ending on 5% protein decreased richness and microbial diversity. Conclusions Intermittent diet indeed altered microbiota structure and colon health. In addition to protein level and source, dietary pattern is also an important parameter for host health. Funding Sources This work was funded by Ministry of Science and Technology (10000 Talent Project).

scholarly journals Gut microbiota, tight junction protein expression, intestinal resistance, bacterial translocation and mortality following cholestasis depend on the genetic background of the host

Gut Microbes ◽  
2013 ◽  
Vol 4 (4) ◽  
pp. 292-305 ◽  
Author(s):  
Samuel M. Alaish ◽  
Alexis D. Smith ◽  
Jennifer Timmons ◽  
Jose Greenspon ◽  
Daniel Eyvazzadeh ◽  
...  
Keyword(s):  
Gut Microbiota ◽  
Protein Expression ◽  
Tight Junction ◽  
Bacterial Translocation ◽  
Genetic Background ◽  
Tight Junction Protein ◽  
Tight Junction Protein Expression ◽  
Junction Protein

Tight Junction Protein ZO-1 Staining Method

2020 ◽  
Author(s):  
Keyword(s):  
Tight Junction ◽  
Staining Method ◽  
Tight Junction Protein ◽  
Junction Protein

Changes in Human Gut Microbiota Composition Are Linked to the Energy Metabolic Switch During Ten Days of Fasting

2019 ◽  
Author(s):  
Robin Mesnage ◽  
Franziska Grundler ◽  
Andreas Schwiertz ◽  
Yvon Le Maho ◽  
Françoise Wilhelmi de Toledo
Keyword(s):  
Gut Microbiota ◽  
Microbiota Composition ◽  
Human Gut ◽  
Metabolic Switch ◽  
Human Gut Microbiota ◽  
Gut Microbiota Composition

Endothelial Tpl2 Regulates Vascular Barrier Function Via Tight Junction Protein Claudin-5 Promoting CNS Cell Infiltration and Tumor Metastasis

2019 ◽  
Author(s):  
Aikaterini Nanou ◽  
Stefania Vetrano ◽  
Ute Schaeper ◽  
Steven Ley ◽  
George Kollias
Keyword(s):  
Tight Junction ◽  
Barrier Function ◽  
Tumor Metastasis ◽  
Tight Junction Protein ◽  
Cell Infiltration ◽  
Junction Protein
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