3D MENISCAL KINEMATICS DURING JOINT MOTION AND LOADING: A NOVEL IN-VIVO MRI STUDY OF THE KNEE

2012 ◽  
Vol 45 ◽  
pp. S369
Author(s):  
Daniel Watling ◽  
Gemma Whatling ◽  
Dr. Cathy Holt
Keyword(s):  
Joint Motion ◽  
Mri Study

scholarly journals Assessment of Albumin ECM Accumulation and Inflammation as Novel In Vivo Diagnostic Targets for Multi-Target MR Imaging

Biology ◽  
2021 ◽  
Vol 10 (10) ◽  
pp. 964
Author(s):  
Jana Möckel ◽  
Julia Brangsch ◽  
Carolin Reimann ◽  
Jan O. Kaufmann ◽  
Ingolf Sack ◽  
...  
Keyword(s):  
Inductively Coupled Plasma ◽  
Endothelial Damage ◽  
Plaque Burden ◽  
Signal Loss ◽  
Inductively Coupled ◽  
Before And After ◽  
Plasma Mass Spectrometry ◽  
Magnetic Resonance Imaging Mri ◽  
Mri Study

Atherosclerosis is a progressive inflammatory vascular disease characterized by endothelial dysfunction and plaque burden. Extracellular matrix (ECM)-associated plasma proteins play an important role in disease development. Our magnetic resonance imaging (MRI) study investigates the feasibility of using two different molecular MRI probes for the simultaneous assessment of ECM-associated intraplaque albumin deposits caused by endothelial damage and progressive inflammation in atherosclerosis. Male apolipoprotein E-deficient (ApoE-/-)-mice were fed a high-fat diet (HFD) for 2 or 4 months. Another ApoE-/--group was treated with pravastatin and received a HFD for 4 months. T1- and T2*-weighted MRI was performed before and after albumin-specific MRI probe (gadofosveset) administration and a macrophage-specific contrast agent (ferumoxytol). Thereafter, laser ablation inductively coupled plasma mass spectrometry and histology were performed. With advancing atherosclerosis, albumin-based MRI signal enhancement and ferumoxytol-induced signal loss areas in T2*-weighted MRI increased. Significant correlations between contrast-to-noise-ratio (CNR) post-gadofosveset and albumin stain (R2 = 0.78, p < 0.05), and signal loss areas in T2*-weighted MRI with Perls’ Prussian blue stain (R2 = 0.83, p < 0.05) were observed. No interference of ferumoxytol with gadofosveset enhancement was detectable. Pravastatin led to decreased inflammation and intraplaque albumin. Multi-target MRI combining ferumoxytol and gadofosveset is a promising method to improve diagnosis and treatment monitoring in atherosclerosis.

scholarly journals Handedness in monkeys reflects hemispheric specialization within the central sulcus. An in vivo MRI study in right- and left-handed olive baboons

Cortex ◽  
2019 ◽  
Vol 118 ◽  
pp. 203-211 ◽  
Author(s):  
Konstantina Margiotoudi ◽  
Damien Marie ◽  
Nicolas Claidière ◽  
Olivier Coulon ◽  
Muriel Roth ◽  
...  
Keyword(s):  
Hemispheric Specialization ◽  
Central Sulcus ◽  
Olive Baboons ◽  
Left Handed ◽  
Mri Study

Effect of Arthroscopic Stabilization on In Vivo Glenohumeral Joint Motion and Clinical Outcomes in Patients With Anterior Instability

2015 ◽  
Vol 43 (11) ◽  
pp. 2800-2808 ◽  
Author(s):  
Cathryn D. Peltz ◽  
Timothy G. Baumer ◽  
Veronica Mende ◽  
Nicole Ramo ◽  
Nima Mehran ◽  
...  
Keyword(s):  
Clinical Outcomes ◽  
Glenohumeral Joint ◽  
Joint Motion ◽  
Arthroscopic Stabilization ◽  
Anterior Instability

Brain anatomy and ageing in non-demented adults with Down's syndrome: an in vivo MRI study

2009 ◽  
Vol 40 (4) ◽  
pp. 611-619 ◽  
Author(s):  
F. Beacher ◽  
E. Daly ◽  
A. Simmons ◽  
V. Prasher ◽  
R. Morris ◽  
...  
Keyword(s):  
Down's Syndrome ◽  
Down’S Syndrome ◽  
Brain Regions ◽  
Accelerated Ageing ◽  
Brain Anatomy ◽  
Parietal Lobes ◽  
Age Related ◽  
Brain Ageing ◽  
Mri Study

BackgroundPeople with Down's syndrome (DS) are at high risk for developing dementia in middle age. The biological basis for this is unknown. It has been proposed that non-demented adults with DS may undergo accelerated brain ageing.MethodWe used volumetric magnetic resonance imaging (MRI) and manual tracing to compare brain anatomy and ageing in 39 non-demented adults with DS and 42 healthy controls.ResultsIndividuals with DS had significant differences in brain anatomy. Furthermore, individuals with DS had a significantly greater age-related reduction in volume of frontal, temporal and parietal lobes, and a significantly greater age-related increase in volume of peripheral cerebrospinal fluid (CSF).ConclusionsNon-demented adults with DS have differences in brain anatomy and ‘accelerated’ ageing of some brain regions. This may increase their risk for age-related cognitive decline and Alzheimer's disease (AD).

Glenohumeral translation in ABER position during muscle activity in patients treated with Latarjet procedure: an in vivo MRI study

2015 ◽  
Vol 24 (2) ◽  
pp. 521-525 ◽  
Author(s):  
Giovanni Di Giacomo ◽  
Paolo Scarso ◽  
Andrea De Vita ◽  
Mario A. Rojas Beccaglia ◽  
Nicole Pouliart ◽  
...  
Keyword(s):  
Muscle Activity ◽  
Latarjet Procedure ◽  
Mri Study

The Relationship Between In-Vivo Glenohumeral Joint Motion and Joint Morphology in Rotator Cuff Repair Patients and Healthy Control Subjects

2011 ◽  
Author(s):  
Cathryn D. Peltz ◽  
Kristin Ciarelli ◽  
Jeffrey A. Haladik ◽  
Michael J. McDonald ◽  
Nicole Ramo ◽  
...  
Keyword(s):  
Rotator Cuff ◽  
Rotator Cuff Repair ◽  
Glenohumeral Joint ◽  
Rotator Cuff Tears ◽  
Joint Motion ◽  
Healthy Control ◽  
The Relationship ◽  
Cuff Repair

Rotator cuff tears are a common condition that adversely affect function and quality of life. Altered glenohumeral joint (GHJ) motion is believed to contribute to the development of rotator cuff tears. Previous research has demonstrated relationships between in-vivo joint motion and bony morphology (particularly in the knee [e.g., 1]), and similar relationships have been reported in cadaveric shoulder studies [2, 3]. However, the extent to which these relationships exist under in-vivo conditions or if these relationships are altered in shoulders with pathologic conditions is not known. Thus, the objective of this study was to assess the relationship between glenoid/humerus morphology and in-vivo GHJ motion in healthy control shoulders and rotator cuff repair patients. We hypothesized that a relationship exists between glenoid/humerus morphology and GHJ motion in healthy control shoulders, but that this relationship is altered in rotator cuff patients.

Development of an in-vivo method of wrist joint motion analysis

2005 ◽  
Vol 20 (2) ◽  
pp. 166-171 ◽  
Author(s):  
L. Leonard ◽  
D. Sirkett ◽  
G. Mullineux ◽  
G.E.B Giddins ◽  
A.W. Miles
Keyword(s):  
Motion Analysis ◽  
Wrist Joint ◽  
Joint Motion
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