scholarly journals Fatty Acid Metabolism in the Elderly: Effects of Dehydroepiandrosterone and Testosterone Replacement in Hormonally Deficient Men and Women

2009 ◽  
Vol 94 (9) ◽  
pp. 3414-3423 ◽  
Author(s):  
Christina Koutsari ◽  
Asem H. Ali ◽  
K. Sreekumaran Nair ◽  
Robert A. Rizza ◽  
Peter O'Brien ◽  
...  
Keyword(s):  
Body Fat ◽  
Elderly Women ◽  
Fat Oxidation ◽  
The Elderly ◽  
Testosterone Replacement ◽  
Elderly Men ◽  
Fat Storage ◽  
Testosterone Treatment ◽  
Bioavailable Testosterone ◽  
Regional Adiposity

Context: Aging, low dehydroepiandrosterone (DHEA), and testosterone are associated with increased adiposity and metabolic risk. Treatment with these hormones may improve these abnormalities. Objective: The objective of the study was to determine effects of aging, DHEA, or testosterone replacement on adiposity, meal fat partitioning, and postabsorptive lipolysis. Design: This was a cross-sectional, 2-yr, double-blind, randomized, placebo-controlled trial. Setting: The study was conducted in the general community. Patients: Elderly women and men (≥60 yr) with low DHEA sulfate (women and men) and bioavailable testosterone (men) concentrations and young adults. Interventions: Thirty elderly women each received 50 mg DHEA or placebo daily for 2 yr. Thirty elderly men received 75 mg DHEA, 29 received 5 mg testosterone (patch), and 32 received placebo daily for 2 yr. Thirty young women and 32 young men served as controls. Main Outcome Measures: In vivo measures of meal fat storage into sc fat, postabsorptive lipolysis, and regional adiposity at baseline and after treatment. Results: At baseline, the elderly had more body fat, greater systemic lipolysis (women, P = 0.0003; men, P < 0.0001) adjusted for resting energy expenditure, greater meal fat oxidation (women, P = 0.026; men, P = 0.0025), and less meal fat storage in sc fat (women, P = 0.0139; men, P= 0.0006). Although testosterone treatment increased meal fat storage into upper- vs. lower-body fat in elderly men, neither hormone affected regional adiposity, meal fat oxidation, or systemic lipolysis. Conclusions: Aging, in the context of low DHEA sulfate (women and men) and bioavailable testosterone (men) concentrations, is associated with changes in meal fat partitioning and postabsorptive lipolysis that are not corrected by DHEA and only partly corrected by testosterone replacement. DHEA or testosterone treatment of hormone-deficient elderly does not normalize adipose tissue lipolysis, but testosterone restores a “youthful” meal fat storage pattern in elderly men.

scholarly journals LITERATURE REVIEW MANFAAT SENAM LANSIA TERHADAP KUALITAS HIDUP LANSIA

2020 ◽  
Vol 8 (2) ◽  
pp. 48-55
Author(s):  
Sri Puzzy Handayani ◽  
Rina Puspita Sari ◽  
Wibisono Wibisono
Keyword(s):  
Literature Review ◽  
Elderly Women ◽  
The Elderly ◽  
Environmental Benefits ◽  
Research Articles ◽  
Psychological Benefits ◽  
Elderly Men ◽  
Minimum Duration ◽  
Improve Sleep Quality

ABSTRACTIntroduction: 52.31% of the number of health complaints in elderly women is higher than the percentage of elderly men is 49, 74%. Changes that occur in the elderly tend to decrease in physical, psychological, psychosocial systems. This requires an action activity that can reach all aspects of the decline that is by doing elderly gymnastics. The purpose of this research to identify the benefits of elderly exercise on the quality of life of the elderly. Research methods by using literature review as a guide to search for research articles obtained from the internet using the Science Direct site, and Google Scholar. The results analysis of 10 selected research articles shows that elderly exercise can have several benefits, namely: physical benefits can improve physical fitness, body balance, breathing, and decreased blood pressure in elderly hypertension. Psychological benefits can improve sleep quality, decrease insomnia levels, decrease depression levels, reduce stress levels, and manage pain. Social and environmental benefits. Elderly exercise 3 times a week with a minimum duration of 30 minutes and a maximum of 40 minutes with a time of> 4 weeks will be more effective in getting many benefits.

scholarly journals Association between Socioeconomic Status, Physical Health and Need for Long-term Care among the Chinese Elderly

2019 ◽  
Vol 16 (12) ◽  
pp. 2124 ◽  
Author(s):  
Fanlei Kong ◽  
Lingzhong Xu ◽  
Mei Kong ◽  
Shixue Li ◽  
Chengchao Zhou ◽  
...  
Keyword(s):  
Socioeconomic Status ◽  
Physical Health ◽  
Long Term Care ◽  
Elderly Women ◽  
The Elderly ◽  
Elderly Men ◽  
Term Care ◽  
Chinese Elderly ◽  
Men And Women

The aim of this study was to explore the relationship between socioeconomic status (SES), physical health and the need for long-term care (NLTC) of the Chinese elderly, and further, to provide evidence-based advice for establishing an LTC system in China. A cross-sectional survey was conducted in Shandong Province, China in 2017 by using multi-stage random sampling method. Data were collected from elderly individuals aged 60 years and older by self-designed questionnaires through face-to face interviews. A total of 7070 participants were finally included in the database (40.3% male, 59.7% female). Chi-square test analysis and structural equation modeling (SEM) were conducted to clarify the association between SES, physical health and NLTC among the Chinese elderly men and women in Shandong Province. The results of the SEM analysis showed that physical health exerted a strong and negative effect on the NLTC for both genders, with a slightly stronger effect found among the elderly men. SES was found to be significantly and negatively related to the NLTC among the elderly women, while no statistical significance was found for the association between SES and NLTC for elderly men. A significant and positive association between SES and physical health was observed among the elderly men and women, with a slightly stronger effect among the elderly women. Implications for lowering the NLTC and developing an LTC system were addressed based on the findings above.

Prevalence of Mental Disorders in the Elderly in the Community of Madrid: Results of the Mentdis_ICF65+ Study

2017 ◽  
Vol 20 ◽  
Author(s):  
Berta Ausín ◽  
Manuel Muñoz ◽  
Ana Belén Santos-Olmo ◽  
Eloísa Pérez-Santos ◽  
Miguel A. Castellanos
Keyword(s):  
Mental Disorders ◽  
Mental Disorder ◽  
Elderly Women ◽  
The Elderly ◽  
Prevalence Rates ◽  
Elderly Men ◽  
Related Disorder ◽  
Significance Level ◽  
Relationship Of ◽  
The Relationship

AbstractThe MentDis_ICF65+ Project is an epidemiological study of mental disorders in people 65 to 85 years old in several European cities, including Madrid. Its aim is to determine the lifetime, 12-month, and 1-month prevalence of the main mental disorders in the elderly. The relationship of age and sex with each mental disorder was examined. The sample was collected through random sampling of people over 65 in Madrid, and consisted of 555 persons between 65 and 85 years old. The CIDI65+ was administered. Estimates of prevalence and odds ratios (OR) were made using sample frequencies and according to sex and age. Excluding nicotine dependence, 40.12% of the sample was found to have suffered a mental disorder at some time in their lives, 29.89% in the past year, and 17.70% were currently suffering from a mental disorder. The disorders with the highest prevalence rates were anxiety disorders, alcohol-related disorders, and mood disorders. Elderly women had a higher risk of suffering an anxiety disorder (OR men/women 0.42; CI 0.25–0.68) with a significance level of p < .001, while elderly men were more affected by any substance-related disorder (OR men/women 3.96; CI 1.62–11.07) with a significance level of p < .001. Each disorder’s prevalence decreased with age (OR 65–74/75–85, 1.85; CI 1.25–2.75) with a significance level of p < .01. Results show higher prevalence rates than previous studies reported. The main implications of this study, and the need to adapt mental health services for people over 65, are highlighted.

THE IMPACT OF CO-RESIDENT SPOUSES AND SONS ON ELDERLY MORTALITY IN RURAL BANGLADESH

2000 ◽  
Vol 32 (1) ◽  
pp. 89-98 ◽  
Author(s):  
M. OMAR RAHMAN
Keyword(s):  
Elderly Women ◽  
Economic Status ◽  
Elderly Person ◽  
The Elderly ◽  
Elderly Men ◽  
Old People ◽  
Prospective Data ◽  
Rural Bangladesh ◽  
Adult Sons ◽  
The Impact

This paper uses prospective data from the Matlab surveillance system in rural Bangladesh to demonstrate that initially co-resident spouses and sons have a major impact on the subsequent mortality of old people, with significant differences by the sex of the elderly person, and the age of the son. Spouses significantly reduce mortality by similar magnitudes for both elderly men and women. On the other hand, co-resident adult sons reduce mortality for elderly women much more than for elderly men, with younger sons being more beneficial than older sons. Furthermore, both married and unmarried females appear to benefit equally from co-resident adult sons. Finally, this analysis suggests that the impact of spouses and sons on mortality in old age is not substantially mediated through changes in elderly economic status.

High Body Mass Index (BMI) in North American Elderly Diffuse Large B-Cell Lymphoma (DLBCL) Patients Treated with Rituximab (R)-CHOP Compensates for Negative Impact of Male Gender

Blood ◽  
2014 ◽  
Vol 124 (21) ◽  
pp. 3046-3046
Author(s):  
Zheng Zhou ◽  
Alfred W. Rademaker ◽  
Leo I. Gordon ◽  
Ann S. LaCasce ◽  
Allison Crosby-Thompson ◽  
...  
Keyword(s):  
Clinical Outcomes ◽  
Elderly Women ◽  
Negative Impact ◽  
B Cell Lymphoma ◽  
Female Gender ◽  
The Elderly ◽  
Male Gender ◽  
Elderly Men ◽  
Free Survival ◽  
High Bmi

Abstract Background: Recent reports from prospective clinical trials of R-containing chemotherapy in DLBCL patients suggest that gender, weight and/or BMI influence clinical outcomes. Pharmacokinetic studies by the German High Grade Lymphoma Study Group have shown that R clearance is relatively slow in elderly women compared to men, leading to higher levels and prolonged exposure and hence better clinical outcomes in elderly females. Specifically, it has been suggested that elderly men are underdosed, based on faster R clearance (Muller et al., 2012; Pfreundschuh et al., 2014). Regarding BMI as a predictor of clinical outcome, analysis of the US Veterans Administrative database showed an association between increased BMI and improved survival in DLBCL patients (Carson et al., 2012), while the ECOG clinical trial (E4494) for elderly DLBCL patients failed to reveal a significant association of BMI with clinical outcomes, or a gender difference related to BMI in failure-free survival (Hong et al., 2014). To further investigate these associations, we studied the effect of gender, BMI as well as body surface area (BSA, the actual dosing parameter), and potential interactions among these factors on long-term clinical outcomes for elderly DLBCL patients in the National Comprehensive Cancer Network (NCCN) non-Hodgkin lymphoma database. Methods: De novo DLBCL patients with age > 60 yrs. were identified from the NCCN adult DLBCL cohort. Patients were diagnosed between June 2000 and December 2010. All received R as part of first-line therapy. Outcomes evaluated included progression free survival (PFS) and overall survival (OS) at 3 years based on patient gender, age and BMI/ BSA at presentation. Gender was stratified based on BMI (<=18.5, >18.5-25, >25) or BSA (<=2, >2), and Kaplan-Meier estimates were calculated. Associations with disease progression and survival were additionally adjusted for the International Prognostic Index (IPI) in the multivariable Cox regression analyses. Results: Of the 1,386 DLBCL patients who received R, 627 were elderly with age >60 yrs. The majority of elderly men were either overweight or large: only 13% had BMI <=25 and only 26% had BSA <=2. Elderly men (n=325, 52%) experienced worse PFS (3 yr-Hazard Ratio, HR 1.5, 95% CI: 1.1-2.1, p=0.02) and OS (3 yr-HR 1.6, 1.1-2.4, p=0.01) compared to elderly women. Of note, the poor risk associated with male gender was associated with patients over 60, but not the younger cohort (3 yr-PFS, HR 1.3, 0.9-1.9, p=0.12). The benefit associated with female gender in the elderly cohort decreased with increases in BMI and BSA (Figure). There was a benefit associated with female gender when compared to male gender in the BMI (<=25) (log rank, p<0.01) and BSA <=2 (p=0.04) strata, but not among patients with high BMI (>25) or BSA (>2). In multivariable analysis, low or normal BMI as compared to high BMI was independently associated with poor outcomes (3-yr PFS, HR: 1.6, 1.1-2.2, p<0.01) after adjusting for gender. There was a trend suggesting that BSA <=2 correlated with worse 3-yr PFS in the elderly group adjusting for gender (3 yr-HR 1.4, 0.9-2.0, p=0.12). The HR estimates remained largely unchanged after adjusting for IPI. Notably, higher BMI was not associated with more favorable prognostic clinical factors. Conclusions: Our results, derived from analysis of unselected patients with DLBCL treated with R-containing chemotherapy at major NCCN centers, confirmed an age-dependent disadvantage to male gender in treatment outcomes. The magnitude of this negative effect diminished with higher levels of BMI and BSA, with the greatest negative impact occurring in elderly men with BMI <=25 or BSA <=2. Our findings support efforts to optimize R dosing, especially in the elderly male subset with BMI <=25 or BSA <=2. Future prospective trials should factor size and gender into the study design and analysis. Our results support the ongoing German randomized trial to evaluate enhanced rituximab dosing for older male patients. Figure 1 Figure 1. Disclosures No relevant conflicts of interest to declare.

Exploratory Study toward Development of the French Version of the Questionnaire on Personality Traits (QPT/VKP–4) in an Elderly Population in Comparison to Young Adults

2014 ◽  
Vol 115 (1) ◽  
pp. 115-132 ◽  
Author(s):  
R. Courtois ◽  
O. Plaisant ◽  
I. J. Duijsens ◽  
A. Enfoux ◽  
N. Coutard ◽  
...  
Keyword(s):  
Young Adults ◽  
Personality Traits ◽  
Exploratory Study ◽  
Elderly Women ◽  
The Elderly ◽  
Elderly Men ◽  
Personality Dimension ◽  
Big 5 ◽  
French Version ◽  
Depressive Personality

This research is an exploratory study toward development of the French version of the Questionnaire on Personality Traits (QPT/VKP–4). The goal was to assess its association with the Big Five Inventory (BIG–5) and to explore the personality characteristics of the elderly compared to young adults. The 241 participants included 83 elderly people and 158 young adults. Borderline and anxious personality disorders were less frequent in elderly women than in young women, and depressive personality disorder was less frequent in elderly men. Dimension scores were higher for Conscientiousness in the elderly, Agreeableness in elderly women, and Extraversion in elderly men. Statistically significant correlations were found between personality dimension scores using the VKP–4 and the BIG–5.

scholarly journals Associação de polimorfismos genéticos com capacidades físicas e composição corporal em idosas

2016 ◽  
Vol 18 (1) ◽  
pp. 11
Author(s):  
Vitor Nolasco de Moraes ◽  
Gustavo Duarte Ferrari ◽  
Thiago Chiaratto ◽  
Letícia Perticarrara Ferezin ◽  
Átila Alexandre Trapé ◽  
...  
Keyword(s):  
Older Women ◽  
Cardiorespiratory Fitness ◽  
Body Fat ◽  
Elderly Women ◽  
The Elderly ◽  
The Body ◽  
Lower Limbs ◽  
Fat Percentage ◽  
Capacity Flexibility ◽  
Physical Capacities

DOI: http://dx.doi.org/10.5007/1980-0037.2016v18n1p11 The elderly population has grown substantially, and the decline in physical capacities and increase in the body fat percentage are important characteristics of aging. Genetic factors may explain these declines and studies related to this issue are justified because they predict what physical capacities present larger declines in different individuals and enable the adoption of strategies to slow them. Thus, the aim of this study was to evaluate the effect of ACE I / D and ACTN3 R / X genetic polymorphisms on body fat, muscle strength and power levels, aerobic capacity, flexibility and agility in older women. Sixty-six older women were genotyped with respect to ACTN3 and ACE polymorphisms for the division of groups and submitted to anthropometric measurements, physical tests in the AAHPERD and RIKLI and JONES test batteries and IPAQ to determine the level of physical activity and the Food Consumption Marker Form. Older women with XX genotype in relation to ACTN3 genotype had lower levels of flexibility of upper and lower limbs and lower cardiorespiratory fitness. Moreover, in relation to the ACE genotype, ID individuals exhibited higher cardiorespiratory fitness and lower body fat percentages. In relation to the other variables, there was no statistical difference among groups. It was concluded that the genetic variants under study play a role in some of the physical capacities and body composition in elderly women. In the future, data of this nature will enable each individual to have specific health interventions directed to the variables showing higher genetic potential for decline. 

scholarly journals Criterion validity of the Ekblom-Bak and the Åstrand submaximal test in an elderly population

2019 ◽  
Vol 120 (2) ◽  
pp. 307-316 ◽  
Author(s):  
Daniel Väisänen ◽  
Örjan Ekblom ◽  
Elin Ekblom-Bak ◽  
Eva Andersson ◽  
Jonna Nilsson ◽  
...  
Keyword(s):  
Indirect Calorimetry ◽  
Elderly Population ◽  
Elderly Women ◽  
The Elderly ◽  
Criterion Validity ◽  
Cycle Ergometer ◽  
Mean Difference ◽  
Elderly Men ◽  
The Mean

Abstract Purpose The aim of this study was to validate the submaximal Ekblom-Bak test (EB-test) and the Åstrand test (Å-test) for an elderly population. Methods Participants (n = 104), aged 65–75 years, completed a submaximal aerobic test on a cycle ergometer followed by an individually adjusted indirect calorimetry VO2max test on a treadmill. The HR from the submaximal test was used to estimate VO2max using both the EB-test and Å-test equations. Results The correlation between measured and estimated VO2max using the EB method and Å method in women was r = 0.64 and r = 0.58, respectively and in men r = 0.44 and r = 0.44, respectively. In women, the mean difference between estimated and measured VO2max was − 0.02 L min−1 (95% CI − 0.08 to 0.04) for the EB method and − 0.12 L min−1 (95% CI − 0.22 to − 0.02) for the Å method. Corresponding values for men were 0.05 L min−1 (95% CI − 0.04 to 0.14) and − 0.28 L min−1 (95% CI − 0.42 to − 0.14), respectively. However, the EB method was found to overestimate VO2max in men with low fitness and the Å method was found to underestimate VO2max in both women and men. For women, the coefficient of variance was 11.1%, when using the EB method and 19.8% when using the Å method. Corresponding values for men were 11.6% and 18.9%, respectively. Conclusion The submaximal EB-test is valid for estimating VO2max in elderly women, but not in all elderly men. The Å-test is not valid for estimating VO2max in the elderly.

Distribution of Haemoglobin in Patients Presenting to Their General Practitioner, and its Correlation with Serum Ferritin

1990 ◽  
Vol 27 (1) ◽  
pp. 15-20 ◽  
Author(s):  
G S Challand ◽  
Androulla Michaeloudis ◽  
Rodeina R Watfa ◽  
S J Coles ◽  
J L Macklin
Keyword(s):  
General Practitioner ◽  
Iron Deficiency ◽  
Serum Ferritin ◽  
Elderly Women ◽  
The Elderly ◽  
Bimodal Distribution ◽  
Elderly Men ◽  
Elderly Male ◽  
Female Patients ◽  
Child Bearing

We have conducted a survey in the United Kingdom in order to evaluate the prevalence of anaemia and of iron deficiency in elderly male and female patients and in female patients of child-bearing age presenting to their general practitioner. Although haemoglobin values were approximately normally distributed, there was evidence of a bimodal distribution of serum ferritin values, particularly in elderly men. A correlation between serum ferritin and haemoglobin values was found to exist, both in the elderly and in younger women. The overall prevalence of anaemia in the study population was 14·3%, although it was higher for elderly men (20·1%) than either elderly women (13·7%) or women of child-bearing age (11·9%). Iron deficiency associated with anaemia was more common in elderly men (45·2% of those anaemic) than elderly women (28·6%) or women of child-bearing age (25·6%). This survey indicates that the prevalence of anaemia among certain groups of high risk patients presenting for consultation to their general practitioner is about 1 in 7, although the prevalence is as high as 1 in 5 in elderly men.

Remarriage after Divorce

1987 ◽  
Vol 30 (2) ◽  
pp. 162-179 ◽  
Author(s):  
Paul C. Glick ◽  
Sung-Ling Lin
Keyword(s):  
Elderly Women ◽  
Divorce Rate ◽  
The Elderly ◽  
Living Alone ◽  
Elderly Men ◽  
First Marriage ◽  
General Decline ◽  
Graduate School Training ◽  
Remarriage Rate ◽  
School Training

Among adults who had ended their first marriage in divorce, about three-fourths of the elderly men and two-thirds of the elderly women in both 1970 and 1980 were found to be remarried. However, the general decline in remarriage at the younger ages during the 1970s was accentuated among those under 35 years old. Although the proportion remarried among women with graduate school training was the smallest, that proportion declined less during the 1970s than for women in any other educational level. In both 1970 and 1980, the proportion remarried was positively correlated with personal income for men but negatively for women. An estimated two-thirds of those who end their first marriage in divorce will eventually remarry while they have young children living with them. During the lifetime of women in their second marriage after their first marriage ended in divorce, only one-third of their children are born after remarriage, whereas two-thirds are born before their second marriages. During the 1970s, the proportion of currently divorced adults living alone or sharing the homes of relatives diminished, while the proportion living as cohabitants outside marriage rose substantially. It appears as if both the divorce rate and the remarriage rate are approaching a period of relative stability.

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