Effect of Arthroscopic Stabilization on In Vivo Glenohumeral Joint Motion and Clinical Outcomes in Patients With Anterior Instability

Rotator cuff tears are a common condition that adversely affect function and quality of life. Altered glenohumeral joint (GHJ) motion is believed to contribute to the development of rotator cuff tears. Previous research has demonstrated relationships between in-vivo joint motion and bony morphology (particularly in the knee [e.g., 1]), and similar relationships have been reported in cadaveric shoulder studies [2, 3]. However, the extent to which these relationships exist under in-vivo conditions or if these relationships are altered in shoulders with pathologic conditions is not known. Thus, the objective of this study was to assess the relationship between glenoid/humerus morphology and in-vivo GHJ motion in healthy control shoulders and rotator cuff repair patients. We hypothesized that a relationship exists between glenoid/humerus morphology and GHJ motion in healthy control shoulders, but that this relationship is altered in rotator cuff patients.

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Associations between in-vivo glenohumeral joint motion and morphology

Journal of Biomechanics ◽

10.1016/j.jbiomech.2015.06.030 ◽

2015 ◽

Vol 48 (12) ◽

pp. 3252-3257 ◽

Cited By ~ 10

Author(s):

Cathryn D. Peltz ◽

George Divine ◽

Anne Drake ◽

Nicole L. Ramo ◽

Roger Zauel ◽

...

Keyword(s):

Glenohumeral Joint ◽

Joint Motion

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Validation of a New Model-Based Tracking Technique for Measuring Three-Dimensional, In Vivo Glenohumeral Joint Kinematics

Journal of Biomechanical Engineering ◽

10.1115/1.2206199 ◽

2006 ◽

Vol 128 (4) ◽

pp. 604-609 ◽

Cited By ~ 177

Author(s):

Michael J. Bey ◽

Roger Zauel ◽

Stephanie K. Brock ◽

Scott Tashman

Keyword(s):

Glenohumeral Joint ◽

Three Dimensional ◽

Joint Kinematics ◽

Joint Motion ◽

Radiographic Images ◽

New Model ◽

Tracking Technique ◽

Model Based ◽

Shoulder Motion

Shoulder motion is complex and significant research efforts have focused on measuring glenohumeral joint motion. Unfortunately, conventional motion measurement techniques are unable to measure glenohumeral joint kinematics during dynamic shoulder motion to clinically significant levels of accuracy. The purpose of this study was to validate the accuracy of a new model-based tracking technique for measuring three-dimensional, in vivo glenohumeral joint kinematics. We have developed a model-based tracking technique for accurately measuring in vivo joint motion from biplane radiographic images that tracks the position of bones based on their three-dimensional shape and texture. To validate this technique, we implanted tantalum beads into the humerus and scapula of both shoulders from three cadaver specimens and then recorded biplane radiographic images of the shoulder while manually moving each specimen’s arm. The position of the humerus and scapula were measured using the model-based tracking system and with a previously validated dynamic radiostereometric analysis (RSA) technique. Accuracy was reported in terms of measurement bias, measurement precision, and overall dynamic accuracy by comparing the model-based tracking results to the dynamic RSA results. The model-based tracking technique produced results that were in excellent agreement with the RSA technique. Measurement bias ranged from −0.126to0.199mm for the scapula and ranged from −0.022to0.079mm for the humerus. Dynamic measurement precision was better than 0.130mm for the scapula and 0.095mm for the humerus. Overall dynamic accuracy indicated that rms errors in any one direction were less than 0.385mm for the scapula and less than 0.374mm for the humerus. These errors correspond to rotational inaccuracies of approximately 0.25deg for the scapula and 0.47deg for the humerus. This new model-based tracking approach represents a non-invasive technique for accurately measuring dynamic glenohumeral joint motion under in vivo conditions. The model-based technique achieves accuracy levels that far surpass all previously reported non-invasive techniques for measuring in vivo glenohumeral joint motion. This technique is supported by a rigorous validation study that provides a realistic simulation of in vivo conditions and we fully expect to achieve these levels of accuracy with in vivo human testing. Future research will use this technique to analyze shoulder motion under a variety of testing conditions and to investigate the effects of conservative and surgical treatment of rotator cuff tears on dynamic joint stability.

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A Rare Complication of Tuberculous Meningitis Pediatric Anterior Glenohumeral Instability

Case Reports in Orthopedics ◽

10.1155/2012/385782 ◽

2012 ◽

Vol 2012 ◽

pp. 1-4 ◽

Cited By ~ 1

Author(s):

Kerem Bilsel ◽

Mehmet Erdil ◽

Mehmet Elmadag ◽

Hasan H. Ceylan ◽

Derya Celik ◽

...

Keyword(s):

Central Nervous System ◽

Tuberculous Meningitis ◽

Shoulder Instability ◽

Rare Complication ◽

Central Nervous System Infection ◽

Arthroscopic Stabilization ◽

Anterior Instability ◽

Glenohumeral Instability ◽

Rehabilitation Protocols ◽

Anterior Glenohumeral Instability

Dislocation and instability of the shoulder joint are rare occurrences in childhood. Traumatic, infectious, congenital, and neuromuscular causes of pediatric recurrent shoulder dislocations are reported before. Central nervous system infection in infancy may be a reason for shoulder instability during childhood. This situation, which causes a disability for children, can be treated successfully with arthroscopic stabilization of the shoulder and postoperative effective rehabilitation protocols. Tuberculous meningitis may be a reason for neuromuscular shoulder instability. We describe a 12-year-old child with a recurrent anterior instability of the shoulder, which developed after tuberculous meningitis at 18 months of age. We applied arthroscopic treatment and stabilized the joint.

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IL-15 Serum Concentrations and CD19 CAR T-Cell Therapy: Impact on Clinical Outcomes and In Vivo CAR T Cell Kinetics

Transplantation and Cellular Therapy ◽

10.1016/s2666-6367(21)00243-8 ◽

2021 ◽

Vol 27 (3) ◽

pp. S196-S197

Author(s):

Jordan Gauthier ◽

Cassie Chou ◽

Alexandre V. Hirayama ◽

Salvatore Fiorenza ◽

Erik Kimble ◽

...

Keyword(s):

T Cell ◽

Cell Therapy ◽

Clinical Outcomes ◽

Cell Kinetics ◽

Serum Concentrations ◽

T Cell Therapy ◽

Car T Cell ◽

Car T Cell Therapy ◽

Car T

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Long-term clinical outcomes after microfracture of the glenohumeral joint: minimum 8-year follow-up

Osteoarthritis and Cartilage ◽

10.1016/j.joca.2017.02.277 ◽

2017 ◽

Vol 25 ◽

pp. S162-S163

Author(s):

K.C. Wang ◽

E.J. Cotter ◽

R.M. Frank ◽

A. Davey ◽

C.P. Hannon ◽

...

Keyword(s):

Clinical Outcomes ◽

Glenohumeral Joint

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Suprapectoral vs. Intra Articular Biceps Tenodesis: A Comparison of Clinical Outcomes

Orthopaedic Journal of Sports Medicine ◽

10.1177/2325967118s00108 ◽

2018 ◽

Vol 6 (7_suppl4) ◽

pp. 2325967118S0010

Author(s):

Brian M. Godshaw ◽

Nicholas Kolodychuk ◽

Benjamin Bryan Browning ◽

Gerard Williams ◽

Rachel Burdette ◽

...

Keyword(s):

Clinical Outcomes ◽

Outcome Measures ◽

Glenohumeral Joint ◽

Short Form ◽

Biceps Tendon ◽

Biceps Tenodesis ◽

Measured Time ◽

Long Head ◽

Distally Based

Objectives: The long head of the biceps tendon is a frequent pain generator within the shoulder. It is subjected to trauma and wear within the glenohumeral joint and within the intertubercular groove. Tenodesis of this tendon is a common treatment option for patients experiencing biceps tendon related pain. There are several different techniques to perform this procedure. Proximal intra-articular tenodesis can be performed but leaves the tendon within the intertubercular groove. Alternatively, suprapectoral tenodesis can be performed removing the tendon from the bicipital groove and sheath while avoiding conversion to an open procedure. Further, suprapectoral tenodesis limits complications associated with an open distally based incision. Several studies have compared these techniques to tenotomy or open-subpectoral tenodesis. This is the first study to directly compare patient outcomes between intra-articular and suprapectoral bicep tenodeses. Methods: Retrospective review of patients undergoing intra-articular or suprapectoral arthroscopic biceps tenodesis from 2010 - 2015. Clinical outcomes were measured at set intervals post-operatively (3 months, 6 months, and 12 months) and compared to pre-operative scores. Outcome measures included short form-12, both physical (PSF) and mental (MSF) component scores, and the American Shoulder and Elbow Surgeons score (ASES). Results: A total of 96 patients were available for this study, 43 had intra-articular tenodesis and 56 had suprapectoral tenodesis. There was no difference in functional outcomes between intra and extra articular biceps tenodesis at 1-year post-operative. The intra-articular group had a quicker improvement in scores with the greatest increase at 3 months post-operatively, specifically in PSF group (p=0.016): however, this difference leveled off at 1-year follow up (p=0.238). The intra-articular group had greater absolute scores at all measured time points, but not significantly. Both groups showed improvement in all outcome measures and there was found to be no difference in changes for ASES, PSF, or MSF (p=0.262, p=0.489, and p=0.907 respectively). Conclusion: This study demonstrates that both intra-articular and surpapectoral techniques are acceptable options for biceps tenodesis. Despite leaving the biceps tendon within the glenohumeral joint and intertubercular groove, the intra-articular technique offers similar improvement in outcome measures to the suprapectoral technique.

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Detection System Design of the Glenohumeral Joint Motion Information

Proceedings of 5th International Conference on Vehicle, Mechanical and Electrical Engineering ◽

10.5220/0008867702220226 ◽

2019 ◽

Author(s):

Jianfeng Li ◽

Chunzhao Zhang ◽

Qiang Cao

Keyword(s):

System Design ◽

Glenohumeral Joint ◽

Detection System ◽

Joint Motion ◽

Motion Information

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Macrophages in Acute Myeloid Leukaemia: Significant Players in Therapy Resistance and Patient Outcomes

Frontiers in Cell and Developmental Biology ◽

10.3389/fcell.2021.692800 ◽

2021 ◽

Vol 9 ◽

Author(s):

Katerina E. Miari ◽

Monica L. Guzman ◽

Helen Wheadon ◽

Mark T. S. Williams

Keyword(s):

Acute Myeloid Leukaemia ◽

Myeloid Leukaemia ◽

Clinical Outcomes ◽

Patient Outcomes ◽

Therapy Resistance ◽

Research Field ◽

Cell Death Pathways ◽

Leukaemic Cells ◽

Acute Myeloid

Acute Myeloid Leukaemia (AML) is a commonly occurring severe haematological malignancy, with most patients exhibiting sub-optimal clinical outcomes. Therapy resistance significantly contributes towards failure of traditional and targeted treatments, disease relapse and mortality in AML patients. The mechanisms driving therapy resistance in AML are not fully understood, and approaches to overcome therapy resistance are important for curative therapies. To date, most studies have focused on therapy resistant mechanisms inherent to leukaemic cells (e.g., TP53 mutations), overlooking to some extent, acquired mechanisms of resistance through extrinsic processes. In the bone marrow microenvironment (BMME), leukaemic cells interact with the surrounding bone resident cells, driving acquired therapy resistance in AML. Growing evidence suggests that macrophages, highly plastic immune cells present in the BMME, play a role in the pathophysiology of AML. Leukaemia-supporting macrophage subsets (CD163+CD206+) are elevated in preclinical in vivo models of AML and AML patients. However, the relationship between macrophages and therapy resistance in AML warrants further investigation. In this review, we correlate the potential links between macrophages, the development of therapy resistance, and patient outcomes in AML. We specifically focus on macrophage reprogramming by AML cells, macrophage-driven activation of anti-cell death pathways in AML cells, and the association between macrophage phenotypes and clinical outcomes in AML, including their potential prognostic value. Lastly, we discuss therapeutic targeting of macrophages, as a strategy to circumvent therapy resistance in AML, and discuss how emerging genomic and proteomic-based approaches can be utilised to address existing challenges in this research field.

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