M.663 Cardiovascular risk profiles and mortality in old age ? A longitudinal approach. The Berlin aging study (base)

Background: The aim of this epidemiological study is to examine the prevalence and correlates of psychotropic drug use in the very old and to evaluate the appropriateness of psychotropic drug use in very old age.Methods: Data from the Berlin Aging Study (BASE), a multidisciplinary study of an age- and gender-stratified, randomly selected sample of elderly people living in Berlin are presented. Over-sampling, especially very old men, allows for powerful analyses of this population. All participants went through extensive psychiatric and somatic examinations. Medication intake was assessed by different data sources (interviewing patients and their family physicians, drug inspection at home). Results were brought together in a consensus-conference and research physicians gave operationalized ratings of medication appropriateness.Results: The prevalence of elderly people who were taking at least one psychotropic medication within the 14 days immediately preceding investigation was 29.8%. Of these medications, 68.4% had been taken for longer than one year. There was no effect of age or gender on the scope of psychotropic drug use. Benzodiazepines were taken by 19.8% of the elderly. Antidepressants, neuroleptics and anti-dementia drugs were taken by about 3–4% each. People taking psychotropic drugs had significantly higher levels of psychiatric morbidity, as measured by syndromes and specified diagnoses. Psychotropic drugs were significantly less often judged to be indicated than somatic medications. This is mostly due to benzodiazepines.Conclusions: Psychotropic drug use is common in old age, but there is no additional increase in usage beyond the age of 70. Intake of psychotropics is mostly oriented at symptoms or syndromes, which explains why benzodiazepines are still the most commonly prescribed psychotropics

Download Full-text

The fate of cognition in very old age: Six-year longitudinal findings in the Berlin Aging Study (BASE).

Psychology and Aging ◽

10.1037/0882-7974.18.2.318 ◽

2003 ◽

Vol 18 (2) ◽

pp. 318-331 ◽

Cited By ~ 133

Author(s):

Tania Singer ◽

Paul Verhaeghen ◽

Paolo Ghisletta ◽

Ulman Lindenberger ◽

Paul B. Baltes

Keyword(s):

Old Age ◽

Very Old ◽

Aging Study ◽

Very Old Age ◽

Study Base

Download Full-text

Faculty Opinions recommendation of Differential effects of selective cyclooxygenase-2 inhibitors on vascular smooth muscle ion channels may account for differences in cardiovascular risk profiles.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.1166971.630074 ◽

2009 ◽

Author(s):

David Taylor

Keyword(s):

Smooth Muscle ◽

Cardiovascular Risk ◽

Ion Channels ◽

Vascular Smooth Muscle ◽

Cyclooxygenase 2 ◽

Risk Profiles ◽

Differential Effects ◽

Cyclooxygenase 2 Inhibitors

Download Full-text

PP027-MON THE ROLE OF LP(A) IN DIABETES MELLITUS AND INSULIN RESISTENCE – INVESTIGATION WITHIN THE BERLIN AGING STUDY BASE-II

Clinical Nutrition ◽

10.1016/s0261-5614(13)60339-8 ◽

2013 ◽

Vol 32 ◽

pp. S133

Author(s):

N. Buchmann ◽

U. Kassner ◽

K. Norman ◽

E. Steinhagen-Thiessen ◽

I. Demuth ◽

...

Keyword(s):

Diabetes Mellitus ◽

Insulin Resistence ◽

Aging Study ◽

Study Base

Download Full-text

Abstract TP207: Sex Differences in Cardiovascular Risk Profiles of Patients with Diabetes in the Greater Cincinnati/ Northern Kentucky Stroke Study

Stroke ◽

10.1161/str.48.suppl_1.tp207 ◽

2017 ◽

Vol 48 (suppl_1) ◽

Author(s):

Tracy E Madsen ◽

Jane C Khoury ◽

Kathleen Alwell ◽

Charles J Moomaw ◽

Stacie L Demel ◽

...

Keyword(s):

Cardiovascular Risk ◽

Stroke Risk ◽

Negative Impact ◽

Age Difference ◽

Risk Profiles ◽

Chi Square ◽

Adult Age ◽

Stroke Study ◽

Patients With Diabetes ◽

History Of

Introduction: Diabetes mellitus (DM) carries a greater stroke risk for females than males, possibly because of a difference in cardiovascular risk profiles between females and males with DM. Our aim was to compare the sex-specific risk factor profiles for patients with DM with those without DM among patients with acute ischemic stroke (AIS) in the Greater Cincinnati/ Northern Kentucky Stroke Study (GCNKSS). Methods: The GCNKSS ascertained cases of AIS in 2005 and 2010 among adult (age ≥20 years) residents of a biracial population of 1.3 million. Past and current stroke risk factors, obtained via chart review, were compared between those with and without DM using chi-square to examine bivariate differences and multiple logistic regression to examine sex-specific profiles. P < 0.05 was considered statistically significant. Results: There were 3515 patients with incident AIS; 1919 (55%) were female, 697 (20%) were black, and 1146 (33%) had DM. A lower proportion of females with DM were over 65 years old compared with those without DM. The proportion of males >65 with DM was not significantly different from that of males without DM. Among both females and males with DM, significantly more were Black, obese, and had histories of hypertension, high cholesterol, CAD and myocardial infarction compared to those without DM. In sex-specific adjusted analyses, women with DM were significantly less likely to be over 65 and more likely to have CAD than women without DM, whereas age and CAD were not significant factors in differentiating the profiles of men with and without DM. Conclusions: The result that females had their strokes at a younger age if they had a history of DM, and that no such age difference existed in males, suggests that DM is more severe and has a greater negative impact on females than males. As opposed to males, females with DM were also more likely to have CAD compared to those without DM, consistent with a possible sex difference in the association between DM and vascular disease.

Download Full-text