Routes of Extraocular Extension of Uveal Melanoma: Risk Factors and Influence on Survival Probability

Uveal melanoma (UM) is currently classified by the World Health Organisation as a melanoma caused by risk factors other than cumulative solar damage. However, factors relating to ultraviolet radiation (UVR) susceptibility such as light-coloured skin and eyes, propensity to burn, and proximity to the equator, frequently correlate with higher risk of UM. These risk factors echo those of the far more common cutaneous melanoma (CM), which is widely accepted to be caused by excessive UVR exposure, suggesting a role of UVR in the development and progression of a proportion of UM. Indeed, this could mean that countries, such as Australia, with high UVR exposure and the highest incidences of CM would represent a similarly high incidence of UM if UVR exposure is truly involved. Most cases of UM lack the typical genetic mutations that are related to UVR damage, although recent evidence in a small minority of cases has shown otherwise. This review therefore reassesses statistical, environmental, anatomical, and physiological evidence for and against the role of UVR in the aetiology of UM.

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Assessment of Malignant Melanoma Risk Factors and Their Attitudes Towards Protection from the Sun in Patients Applying to Family Physician Polyclinics

Konuralp Tıp Dergisi ◽

10.18521/ktd.298063 ◽

2017 ◽

pp. 1-6

Author(s):

Ezgi Ağadayı ◽

Aybüke Demir Alsancak ◽

Duygu Üstünol ◽

İrfan Şencan ◽

Hatice Küçükceran ◽

...

Keyword(s):

Risk Factors ◽

Malignant Melanoma ◽

Family Physician ◽

The Sun ◽

Melanoma Risk

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Second Primary Melanoma: Risk Factors, Histopathologic Features, Survival, and Implications for Follow-Up

The American Surgeon ◽

10.1177/000313481608201034 ◽

2016 ◽

Vol 82 (10) ◽

pp. 1009-1013 ◽

Cited By ~ 8

Author(s):

Maris S. Jones ◽

Hitoe Torisu-Itakura ◽

Devin C. Flaherty ◽

Hans F. Schoellhammer ◽

Jihey Lee ◽

...

Keyword(s):

Risk Factors ◽

High Risk ◽

Cutaneous Melanoma ◽

Primary Melanoma ◽

Second Primary ◽

Melanoma Risk ◽

Impact On Survival ◽

The Impact ◽

Histopathologic Features

The impact on survival of a second primary melanoma (SPM) is unclear. We used our melanoma center's database to examine clinicopathologic risk factors and outcomes of stage 0 to IV cutaneous melanoma in patients with one versus two primaries. Among 12,325 patients with primary melanoma, 969 (7.86%) developed SPM. SPMs were significantly thinner than autologous primary melanomas ( P = 0.01), and 451 SPM patients had better overall and melanoma-specific survival than 451 prognostically matched non-SPM patients ( P < 0.0001 and 0.0001, respectively) at a median follow-up of 142.37 months. Patients with cutaneous melanoma are at high risk for development of SPM, but the development of SPM does not seem to impair survival.

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Local Failure After Episcleral Brachytherapy for Posterior Uveal Melanoma: Patterns, Risk Factors, and Management

American Journal of Ophthalmology ◽

10.1016/j.ajo.2017.05.028 ◽

2017 ◽

Vol 181 ◽

pp. 178-179

Author(s):

Paul T. Finger ◽

Wolfgang A.G. Sauerwein

Keyword(s):

Risk Factors ◽

Uveal Melanoma ◽

Local Failure

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Nonsteroidal Anti-Inflammatory Drugs and Risk of Melanoma

Journal of Skin Cancer ◽

10.1155/2011/598571 ◽

2011 ◽

Vol 2011 ◽

pp. 1-4 ◽

Cited By ~ 11

Author(s):

Joanne M. Jeter ◽

Joseph D. Bonner ◽

Timothy M. Johnson ◽

Stephen B. Gruber

Keyword(s):

Risk Factors ◽

Meta Analysis ◽

Structured Interview ◽

Melanoma Risk ◽

Unadjusted Odds Ratio ◽

Epidemiologic Evidence ◽

Inflammatory Drugs ◽

Chemopreventive Effect ◽

Anti Inflammatory

Because nonsteroidal anti-inflammatory drugs (NSAIDs) inhibit tumor growthin vitro, we investigated the association between NSAIDs and melanoma to determine if there was epidemiologic evidence of a chemopreventive effect from these medications. Three hundred twenty-seven subjects with incident melanoma and 119 melanoma-free controls completed a structured interview assessing melanoma risk factors. The unadjusted odds ratio (OR) for use of nonaspirin NSAIDs was 0.58 (95% CI 0.31–1.11), in a comparison of subjects with melanoma to controls. After adjustment for melanoma risk factors, the OR was 0.71 (95% CI 0.23–2.02). Aspirin users had an unadjusted OR of 0.85 (95% CI 0.45–1.69) and an adjusted OR of 1.45 (95% CI 0.44–4.74). In this pilot study, we found no evidence of a significant association between analgesic use and melanoma risk when potential confounders are assessed. Based on conflicting reports in the literature, meta-analysis may be appropriate.

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