Use of solid-phase microextraction for the analysis of bisphenol A and bisphenol A diglycidyl ether in food simulants

Abstract A method has been developed for determination of bisphenol A diglycidyl ether (BADGE) in 3 aqueous-based food simulants: water, 15% (v/v) ethanol, and 3% (w/v) acetic acid. BADGE is extracted with C18 cartridges and the extract Is concentrated under a stream of nitrogen. BADGE is quantltated by reversed-phase liquid chromatography with fluorescence detection. Relative precision at 200 μg/L was 3.4%, the detection limit of the method was 0.1 μg/L, and recoveries of spiking concentrations from 1 to 8 μg/L were nearly 100%. Relative standard deviations for the method ranged from 3.5 to 5.9%, depending on the identity of the spiked aqueousbased food simulant.

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Investigation of bisphenol a diglycidyl ether, bisphenol f diglycidyl ether and their hydroxy and chlorohydroxy derivatives stability in water-based food simulants

Czech Journal of Food Sciences ◽

10.17221/10679-cjfs ◽

2004 ◽

Vol 22 (SI - Chem. Reactions in Foods V) ◽

pp. S272-S275

Author(s):

I. Poustková ◽

J. Dobiáš ◽

J. Poustka ◽

M. Voldřich

Keyword(s):

Acetic Acid ◽

Bisphenol A ◽

Epoxy Resins ◽

High Performance ◽

Diglycidyl Ether ◽

Phase Gradient ◽

Bisphenol F ◽

Food Simulants ◽

Bisphenol A Diglycidyl Ether ◽

Food Simulant

Varnishes used as the inner coatings of food cans are often based on epoxy resins or vinylic organosols. The epoxy resins can be produced from bisphenol A (BPA) and bisphenol F (BPF) and they also contain bisphenol A diglycidyl ether (BADGE) of bisphenol F diglycidyl ether (BFDGE) as stabilising components. These compounds may break down during storage and also by influence of food simulants. The stability of BADGE and BFDGE was studied using reverse-phase gradient high performance liquid chromatography (RP-HPLC) with fluorescence detection (FLD). Four experiments were compared: (i) BPA solution at the concentration 3 μg/ml of each food simulant, (ii) BADGE solution at the concentration 3 μg/ml of each food simulant, (iii) BFDGE solution at the concentration 3 μg/ml of each food simulant and (iv) mixture of all bisphenols solution at the concentration 3 μg/ml of each food simulant. Distilled water, 10% ethanol, 95% ethanol and 3% acetic acid were used as food simulants. It was observed that BPA, BADGE and BFDGE were most stabile in 95% ethanol and least stabile in 3% acetic acid. Creation of hydroxy and chlorohydroxy derivatives was in each food simulant different so it cannot be predicted.

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Migration of Bisphenol A and Bisphenol A Diglycidyl-ether from Can Coatings into Food Simulants

Asian Journal of Chemistry ◽

10.14233/ajchem.2015.18790 ◽

2015 ◽

Vol 27 (8) ◽

pp. 3013-3018

Author(s):

Qin-Bao Lin ◽

Long-Fei Cai ◽

Shao-Jing Wu ◽

Zhi-Nan Chen ◽

Zhi-Wei Wang

Keyword(s):

Bisphenol A ◽

Diglycidyl Ether ◽

Food Simulants ◽

Bisphenol A Diglycidyl Ether

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Overall migration and specific migration of bisphenol A diglycidyl ether monomer andm‐xylylenediamine hardener from an optimized epoxy‐amine formulation into water‐based food simulants

Food Additives & Contaminants ◽

10.1080/02652039309374178 ◽

1993 ◽

Vol 10 (5) ◽

pp. 555-565 ◽

Cited By ~ 22

Author(s):

J. Simal Gándara ◽

P. López Mahía ◽

P. Paseiro Losada ◽

J. Simal Lozano ◽

S. Paz Abuín

Keyword(s):

Bisphenol A ◽

Diglycidyl Ether ◽

Food Simulants ◽

Epoxy Amine ◽

Bisphenol A Diglycidyl Ether ◽

Water Based

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Kinetics of the hydrolysis of bisphenol F diglycidyl ether in water-based food simulants. Comparison with bisphenol A diglycidyl ether

Journal of Agricultural and Food Chemistry ◽

10.1021/jf00017a034 ◽

1992 ◽

Vol 40 (5) ◽

pp. 868-872 ◽

Cited By ~ 21

Author(s):

P. Paseiro Losada ◽

J. Simal Lozano ◽

S. Paz Abuin ◽

P. Lopez Mahia ◽

J. Simal Gandara

Keyword(s):

Bisphenol A ◽

Diglycidyl Ether ◽

Bisphenol F ◽

Food Simulants ◽

Bisphenol A Diglycidyl Ether ◽

Water Based ◽

Kinetics Of ◽

Hydrolysis Of

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Stability of bisphenol A diglycidyl ether and bisphenol F diglycidyl ether in water-based food simulants

European Food Research and Technology ◽

10.1007/s00217-004-0995-1 ◽

2004 ◽

Vol 219 (5) ◽

pp. 534-539 ◽

Cited By ~ 16

Author(s):

Ivana Poustková ◽

Jaroslav Dobiáš ◽

Ingrid Steiner ◽

Jan Poustka ◽

Michal Voldřich

Keyword(s):

Bisphenol A ◽

Diglycidyl Ether ◽

Bisphenol F ◽

Food Simulants ◽

Bisphenol A Diglycidyl Ether ◽

Water Based

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Levels of Bisphenol A Diglycidyl Ether (BADGE) and Bisphenol F Diglycidyl Ether (BFDGE) in Canned Liquid Infant Formula Products in Canada and Dietary Intake Estimates

Journal of AOAC International ◽

10.1093/jaoac/92.6.1780 ◽

2009 ◽

Vol 92 (6) ◽

pp. 1780-1789 ◽

Cited By ~ 10

Author(s):

Xu-Liang Cao ◽

Guy Dufresne ◽

Genevieve Clement ◽

Stphane Blisle ◽

Andr Robichaud ◽

...

Keyword(s):

Body Weight ◽

Bisphenol A ◽

Infant Formula ◽

Solid Phase ◽

Diglycidyl Ether ◽

Bisphenol F ◽

Bisphenol A Diglycidyl Ether ◽

Daily Intakes ◽

Stable Forms

Abstract A method based on solid-phase extraction followed by HPLC analysis with fluorescence detection was developed for the determination of bisphenol A diglycidyl ether (BADGE) and bisphenol F diglycidyl ether (BFDGE) in liquid infant formula. In this method, instead of trying to isolate and measure each individual form of the molecules, hydrolysis of BADGE, BFDGE, BADGEH2O, and BFDGEH2O was forced to completion to their stable forms, BADGE2H2O and BFDGE2H2O, before extraction. The method LODs were 2.0 ng/g for BADGE and 3.0 ng/g for BFDGE. Extraction recoveries were 6191 for BADGE, and 5582 for BFDGE over the concentration range of 10 to 50 ng/g. The method was used to analyze samples of 21 canned liquid infant formula products for BADGE and BFDGE. BADGE was detected in samples of all products at levels ranging from as low as 2.4 ng/g to as high as 262 ng/g. BFDGE was detected in only one product (40 ng/g), and this product also had the highest BADGE level (262 ng/g). HPLC/MS/MS with a similar LOD was also used to confirm the results. The probable daily intakes (PDI) of BADGE and BFDGE due to consumption of canned liquid infant formula were estimated for infants from premature to 1218 months of age. The maximum PDI of BADGE was 22 g/kg body weight/day for the 1218 months old with the maximum formula intake. The maximum PDI of BFDGE was <3.4 g/kg body weight/day.

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