Bioprospecting Cryptogams as Potential Source of Unique Biodynamic Phytochemicals with Diverse Pharmaceutical Applications

2016 ◽  
Vol 1 (1) ◽  
Author(s):  
Brahma N. Singh ◽  
Garima Pandey ◽  
Prateeksha ◽  
J. Kumar
Keyword(s):  
Secondary Metabolites ◽  
Higher Plants ◽  
New Drugs ◽  
Terrestrial Plants ◽  
Pharmacological Activities ◽  
Therapeutic Drugs ◽  
Potential Source ◽  
Therapeutic Value ◽  
Wide Range ◽  
Novel Structures

With the advent of green pharmaceuticals, the secondary metabolites derived from plants have provided numerous leads for the development of a wide range of therapeutic drugs; however the discovery of new drugs with novel structures has declined in the past few years. Cryptogams including lichens, bryophytes, and pteridophytes represent a group of small terrestrial plants that remain relatively untouched in the drug discovery process though some have been used as ethnomedicines by various tribes worldwide. Studies of their secondary metabolites are recent but reveal unique secondary metabolites which are not synthesized by higher plants. These compounds can have the potential to develop more potential herbal drugs for prevention and treatment of diseases The present article . deals with the secondary metabolites and pharmacological activities of cryptogams with an objective to bring them forth as potential source of biodynamic compounds of therapeutic value.

Bioprospecting Cryptogams as Potential Source of Unique Biodynamic Phytochemicals with Diverse Pharmaceutical Applications

2016 ◽  
Vol 1 (1) ◽  
Author(s):  
Brahma N. Singh ◽  
Garima Pandey ◽  
Prateeksha . ◽  
J. Kumar
Keyword(s):  
Secondary Metabolites ◽  
Higher Plants ◽  
New Drugs ◽  
Terrestrial Plants ◽  
Pharmacological Activities ◽  
Therapeutic Drugs ◽  
Potential Source ◽  
Therapeutic Value ◽  
Wide Range ◽  
Novel Structures

<p>With the advent of green pharmaceuticals, the secondary metabolites derived from plants have provided numerous leads for the<br />development of a wide range of therapeutic drugs; however the discovery of new drugs with novel structures has declined in the past few<br />years. Cryptogams including lichens, bryophytes, and pteridophytes represent a group of small terrestrial plants that remain relatively<br />untouched in the drug discovery process though some have been used as ethnomedicines by various tribes worldwide. Studies of their<br />secondary metabolites are recent but reveal unique secondary metabolites which are not synthesized by higher plants. These compounds<br />can have the potential to develop more potential herbal drugs for prevention and treatment of diseases The present article . deals with the<br />secondary metabolites and pharmacological activities of cryptogams with an objective to bring them forth as potential source of<br />biodynamic compounds of therapeutic value.</p><p> </p><p> </p><p><span>DOI: </span><a id="pub-id::doi" href="http://dx.doi.org/10.21756/cba.v1i1.10958">http://dx.doi.org/10.21756/cba.v1i1.10958</a></p>

scholarly journals Actinomycetes as An Environmental Scrubber

2021 ◽  
Author(s):  
Sutaria Devanshi ◽  
Kamlesh R. Shah ◽  
Sudipti Arora ◽  
Sonika Saxena
Keyword(s):  
Secondary Metabolites ◽  
Agricultural Waste ◽  
Chemical Compounds ◽  
Filamentous Bacteria ◽  
Primary And Secondary Metabolites ◽  
Sustainable Environment ◽  
Potential Source ◽  
Wide Range ◽  
Bioactive Secondary Metabolites ◽  
Broad Variety

Biotechnological tools engaged in the bioremediation process are in reality, sophisticated and dynamic in character. For specialized reasons, a broad variety of such devices are employed to produce a safe and balanced environment free of all types of toxins and so make life simpler for humans on planet Earth. Actinomycetes is one of these extremely important and functionally helpful groups. They can be used for a variety of bioremediation objectives, including biotransformation, biodegradation, and many more. Actinomycetes are one of the most varied groups of filamentous bacteria, capable of prospering in a variety of ecological settings because to their bioactive capabilities. They’re famous for their metabolic diversity, which includes the synthesis of commercially useful primary and secondary metabolites. They produce a range of enzymes capable of totally destroying all of the constituents. They are well-known for their ability to produce bioactive secondary metabolites. Members of various genera of Actinomycetes show promise for application in the bioconversion of underutilized urban and agricultural waste into high-value chemical compounds. The most potential source is a wide range of important enzymes, some of which are synthesized on an industrial scale, but there are many more that have yet to be discovered. Bioremediation methods, which use naturally existing microbes to clear residues and contaminated regions of dangerous organic chemicals, are improving all the time. In the realm of biotechnological science, the potential of actinomycetes for bioremediation and the synthesis of secondary metabolites has opened up intriguing prospects for a sustainable environment.

scholarly journals Antimicrobial Potential of Endophytes from Datura metel Linn.

2018 ◽  
Vol 8 (4) ◽  
pp. 27
Author(s):  
Madhu Priya M. ◽  
P. Agastian Simiyon Theoder
Keyword(s):  
Antimicrobial Activity ◽  
Disease Resistance ◽  
Secondary Metabolites ◽  
Endophytic Fungi ◽  
Higher Plants ◽  
Antimicrobial Potential ◽  
Therapeutic Drugs ◽  
Datura Metel ◽  
Novel Products ◽  
Ethyl Acetate Extracts

Endophytes are a suite of microorganisms that grow in the tissues of higher plants. Endophytes constitute a valuable source of secondary metabolites for the discovery of new potential therapeutic drugs.  Endophytes can have many effects on their host such as enhancement of stress, insect and disease resistance, and herbicide activities when in association with their host plant. The present study was to examine the antimicrobial activity of ethyl acetate extracts of endophytic fungi (both extra and intracellular) and actinomycete from the stem and root of Datura metel L. The crude extract of these endophytic isolates were screened for their antimicrobial potential. Among the endophytes, the extracellular fungal extract showed the highest antimicrobial activity when compared to intracellular fungi and actinomycetes. The studies and isolation of these compounds can be used as a good approach to search of novel products.

scholarly journals Natural Product Repertoire of the Genus Amphimedon

Marine Drugs ◽  
2018 ◽  
Vol 17 (1) ◽  
pp. 19 ◽  
Author(s):  
Nourhan Shady ◽  
Mostafa Fouad ◽  
Mohamed Salah Kamel ◽  
Tanja Schirmeister ◽  
Usama Abdelmohsen
Keyword(s):  
Secondary Metabolites ◽  
Natural Product ◽  
Bioactive Compounds ◽  
Biological Activities ◽  
Marine Sponges ◽  
Rich Source ◽  
Undescribed Species ◽  
Pharmacological Activities ◽  
Wide Range ◽  
Complete Survey

Marine sponges are a very attractive and rich source in the production of novel bioactive compounds. The sponges exhibit a wide range of pharmacological activities. The genus Amphimedon consists of various species, such as viridis, compressa, complanata, and terpenensis, along with a handful of undescribed species. The Amphimedon genus is a rich source of secondary metabolites containing diverse chemical classes, including alkaloids, ceramides, cerebrososides, and terpenes, with various valuable biological activities. This review covers the literature from January 1983 until January 2018 and provides a complete survey of all the compounds isolated from the genus Amphimedon and the associated microbiota, along with their corresponding biological activities, whenever applicable.

scholarly journals Sesquiterpene lactones – occurrence and biological properties. A review

2018 ◽  
Vol 73 (3) ◽  
pp. 83-95
Author(s):  
KATARZYNA OLESIŃSKA
Keyword(s):  
Biological Activity ◽  
Secondary Metabolites ◽  
Plant Pathogens ◽  
Higher Plants ◽  
Sesquiterpene Lactones ◽  
Biological Properties ◽  
Chemical Structures ◽  
Potential Source ◽  
Active Substances ◽  
Carbon Pathways

Sesquiterpene lactones are secondary metabolites commonly found in higher plants as well as mosses, lichens, and fungi. Currently, over 5000 of such compounds have been identified with a majority isolated from Asteraceae plants. They are characterised by different chemical structures associated with the presence of various carbon pathways and functional groups, which exert an impact on their pharmacological activity. These colourless substances are soluble in fats, alcohols, or water. They are often bitter ingredients regarded as bitter compounds. They are accumulated mainly in leaves, flower parts and seeds; less frequently, they are present in roots. Sesquiterpene lactones exhibit multidirectional biological activity: some of them have anticancer, anti-inflammatory, antidiabetic, analgesic, antiparasitic, antifungal, and bacteriostatic effects. Therefore, high hopes are placed on the medical and pharmaceutical use of these substances. Lactone compounds are also regarded as a potential source of new active substances used in agriculture to combat plant pathogens

scholarly journals Review POTENT PHARMACEUTICAL PRODUCTS FROM AQUATIC PLANTS – REVIEW

2021 ◽  
pp. 48-63
Author(s):  
MANJULA K SAXENA ◽  
NEERJA SINGH ◽  
SUDHIR KUMAR ◽  
DOBHAL MP ◽  
SOUMANA DATTA
Keyword(s):  
Secondary Metabolites ◽  
Aquatic Plants ◽  
Food Additives ◽  
Pharmaceutical Products ◽  
Biologically Active ◽  
New Drugs ◽  
Terrestrial Plants ◽  
Human Therapy ◽  
Unique Source ◽  
Coloring Agents

Several biologically active secondary metabolites from aquatic plants have been extracted and identified using modern instrumental BioTechniques and used in various ways as flavors, food, additives, coloring agents, nutraceuticals, cosmetics, and also as unique source of pharma industries for the discovery or development of new drugs. From algae to aquatic macrophytes belonging to various categories, aquatic plants produce a variety of compounds such as polyketides, peptides, alkaloids, flavonoids, phenolic compounds, terpenes, steroids, quinones, tannins, coumarins, and essential oils commercially involving in antibiotic, antiviral, antioxidant, antifouling, anti-inflammatory, anticancer, cytotoxic, and antimitotic activities; thus making them a rich source of medicinal compounds. Moreover, they are comprehensively used in human therapy, veterinary, agriculture, scientific research, and in countless areas. Importantly these chemicals are exercised for developing new antimicrobial and cancer drugs. Furthermore, antioxidant molecules in aquatic plants and seaweeds have recently been acknowledged. This review contains a consolidated contemporary document consisting of entire knowledge available on pharmaceutical products of aquatic plants and highlights major differences among secondary metabolites found in aquatic (algae) and terrestrial plants.

Synthesis and Antimicrobial Activity of Novel 1, 2, 4-Triazolopyrimidofuro- quinazolinones from Natural Furochromones (Visnagenone and Khellinone)

2020 ◽  
Vol 16 ◽  
Author(s):  
Ameen Ali Abu-Hashem ◽  
Hoda A. R. Hussein ◽  
Ahmed S. Aly
Keyword(s):  
2D Nmr ◽  
Antimicrobial Activities ◽  
New Drugs ◽  
Pharmacological Activities ◽  
Efficient System ◽  
Wide Range ◽  
Nmr Techniques ◽  
Analgesic Activities ◽  
New Compounds

Background: Previous and recent scientific research has shown that triazolopyrimidine and furochromones have a wide range of pharmacological activities in the treatment of numerous diseases, including anticancer, antiviral, anti-depressant, antimicrobial, anti-inflammatory, and analgesic activities. Objective: Preparation of new drugs used as antimicrobial activities derived from a natural furochromones as (1- hydrazinyl or methylthio),-furopyrimidoquinazolinone, 1, 2, 4-triazolopyrimidofuroquinazolin-5-one, and quinazolinepyrimidofuro- quinazoline-8, 10-dione and study of their biological activity as antimicrobial. Method: A series of novel N’-furopyrimidoquinazoline-hydrazide; 1, 2, 4-triazolopyrimidofuroquinazolin-5-one; furopyrimidoquinazolin-3-one and quinazoline-pyrimidofuroquinazoline-8, 10-dione derivatives were synthesized from substituted (methylthio)-furopyrimidoquinazolinone (3a-b) and 1-hydrazinyl-furopyrimidoquinazolinone (4a-b) as the starting material. Results: All compounds were synthesized in good yields (71-95%) in a gradually efficient system under the mild condition and some of the procedures were used a microwave oven. The new compounds have been confirmed by means of different spectroscopic ways such as IR, 1D and 2D -NMR techniques and mass spectrum. The in vitro to antimicrobial activities were evaluated for the prepared compounds using many types of bacteria (Gram positive and Gram negative) and fungi. Conclusion: 1, 2, 4-triazolopyrimidofuroquinazolin-5-one derivatives (10a-f, 8a-b, 7a-b and 6a-d) showed the most efficient antimicrobial activities compared with the cefotaxime sodium and nystatin as standard drugs.

scholarly journals Mulinane- and Azorellane-Type Diterpenoids: A Systematic Review of Their Biosynthesis, Chemistry, and Pharmacology

Biomolecules ◽  
2020 ◽  
Vol 10 (9) ◽  
pp. 1333 ◽  
Author(s):  
Angel de Jesús Dzul-Beh ◽  
Andrés Humberto Uc-Cachón ◽  
Jorge Bórquez ◽  
Luis A. Loyola ◽  
Luis Manuel Peña-Rodríguez ◽  
...  
Keyword(s):  
Systematic Review ◽  
Natural Products ◽  
Medicinal Plants ◽  
Secondary Metabolites ◽  
Biological Properties ◽  
Pharmacological Activities ◽  
Wide Range ◽  
Anti Inflammatory

Mulinane- and azorellane-type diterpenoids have unique tricyclic fused five-, six-, and seven-membered systems and a wide range of biological properties, including antimicrobial, antiprotozoal, spermicidal, gastroprotective, and anti-inflammatory, among others. These secondary metabolites are exclusive constituents of medicinal plants belonging to the Azorella, Laretia, and Mulinum genera. In the last 30 years, more than 95 mulinanes and azorellanes have been reported, 49 of them being natural products, 4 synthetics, and the rest semisynthetic and biotransformed derivatives. This systematic review highlights the biosynthetic origin, the chemistry, and the pharmacological activities of this remarkably interesting group of diterpenoids.

Bioactive Compounds and Distinctive Pharmacological Activity Guided Review of Aegle marmelos: A Miraculous Plant of Indigenous Medicine System

2020 ◽  
Vol 16 (7) ◽  
pp. 965-977
Author(s):  
Sourav Ghosh ◽  
Arvind Kumar ◽  
Neetu Sachan ◽  
Phool Chandra
Keyword(s):  
Bioactive Compounds ◽  
New Drugs ◽  
Therapeutic Effects ◽  
Human Beings ◽  
Indigenous Medicine ◽  
Aegle Marmelos ◽  
Pharmacological Activities ◽  
Wide Range ◽  
Ethnobotanical Uses ◽  
Different Parts

Background: It is always thought that traditional herbal drugs are safe, effective and economical and are used worldwide for healing purposes. Aegle marmelos, belonging to family Rutaceae, is an important medicinal plant of the indigenous medicine system in India. Despite the study on ethnobotanical uses and the presence of bioactive compounds, there was only a handful of research on A. marmelos. The therapeutic use of bioactive compounds is not explored properly. Objective: The objective of this study is to provide comprehensive data on the botanical description, ethnobotany, isolated bioactive compounds and their therapeutic effects according to the pharmacology of A. marmelos and its future prospects for further scientific investigation for the development of effective bioactive compounds. Methods: Literature searches were performed in various databases, such as PubMed, SciFinder and Google Scholar, for peer-reviewed research literature pertaining to the bioactive compounds present and distinctive pharmacological activities of A. marmelos. Results: The literature review indicates that different parts of A. marmelos possess various ethnobotanical uses. A large number of bioactive compounds isolated from different parts of the plant were reviewed which mainly belong to alkaloids, terpenoids, steroids, coumarins, flavonoids and carbohydrate in nature. The plant also possesses a wide range of pharmacological activities, such as antidiarrheal, antimicrobial, anticancer, hepatoprotective, antifertility, anti-inflammatory, wound healing, radioprotective, hypoglycemic and cardioprotective activity. Conclusion: It is clearly proven that different parts of A. marmelos possess numerous therapeutic effects for treating various ailments of human beings. As the scientists anticipated to develop new drugs from natural sources, investigation of modern drugs from A. marmelos should be emphasized. Still, extensive research studies are required on A. marmelos as it is the most important plant of the indigenous medicine system in India. Therefore, this review could be used as a good source of information for researchers who wish to proceed their exploration of A. marmelos.

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