Indications for Neurosurgical Intervention in Metastatic Lesions of the Central Nervous System

1975 ◽  
Vol 59 (2) ◽  
pp. 487-494 ◽  
Author(s):  
Charles A. Fager
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Metastatic Lesions ◽  
The Central Nervous System ◽  
Neurosurgical Intervention

scholarly journals Is Crush Cytology of Central Nervous System Lesions Relevant in Surgical Practice Today?

2019 ◽  
Vol 10 (01) ◽  
pp. 34-38 ◽  
Author(s):  
Krishan Kumar Yadav ◽  
Rashmi Bhatti ◽  
Nikhil Moorchung ◽  
Deepti Mutreja ◽  
Ajay S. Carvalho
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Imaging Techniques ◽  
Diagnostic Technique ◽  
High Grade ◽  
Surgical Practice ◽  
The Central Nervous System ◽  
Cns Lesions ◽  
Neurosurgical Intervention

ABSTRACT Background: Intraoperative crush cytology is a useful tool for diagnosing the lesions of the central nervous system (CNS). However, because of the development of newer and better imaging techniques, it is important to evaluate if crush cytology is still relevant in neurosurgical practice. Aims: We evaluated the crush cytology smears in a series of cases where neurosurgical intervention was performed. We studied the role of crush cytology in the intraoperative diagnosis. We report a series of cases where intraoperative crush cytology helped the surgeon revise the surgery during the operation. Materials and Methods: A small portion of all CNS lesions was taken intraoperatively and the tissue was crushed between two slides. The slide was stained using the toluidine blue, Leishman stain, Pap stain and a routine H & E stain. The slides were the evaluated. Results: We evaluated the 50 cases of CNS lesions. We found that intraoperative crush cytology is particularly important in differentiating between neoplastic and nonneoplastic CNS lesions. It may also help in differentiating lymphomas from high-grade gliomas. Finally, crush cytology may help the surgeon in delineating the lesions during surgery. Conclusion: We conclude that crush cytology remains relevant in neurosurgical practice today and it should be adopted in all neurosurgical centers as a routine diagnostic technique.

scholarly journals Parkinsonism secondary to metastatic lesions within the central nervous system: a case report

2010 ◽  
Vol 4 (1) ◽  
Author(s):  
Eduardo Hortelano ◽  
Christian Perea ◽  
Esther Uña ◽  
Amelia Cebayos ◽  
Patricia Diezhandino ◽  
...  
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Case Report ◽  
System A ◽  
Metastatic Lesions ◽  
The Central Nervous System

Central brain herniation secondary to fulminant acute disseminated encephalomyelitis: implications for neurosurgical management

2006 ◽  
Vol 105 (3) ◽  
pp. 472-474 ◽  
Author(s):  
Raymond F. Sekula ◽  
Edward M. Marchan ◽  
Parviz Baghai ◽  
Peter J. Jannetta ◽  
Matthew R. Quigley
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Cerebral Edema ◽  
Acute Disseminated Encephalomyelitis ◽  
Small Subset ◽  
Brain Herniation ◽  
Demyelinating Disorder ◽  
Central Brain ◽  
The Central Nervous System ◽  
Neurosurgical Intervention

✓ Acute disseminated encephalomyelitis (ADEM), also known as postinfectious encephalomyelitis, is an immunologically mediated demyelinating disorder affecting the central nervous system that typically occurs after infection or vaccination. The prognosis of ADEM is generally favorable. In a small subset of patients with ADEM, however, fulminant cerebral edema requiring neurosurgical intervention will develop. Few recommendations are available to help the neurosurgeon in dealing with such cases. In this report, the authors present the case of a patient with ADEM in whom central brain herniation developed secondary to medically intractable cerebral edema. The authors review the salient features of the disease and suggest a role for neurosurgeons in cases of fulminant ADEM.

scholarly journals On improving medical care for patients with metastatic tumors of the central nervous system in the Republic of Tatarstan

2012 ◽  
Vol 93 (2) ◽  
pp. 241-245 ◽  
Author(s):  
V I Danilov ◽  
R Sh Khasanov ◽  
A G Alekseev ◽  
K T Shakirov ◽  
A A Nasher
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Medical Care ◽  
Metastatic Tumors ◽  
Significant Discrepancy ◽  
Metastatic Lesions ◽  
Number Of Patients ◽  
Study Results ◽  
The Central Nervous System ◽  
The Republic

Aim. To optimize medical care for patients with metastatic tumors of the central nervous system in the Republic of Tatarstan. Methods. The database of the Cancer Registry of the Republican Clinical Oncology Dispensary of the Ministry of Health Care of the Republic of Tatarstan and the case histories of patients treated in the neurosurgical departments for the period from 1998 to 2007 served as the material for this study. Results. Lung cancer, breast cancer, kidney cancer and melanoma were the most frequent types of cancers to metastasize to the central nervous system. There was a significant discrepancy between the predicted and the detected number of patients with metastatic lesions of the central nervous system. Studied was the quality of medical care provision to this category of patients. In the Republic of Tatarstan established is a modern instrumental base for the timely diagnosis of metastatic lesions of the central nervous system and their complex treatment in accordance with the current guidelines. However, the effectiveness of diagnostic and therapeutic measures still remains unsatisfactory. Conclusion. A set of measures for optimizing medical care for patients with metastatic tumors of the central nervous system has been developed in the Republic of Tatarstan.

Effects of Hyperoxia on Lung Utrastructure

1970 ◽  
Vol 28 ◽  
pp. 26-27
Author(s):  
Gladys Harrison
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Light Microscopy ◽  
Oxygen Effects ◽  
Age Dependent ◽  
The Central Nervous System ◽  
The Subject ◽  
Space Age ◽  
Alveolar Septa ◽  
Extensive Damage

With the advent of the space age and the need to determine the requirements for a space cabin atmosphere, oxygen effects came into increased importance, even though these effects have been the subject of continuous research for many years. In fact, Priestly initiated oxygen research when in 1775 he published his results of isolating oxygen and described the effects of breathing it on himself and two mice, the only creatures to have had the “privilege” of breathing this “pure air”.Early studies had demonstrated the central nervous system effects at pressures above one atmosphere. Light microscopy revealed extensive damage to the lungs at one atmosphere. These changes which included perivascular and peribronchial edema, focal hemorrhage, rupture of the alveolar septa, and widespread edema, resulted in death of the animal in less than one week. The severity of the symptoms differed between species and was age dependent, with young animals being more resistant.

Emigration of neutrophils in the central nervous system

1983 ◽  
Vol 41 ◽  
pp. 788-789
Author(s):  
John L.Beggs ◽  
John D. Waggener ◽  
Wanda Miller ◽  
Jane Watkins
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Osmium Tetroxide ◽  
White Blood Cells ◽  
Arterial Perfusion ◽  
E Coli ◽  
Intracisternal Injection ◽  
The Central Nervous System ◽  
Brain And Spinal Cord ◽  
Interendothelial Junctions

Studies using mesenteric and ear chamber preparations have shown that interendothelial junctions provide the route for neutrophil emigration during inflammation. The term emigration refers to the passage of white blood cells across the endothelium from the vascular lumen. Although the precise pathway of transendo- thelial emigration in the central nervous system (CNS) has not been resolved, the presence of different physiological and morphological (tight junctions) properties of CNS endothelium may dictate alternate emigration pathways.To study neutrophil emigration in the CNS, we induced meningitis in guinea pigs by intracisternal injection of E. coli bacteria.In this model, leptomeningeal inflammation is well developed by 3 hr. After 3 1/2 hr, animals were sacrificed by arterial perfusion with 3% phosphate buffered glutaraldehyde. Tissues from brain and spinal cord were post-fixed in 1% osmium tetroxide, dehydrated in alcohols and propylene oxide, and embedded in Epon. Thin serial sections were cut with diamond knives and examined in a Philips 300 electron microscope.

Mammalian Bone Marrow Acetylcholinesterase

1982 ◽  
Vol 40 ◽  
pp. 44-45
Author(s):  
Ezzatollah Keyhani
Keyword(s):  
Central Nervous System ◽  
Bone Marrow ◽  
Nervous System ◽  
Common Property ◽  
Extracellular Medium ◽  
The Central Nervous System ◽  
The Common ◽  
Mammalian Bone

Acetylcholinesterase (EC 3.1.1.7) (ACHE) has been localized at cholinergic junctions both in the central nervous system and at the periphery and it functions in neurotransmission. ACHE was also found in other tissues without involvement in neurotransmission, but exhibiting the common property of transporting water and ions. This communication describes intracellular ACHE in mammalian bone marrow and its secretion into the extracellular medium.

Glucuronyl 3-sulfate occurs exclusively on distal unmyelinated terminals of selected sensory neurons in the peripheral nervous system

1995 ◽  
Vol 53 ◽  
pp. 958-959
Author(s):  
S.S. Spicer ◽  
B.A. Schulte
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Cerebral Cortex ◽  
Peripheral Nervous System ◽  
Sensory Neurons ◽  
Sensory Nerves ◽  
Tissue Antigens ◽  
The Central Nervous System ◽  
The Brain ◽  
Leu 7

Generation of monoclonal antibodies (MAbs) against tissue antigens has yielded several (VC1.1, HNK- 1, L2, 4F4 and anti-leu 7) which recognize the unique sugar epitope, glucuronyl 3-sulfate (Glc A3- SO4). In the central nervous system, these MAbs have demonstrated Glc A3-SO4 at the surface of neurons in the cerebral cortex, the cerebellum, the retina and other widespread regions of the brain.Here we describe the distribution of Glc A3-SO4 in the peripheral nervous system as determined by immunostaining with a MAb (VC 1.1) developed against antigen in the cat visual cortex. Outside the central nervous system, immunoreactivity was observed only in peripheral terminals of selected sensory nerves conducting transduction signals for touch, hearing, balance and taste. On the glassy membrane of the sinus hair in murine nasal skin, just deep to the ringwurt, VC 1.1 delineated an intensely stained, plaque-like area (Fig. 1). This previously unrecognized structure of the nasal vibrissae presumably serves as a tactile end organ and to our knowledge is not demonstrable by means other than its selective immunopositivity with VC1.1 and its appearance as a densely fibrillar area in H&E stained sections.

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