Novel structures in galactoglucomannans of the lichens Cladonia substellata and Cladonia ibitipocae: significance as chemotypes

1999 ◽  
Vol 51 (3) ◽  
pp. 395-402 ◽  
Author(s):  
Sandra M Woranovicz ◽  
B.Mario Pinto ◽  
Philip A.J Gorin ◽  
Marcello Iacomini
Keyword(s):  
Planta Medica ◽  
2015 ◽  
Vol 81 (05) ◽  
Author(s):  
XH Cai ◽  
T Feng ◽  
XN Li ◽  
YP Liu ◽  
JH Shang ◽  
...  

2016 ◽  
Vol 1 (1) ◽  
Author(s):  
Brahma N. Singh ◽  
Garima Pandey ◽  
Prateeksha ◽  
J. Kumar

With the advent of green pharmaceuticals, the secondary metabolites derived from plants have provided numerous leads for the development of a wide range of therapeutic drugs; however the discovery of new drugs with novel structures has declined in the past few years. Cryptogams including lichens, bryophytes, and pteridophytes represent a group of small terrestrial plants that remain relatively untouched in the drug discovery process though some have been used as ethnomedicines by various tribes worldwide. Studies of their secondary metabolites are recent but reveal unique secondary metabolites which are not synthesized by higher plants. These compounds can have the potential to develop more potential herbal drugs for prevention and treatment of diseases The present article . deals with the secondary metabolites and pharmacological activities of cryptogams with an objective to bring them forth as potential source of biodynamic compounds of therapeutic value.


1997 ◽  
Vol 75 (5) ◽  
pp. 407-413 ◽  
Author(s):  
R D Mathison ◽  
T Malkinson ◽  
K E Cooper ◽  
J S Davison

2018 ◽  
Vol 19 ◽  
pp. 1-6 ◽  
Author(s):  
Dingjie Lu ◽  
Yang Fan Li ◽  
Hamed Seifi ◽  
Shiwei Zhou ◽  
Zi-Long Zhao ◽  
...  
Keyword(s):  

2011 ◽  
Vol 243-249 ◽  
pp. 1528-1535
Author(s):  
Yu Zhao ◽  
Yong Jun Zhou ◽  
Jing Sun ◽  
Jin Tao Tang ◽  
Xu Li

Cable-stayed self-anchored suspension composed bridges have novel structures and aesthetic appearance with complex system and difficulty for design and construction. In order to acquire a better knowledge of the load-carrying capability of this type of bridges, based on a real bridge and the theory of abnormal similarity, a full-bridge scaled down(1:20) test model was built to simulate the whole process of construction. The test results were preferably fit the theoretical calculation value. It can be seen that the design of the bridge was reasonable, and the accuracy of the calculation of finite element model was verified at the same time. The test and the related results can be used as the reference for the test and design of the similar bridges.


1990 ◽  
Vol 9 (1) ◽  
pp. 190-194 ◽  
Author(s):  
Hans H. Karsch ◽  
Karin Zellner ◽  
Patrizia Mikulcik ◽  
Joachim Lachmann ◽  
Gerhard Mueller
Keyword(s):  

CrystEngComm ◽  
2016 ◽  
Vol 18 (4) ◽  
pp. 566-579 ◽  
Author(s):  
Hai-Yang Guo ◽  
Zhi-Fang Li ◽  
Xiao Zhang ◽  
Li-Wei Fu ◽  
Yang-Yang Hu ◽  
...  

Seven compounds exhibiting novel structures constructed from arsenic–vanadium polyoxoanions and metal mixed-organic-ligand complexes have been synthesized and characterized.


2021 ◽  
Vol 17 ◽  
Author(s):  
Nafiseh Karimi ◽  
Rouhollah Vahabpour Roudsari ◽  
Zahra Hajimahdi ◽  
Afshin Zarghi

Background: Integrase enzyme is a validated drug target to discover novel structures as anti-HIV-1 agents. Objective: Novel series of thioimidazolyl diketo acid derivatives characterizing various substituents at N-1 and 2-thio positions of central ring were developed as HIV-1 integrase inhibitors. Results: The obtained molecules were evaluated in the enzyme assay, displaying promising integrase inhibitory activity with IC50 values ranging from 0.9 to 7.7 M. The synthesized compounds were also tested for antiviral activity and cytotoxicity using HeLa cells infected by the single-cycle replicable HIV-1 NL4-3. Conclusion: The most potent compound was 18i with EC50=19 µM, IC50 0.9 µM and SI= 10.5. Docking studies indicated that the binding mode of the active molecule is well aligned with the known HIV-1 integrase inhibitors.


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