The Pros and Cons of Testosterone Replacement in Elderly Men: A Panel Discussion

2000 ◽  
Vol 75 (1) ◽  
pp. S88-S91 ◽  
Author(s):  
Annika Hinze ◽  
Jean Bacon ◽  
Alejandro Buchmann ◽  
Sharma Chakravarthy ◽  
Mani Chandi ◽  
...  

This chapter is a panel discussion in writing. The field of event-based systems finds researchers from a number of different backgrounds: distributed systems, streaming data, databases, middleware, and sensor networks. One of the consequences is that everyone comes to the field with a slightly different mindset and different expectations and goals. In this chapter, we try to capture some of the voices that are influential in our field. Seven panellists from academia and industry were invited to answer and discuss questions about event-based systems. The questions were distributed via email, to which each participant replied their initial set of answers. In a second round every panelist was given the opportunity to expand their statement and discuss the contributions of the other panellists. The questions asked can be grouped into two types. Questions in the first group refer to each participant’s understanding of the basic concepts of event-based systems (EBS), the pros and cons of EBS, typical assumptions of the field and how they understood EBS to fit into the overall landscape of software architectures. The second group of questions pointed to the future of EBS, possible killer applications and the challenges that EBS researchers in academia and industry need to address in the medium and long term. The next section gives each panellist’s initial statements as well as their comments to other participants’ contributions. Each participant’s section starts with a short introduction of the panellist and their work. In the final section, we compare and reflect on the statements and discussions that are presented by the seven panellists.


2009 ◽  
Vol 94 (9) ◽  
pp. 3414-3423 ◽  
Author(s):  
Christina Koutsari ◽  
Asem H. Ali ◽  
K. Sreekumaran Nair ◽  
Robert A. Rizza ◽  
Peter O'Brien ◽  
...  

Context: Aging, low dehydroepiandrosterone (DHEA), and testosterone are associated with increased adiposity and metabolic risk. Treatment with these hormones may improve these abnormalities. Objective: The objective of the study was to determine effects of aging, DHEA, or testosterone replacement on adiposity, meal fat partitioning, and postabsorptive lipolysis. Design: This was a cross-sectional, 2-yr, double-blind, randomized, placebo-controlled trial. Setting: The study was conducted in the general community. Patients: Elderly women and men (≥60 yr) with low DHEA sulfate (women and men) and bioavailable testosterone (men) concentrations and young adults. Interventions: Thirty elderly women each received 50 mg DHEA or placebo daily for 2 yr. Thirty elderly men received 75 mg DHEA, 29 received 5 mg testosterone (patch), and 32 received placebo daily for 2 yr. Thirty young women and 32 young men served as controls. Main Outcome Measures: In vivo measures of meal fat storage into sc fat, postabsorptive lipolysis, and regional adiposity at baseline and after treatment. Results: At baseline, the elderly had more body fat, greater systemic lipolysis (women, P = 0.0003; men, P < 0.0001) adjusted for resting energy expenditure, greater meal fat oxidation (women, P = 0.026; men, P = 0.0025), and less meal fat storage in sc fat (women, P = 0.0139; men, P= 0.0006). Although testosterone treatment increased meal fat storage into upper- vs. lower-body fat in elderly men, neither hormone affected regional adiposity, meal fat oxidation, or systemic lipolysis. Conclusions: Aging, in the context of low DHEA sulfate (women and men) and bioavailable testosterone (men) concentrations, is associated with changes in meal fat partitioning and postabsorptive lipolysis that are not corrected by DHEA and only partly corrected by testosterone replacement. DHEA or testosterone treatment of hormone-deficient elderly does not normalize adipose tissue lipolysis, but testosterone restores a “youthful” meal fat storage pattern in elderly men.


Radical Hope ◽  
2020 ◽  
pp. 191-200
Author(s):  
Michal Krumer-Nevo

The fourth chapter of Part Three brings to life the voices of activists, students, and social workers as they were heard in a panel discussion that took place at Ben-Gurion University of the Negev in 2015. The chapter is a transcription of the discussion, which reveals the participants’ personal experiences with active excercising of rights, their attitudes toward it, the characteristics needed for this kind of practice, and the pros and cons of it.


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